Hypoxic hepatitis caused by severe hypoxemia from obstructive sleep apnea.

Abstract:

:Cardiac and circulatory failure are the main causes of hypoxic hepatitis. In a prospective study of 142 cases of hypoxic hepatitis collected during a 10-year period, we encountered two cases resulting from extreme arterial hypoxemia without congestive heart failure, cor pulmonale, or circulatory failure. Both patients were morbidly obese women admitted to the intensive care unit for carbonarcosis. Oxygen arterial saturation was very low, less than 35% in both patients, but there was no history of cardiac or respiratory failure and no clinical evidence of circulatory failure. Cardiac function, evaluated by isotopic scintigraphy, was normal. After the episode of hypoxic hepatitis, a diagnosis of obstructive sleep apnea was made clinically and confirmed by performing nocturnal oximetry, which showed multiple episodes of oxygen desaturation in both patients. Polysonography could be performed in one case and was typical of obstructive sleep apnea. Liver ischemia is the main mechanism leading to hypoxic hepatitis. More recently, the role of passive congestion of the liver has been emphasized. Arterial hypoxemia, however, is generally considered to be a minor factor. Our two cases support the hypothesis that severe arterial hypoxemia may lead to hypoxic hepatitis even in the absence of cardiac and circulatory failure.

journal_name

J Clin Gastroenterol

authors

Henrion J,Colin L,Schapira M,Heller FR

doi

10.1097/00004836-199706000-00013

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

245-9

issue

4

eissn

0192-0790

issn

1539-2031

journal_volume

24

pub_type

杂志文章
  • Epidemiology and Diagnosis of Gastroparesis in the United States: A Population-based Study.

    abstract:GOALS:We aimed to establish the epidemiological characteristics and documentation of diagnostic workup for gastroparesis (GP). BACKGROUND:No study has used a national database to evaluate the prevalence, demographics, and associated comorbid conditions of GP, and document rates of proper diagnosis. MATERIALS AND METH...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001231

    authors: Syed AR,Wolfe MM,Calles-Escandon J

    更新日期:2020-01-01 00:00:00

  • Effect of Consent and Educational Adjuncts to Consent on Patient Perceptions About Colonoscopy.

    abstract:BACKGROUND AND AIMS:Informed consent is a vital preprocedural step for endoscopy but there are substantial variations in its delivery. We therefore sought to assess a multifaceted intervention to improve the consent process. METHODS:Gastroenterologists at a tertiary center were educated on the recommended components o...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000001093

    authors: Fudman DI,Papamichael K,Roemi L,Rao V,Falchuk KR,Leffler DA,Feuerstein JD

    更新日期:2019-09-01 00:00:00

  • Colonic variceal hemorrhage: diagnosis and management.

    abstract::Lower gastrointestinal bleeding colonic varices is infrequent. We report a patient in whom the diagnosis was made by angiography and in whom portosystemic shunt has been helpful. We believe that the treatment of choice for colonic varices is portosystemic shunt, as attempts at resection, judged by the reports in the l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198502000-00011

    authors: Katz LB,Shakeed A,Messer J

    更新日期:1985-02-01 00:00:00

  • Hereditary pancreatitis in a Chinese family.

    abstract::In a Chinese family with hereditary pancreatitis, two members are proven to have chronic pancreatitis. The propositus, a 31-year-old man, had epigastric pain since the age of 18. Multiple calcifications in the region of the pancreas were seen on plain film of the abdomen, ultrasonography, computed tomography, and endo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199002000-00021

    authors: Lin JT,Wang TH,Chen DS

    更新日期:1990-02-01 00:00:00

  • Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the united states: a population-based study.

    abstract:BACKGROUND:Intrahepatic cholangiocarcinoma (ICC) is a highly fatal disease with limited therapeutic options. The determinants, trends, and outcomes of different therapies for ICC are largely unknown in the United States. METHODS:Using data from the Surveillance, Epidemiology, and End-Results-(SEER) Medicare database, ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e31802f3132

    authors: Shaib YH,Davila JA,Henderson L,McGlynn KA,El-Serag HB

    更新日期:2007-11-01 00:00:00

  • Nephrolithiasis and intestinal disease.

    abstract::Kidney stones in patients with inflammatory bowel disease are usually composed of calcium oxalate. Two factors are important in the increased absorption of dietary oxalate which is responsible for those stones: 1) increased absorption of oxalate in the presence of steatorrhea, and 2) increased permeability of the colo...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198502000-00002

    authors: Dobbins JW

    更新日期:1985-02-01 00:00:00

  • Appendectomy and tonsillectomy in patients with inflammatory bowel disease.

