Abstract：
:Psoriasis is a common skin disease with a genetic background and significant human leukocyte antigen (HLA) associations. HLA-Cw6 is the most frequently described association, particularly with psoriasis of the early onset type. Few studies of its correlation with various psoriasis clinical phenotypes and severity of the disease have been published so far; none in the Polish population. In this study 78 patients with psoriasis vulgaris were evaluated clinically and subdivided according to the age of onset and the type of psoriasis. A system of disease severity evaluation was applied to each patient. All patients and the control group (70 unrelated persons) were typed for HLA-Cw*06. The results show that Cw*06 allele frequency was higher in psoriatics than in the control group. Our investigation confirms that the Cw*06 allele is positively associated with psoriasis vulgaris of the early onset type, with a positive family history and its more severe form.
journal_name
J Appl Genetjournal_title
Journal of applied geneticsauthors
Szczerkowska-Dobosz A,Rebała K,Szczerkowska Z,Witkowska-Toboła Asubject
Has Abstractpub_date
2004-01-01 00:00:00pages
473-6issue
4eissn
1234-1983issn
2190-3883pii
238journal_volume
45pub_type
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