Abstract:
:Liver dysfunction in hyperthyroid patients has not been well characterized. We analyzed the clinical records of 43 patients with hyperthyroidism to define the spectrum of clinical and liver test abnormalities. The patients were divided into three categories: (a) 18 patients with uncomplicated hyperthyroidism (HT) (b) 19 with hyperthyroidism and congestive heart failure (HT/CHF), and (c) 6 with hyperthyroidism and concomitant unrelated liver disease (HT/ULD). Hepatomegaly and/or spenomegaly were noted in 15 of 19 (79%) patients with HT/CHF as compared to 6 of 18 (33%) patients with HT and 3 of 6 (50%) patients with HT/ULD. Four patients with HT/CHF had ascites. Serum aminotransferase levels greater than 250 IU/L were noted in only 1 of 37 (3%) patients without unrelated liver disease. Patients with HT/ULD or HT/CHF had markedly low prothrombin time. Serum bilirubin levels as high as 323 microM were noted in patients with HT. No characteristic liver histology due to hyperthyroidism was noted. Severe liver test abnormalities, including deep jaundice and prolonged prothrombin time, can occur in patients with hyperthyroidism alone or with HT/CHF. This makes the diagnosis of concomitant, unrelated liver disease difficult until the hyperthyroidism has been controlled.
journal_name
J Clin Gastroenteroljournal_title
Journal of clinical gastroenterologyauthors
Fong TL,McHutchison JG,Reynolds TBdoi
10.1097/00004836-199204000-00010subject
Has Abstractpub_date
1992-04-01 00:00:00pages
240-4issue
3eissn
0192-0790issn
1539-2031journal_volume
14pub_type
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
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doi:10.1097/00004836-199506002-00003
更新日期:1995-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198906000-00021
更新日期:1989-06-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-198310000-00013
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journal_title:Journal of clinical gastroenterology
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更新日期:1987-02-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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更新日期:1985-12-01 00:00:00
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journal_title:Journal of clinical gastroenterology
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
doi:10.1097/MCG.0000000000000276
更新日期:2015-03-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199201000-00015
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199801000-00009
更新日期:1998-01-01 00:00:00
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章
doi:10.1097/00004836-199301000-00008
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,多中心研究
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journal_title:Journal of clinical gastroenterology
pub_type: 杂志文章,评审
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