    abstract::Recent reports of reduced appendectomy rates in patients with ulcerative colitis have not distinguished between primary appendectomy (surgery for appendicitis) and incidental appendectomy (removal of the appendix for other reasons). In the present case control study, we examined the frequency of primary appendectomy i...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199512000-00006

    authors: Smithson JE,Radford-Smith G,Jewell GP

    更新日期:1995-12-01 00:00:00

  • The pathogenesis of hemorrhoids and their treatment by anorectal bandotomy.

    abstract::The role of the anorectal band in the genesis of hemorrhoids is studied. The anorectal band is a fibroepithelial tube which is a remnant of the anorectal sinus. Seventy-six hemorrhoid patients and 32 controls were studied. Rectal neck pressure recording was done for all subjects. Two biopsies were taken from the lower...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198404000-00006

    authors: Shafik A

    更新日期:1984-04-01 00:00:00

  • GERD evaluation: time for a new paradigm?

    abstract::In the past there has been reliance on heartburn and acid regurgitation as the cardinal symptoms of gastro-esophageal reflux. Now it is recognized that diverse additional symptoms including extraesophageal manifestations are essential components of gastroesophageal reflux disease (GERD). Furthermore, previous reliance...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/01.mcg.0000225693.69745.49

    authors: Modlin IM,Malfertheiner P,Hunt RH,Armstrong D,Holtmann G,Quigley EM,Spechler SJ

    更新日期:2007-03-01 00:00:00

  • Colonoscopy after Golytely preparation in acute rectal bleeding.

    abstract::Thirty-five consecutive patients with acute hematochezia, negative gastric aspirates, and negative sigmoidoscopy underwent urgent colonoscopy after Golytely purgation. Mucosal visualization was excellent. Colonic bleeding lesions were identified in 24 of 35 patients, and hemorrhage originating proximal to the ileoceal...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198602000-00010

    authors: Caos A,Benner KG,Manier J,McCarthy DM,Blessing LD,Katon RM,Gogel HK

    更新日期:1986-02-01 00:00:00

  • Safety of Propofol Used as a Rescue Agent During Colonoscopy.

    abstract:GOAL:The goal of this study was to evaluate the safety of propofol when used by gastroenterologists in patients who have an inadequate response to standard sedation (narcotics and benzodiazepines). BACKGROUND:Many patients fail to achieve adequate sedation from narcotics and benzodiazepines during colonoscopy. The adm...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000445

    authors: Okeke FC,Shaw S,Hunt KK,Korsten MA,Rosman AS

    更新日期:2016-09-01 00:00:00

  • Relation among plasma ghrelin level, gastric emptying, and psychologic condition in patients with functional dyspepsia.

    abstract:BACKGROUND AND GOALS:Neurohormonal factors might play a role in the pathogenesis of functional dyspepsia (FD). However, the role of ghrelin, a gastrointestinal hormone that stimulates gastric motility, in FD is not yet clearly defined. The present study was designed to investigate plasma ghrelin levels and their relati...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000225614.94470.47

    authors: Takamori K,Mizuta Y,Takeshima F,Akazawa Y,Isomoto H,Ohnita K,Ohba K,Omagari K,Shikuwa S,Kohno S

    更新日期:2007-05-01 00:00:00

  • Role of Interventional Radiology in Complications of Portal Hypertension.

    abstract::Portal hypertension, a consequence of end-stage liver disease and liver cirrhosis can lead to significant morbidity and mortality for patients through abnormal fluid accumulation as well as the formation of portosystemic shunts and varices. Treatment of the sequelae of portal hypertension can be achieved through endov...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0000000000001180

    authors: Shreve L,Lee EW

    更新日期:2019-05-01 00:00:00

  • Bleeding Meckel's diverticulum in an adult.

    abstract::The 99mtechnetium pertechnetate nuclear red blood cell scan proved to be a valuable diagnostic tool in localizing the site of bleeding, from a Meckel's diverticulum, in a 41-year-old man. When peptic ulcer or colorectal disease has been excluded by panendoscopy, bleeding Meckel's diverticulum remains a diagnostic cons...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198904000-00019

    authors: Farr CM,Iqbal R,Bezmalinovic Z,Gladen HE,Stern R

    更新日期:1989-04-01 00:00:00

  • Barrett's esophagus complicating achalasia after esophagomyotomy. A clinical, radiologic, and pathologic study of 70 patients with achalasia and related motor disorders.

    abstract::Of 70 patients with achalasia and related motor disorders, 3 developed Barrett's esophagus 5, 8, and 15 years after esophagomyotomy. One of the three had dysplastic changes in the Barrett's mucosa. Although an increased incidence of gastroesophageal reflux, esophagitis, and stricture are well-known complications after...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Agha FP,Keren DF

    更新日期:1987-04-01 00:00:00

  • The cost of knowing the truth-limitations to a cost-benefit analysis of upper GI endoscopy.

    abstract::In a prospective series of 284 upper gastrointestinal (GI) endoscopies, outcome was evaluated by a cost-benefit analysis. Two-thirds of the endoscopies had a negative result, or a diagnosis was found which was not worth the costs of the endoscopy. The overall diagnostic gain of 284 endoscopies, however, outweighed the...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198204000-00003

    authors: Sonnenberg A,Blum AL

    更新日期:1982-04-01 00:00:00

  • Higher incidence of diabetes in liver transplant recipients with hepatitis C.

    abstract::We assessed the clinical and biochemical parameters associated with the development of posttransplantation diabetes (PTDM) in 52 liver transplant recipients followed up for 1 year. Diabetes was present before transplantation in 9.6% (5 of 52) of patients, and PTDM occurred in 23% (11 of 47) of the remaining liver tran...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-199801000-00009

    authors: Knobler H,Stagnaro-Green A,Wallenstein S,Schwartz M,Roman SH

    更新日期:1998-01-01 00:00:00

  • Of mice and men: lessons on Crohn's disease and the spirit of scientific inquiry.

    abstract::Over the past 10 years, Kiron Das and his associates have developed an animal model for the study of a putative Crohn's disease (CD)-specific antigen. Athymic T-cell deficient nu/nu mice inoculated with intestinal and lymph node tissue filtrates from patients with CD sometimes develop lymphomas and/or lymph node plasm...

    journal_title:Journal of clinical gastroenterology

    pub_type: 评论,杂志文章

    doi:

    authors: Sachar DB

    更新日期:1989-12-01 00:00:00

  • Determination of thiopurine methyltransferase genotype or phenotype optimizes initial dosing of azathioprine for the treatment of Crohn's disease.

    abstract:BACKGROUND:although azathioprine (AZA) is an effective immunomodulator in treating Crohn's disease, some patients develop leukopenia and risk severe infections. Thiopurine methyltransferase (TPMT) is an enzyme responsible for the metabolism of AZA, and its activity is inversely related to the risk of developing acute l...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200209000-00008

    authors: Regueiro M,Mardini H

    更新日期:2002-09-01 00:00:00

  • Cognitive-behavioral intervention for irritable bowel syndrome.

    abstract::A 41-year-old white man with a 2-year history of irritable bowel syndrome (IBS) was referred for psychological treatment. At the time of assessment he was being treated with Metamucil and Darvocet N-100s with little success. A detailed psychosocial assessment indicated several areas for cognitive-behavioral interventi...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198704000-00020

    authors: Litt MD,Baker LH

    更新日期:1987-04-01 00:00:00

  • Clinical features of patients with negative results from traditional diagnostic work-up and Crohn's disease findings from capsule endoscopy.

    abstract:INTRODUCTION:Capsule endoscopy (CE) can detect Crohn's disease in patients with suggestive symptoms but with negative results from the traditional diagnostic work-up (ileocolonoscopy and small bowel follow-through). The objective of this study was to determine which clinical features predict the diagnosis of Crohn's di...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-200609000-00006

    authors: Valle J,Alcántara M,Pérez-Grueso MJ,Navajas J,Muñoz-Rosas C,Legaz ML,Cuena R,Carrobles JM

    更新日期:2006-09-01 00:00:00

  • Histologic Tumor Grade and Preoperative Bilary Drainage are the Unique Independent Prognostic Factors of Survival in Pancreatic Ductal Adenocarcinoma Patients After Pancreaticoduodenectomy.

    abstract:BACKGROUND AND AIM:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer; most patients die during the first 6 months after diagnosis. With a 5% 5-year survival rate, is the fourth leading cause of cancer death in developed countries. In this regard, several clinical, histopathologic and bio...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0000000000000793

    authors: Macías N,Sayagués JM,Esteban C,Iglesias M,González LM,Quiñones-Sampedro J,Gutiérrez ML,Corchete LA,Abad MM,Bengoechea O,Muñoz-Bellvis L

    更新日期:2018-02-01 00:00:00

  • Chronic Pneumocystis carinii infection of the liver. A case report and review of the literature.

    abstract::Pneumocystis carinii infection of the liver is being reported with increasing frequency in patients with acquired immune deficiency syndrome (AIDS). The clinical picture typically resembles hepatitis. We report such an occurrence in a patient with persistent elevation of alkaline phosphatase and gamma-glutamyl transpe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/00004836-199207000-00013

    authors: Merkel IS,Good CB,Nalesnik M,Roseman SR

    更新日期:1992-07-01 00:00:00

  • The risk of bleeding after percutaneous liver biopsy: relation to platelet count.

    abstract::We sought to define the risk of bleeding after percutaneous aspiration liver biopsy in patients with low platelet counts but otherwise normal clotting factors. Eighty-seven patients underwent liver biopsy using the Menghini 1-second technique with either a 1.6-mm or a 1.2-mm needle. Bleeding occurred in three out of 1...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/00004836-198210000-00011

    authors: Sharma P,McDonald GB,Banaji M

    更新日期:1982-10-01 00:00:00

  • A comprehensive review of eosinophilic esophagitis in adults.

    abstract::Eosinophilic esophagitis is a recently described disease characterized by the presence of upper gastrointestinal tract symptoms in association with a dense esophageal eosinophilic infiltrate. The awareness and interest of physicians and researchers in this disease has been increasing as reflected by the number of publ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1097/MCG.0b013e318211f95b

    authors: Almansa C,Devault KR,Achem SR

    更新日期:2011-09-01 00:00:00

  • Psychosocial factors are the most common contraindications for antiviral therapy at initial evaluation in veterans with chronic hepatitis C.

    abstract:GOALS:To understand the degree to which psychosocial factors were preventing veterans with chronic hepatitis C virus from being eligible for antiviral treatment. BACKGROUND:Nearly 2% of the US population is infected with hepatitis C. Antiviral treatment requires substantial adherence despite challenging side effects. ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/01.mcg.0000123203.36471.70

    authors: Rowan PJ,Tabasi S,Abdul-Latif M,Kunik ME,El-Serag HB

    更新日期:2004-07-01 00:00:00

  • Serous cystadenoma in communication with the pancreatic duct: an unusual radiologic and pathologic entity.

    abstract::Cross-sectional imaging is frequently used in the diagnosis of pancreatic cysts, but there can be overlap in radiographic appearance. We present a case of a patient with presumed intraductal papillary mucinous neoplasm (IPMN) who was ultimately found to have a serous cystadenoma in communication with the pancreatic du...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181d3458d

    authors: Berman L,Mitchell KA,Israel G,Salem RR

    更新日期:2010-07-01 00:00:00

  • The interleukin-8-251 A allele is associated with increased risk of noncardia gastric adenocarcinoma in Helicobacter pylori-infected Koreans.

    abstract:BACKGROUND AND GOALS:Chronic inflammation associated with Helicobacter pylori infection is a risk factor of gastric adenocarcinoma. Interleukin-8 (IL-8) plays an important role in gastric mucosal inflammation induced by H. pylori infection. Recently, studies on the association of genetic polymorphisms of various proinf...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章

    doi:10.1097/MCG.0b013e3181646701

    authors: Ye BD,Kim SG,Park JH,Kim JS,Jung HC,Song IS

    更新日期:2009-03-01 00:00:00

  • Effects of microencapsulated vs. enteric-coated acetylsalicylic acid on gastric and duodenal mucosa: an endoscopic study.

    abstract::Two preparations of acetylsalicylic acid (ASA) were tested for their effects on gastroduodenal mucosa in a randomized crossover double-blind study that involved 12 healthy volunteers. Medication M (Monobeltin) consisted of 1,050 mg ASA provided with an enteric coat and medication C (Colfarit) consisted of 1,000 mg of ...

    journal_title:Journal of clinical gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004836-198806000-00008

    authors: Malfertheiner P,Stanescu A,Rogatti W,Ditschuneit H

    更新日期:1988-06-01 00:00:00

  • Isolated gastric sarcoidosis. Unique remnant of disseminated disease.

    abstract::Isolated granulomatous disease was identified in a gastrectomy specimen after a gastrointestinal hemorrhage in a 61-year-old white woman. She died postoperatively. No other areas of granulomatous tissue were identified at autopsy. Ten years previously, pulmonary sarcoidosis was proven on lung biopsy. Conceivable, othe...

    journal_title:Journal of clinical gastroenterology

    pub_type: 杂志文章,评审

    doi:

    authors: Panella VS,Katz S,Kahn E,Ulberg R

    更新日期:1988-06-01 00:00:00