Current genetic methodologies in the identification of disaster victims and in forensic analysis.

Abstract:

:This review presents the basic problems and currently available molecular techniques used for genetic profiling in disaster victim identification (DVI). The environmental conditions of a mass disaster often result in severe fragmentation, decomposition and intermixing of the remains of victims. In such cases, traditional identification based on the anthropological and physical characteristics of the victims is frequently inconclusive. This is the reason why DNA profiling became the gold standard for victim identification in mass-casualty incidents (MCIs) or any forensic cases where human remains are highly fragmented and/or degraded beyond recognition. The review provides general information about the sources of genetic material for DNA profiling, the genetic markers routinely used during genetic profiling (STR markers, mtDNA and single-nucleotide polymorphisms [SNP]) and the basic statistical approaches used in DNA-based disaster victim identification. Automated technological platforms that allow the simultaneous analysis of a multitude of genetic markers used in genetic identification (oligonucleotide microarray techniques and next-generation sequencing) are also presented. Forensic and population databases containing information on human variability, routinely used for statistical analyses, are discussed. The final part of this review is focused on recent developments, which offer particularly promising tools for forensic applications (mRNA analysis, transcriptome variation in individuals/populations and genetic profiling of specific cells separated from mixtures).

journal_name

J Appl Genet

authors

Ziętkiewicz E,Witt M,Daca P,Zebracka-Gala J,Goniewicz M,Jarząb B,Witt M

doi

10.1007/s13353-011-0068-7

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

41-60

issue

1

eissn

1234-1983

issn

2190-3883

journal_volume

53

pub_type

杂志文章,评审
  • The glyceraldehyde-3-phosphate dehydrogenase promoter of the food yeast Candida utilis strain NRRL Y-660 is functional in Agrobacterium tumefaciens.

    abstract::The glyceraldehyde-3-phosphate dehydrogenase promoter of the food yeast Candida utilis strain NRRL Y-660 was cloned to create a novel integrative vector for Agrobacterium tumefaciens-mediated transformation. The new binary vector harbors β-glucuronidase activity as reporter and kanamicin/geneticin resistance as select...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-013-0162-0

    authors: González T,Eng F,Fraga R,Fonseca J,Amores I

    更新日期:2013-11-01 00:00:00

  • The MMP2 gene may be associated with longissimus dorsi muscle area in the pig (Sus scrofa).

    abstract::The matrix metalloproteinase-2 gene (MMP2) was found to be associated with hip structure in pigs. Recently three quantitative trait loci (QTLs) for loin muscle area were found on chromosome 6, to which MMP2 was mapped. In the present study, association analyses were conducted in two pig populations for a single-nucleo...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195679

    authors: Onteru SK,Fan B,Rothschild MF

    更新日期:2009-01-01 00:00:00

  • A doubled haploid rye linkage map with a QTL affecting α-amylase activity.

    abstract::A rye doubled haploid (DH) mapping population (Amilo × Voima) segregating for pre-harvest sprouting (PHS) was generated through anther culture of F(1) plants. A linkage map was constructed using DHs, to our knowledge, for the first time in rye. The map was composed of 289 loci: amplified fragment length polymorphism (...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-011-0029-1

    authors: Tenhola-Roininen T,Kalendar R,Schulman AH,Tanhuanpää P

    更新日期:2011-08-01 00:00:00

  • Development of an efficient retrotransposon-based fingerprinting method for rapid pea variety identification.

    abstract::Fast and efficient DNA fingerprinting of crop cultivars and individuals is frequently used in both theoretical population genetics and in practical breeding. Numerous DNA marker technologies exist and the ratio of speed, cost and accuracy are of importance. Therefore even in species where highly accurate and polymorph...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03194627

    authors: Smýkal P

    更新日期:2006-01-01 00:00:00

  • Interval mapping of QTLs controlling yield-related traits and seed protein content in Pisum sativum.

    abstract::A linkage map of garden pea was constructed on the basis of 114 plants (F2 generation) derived from a cross combination Wt10245 x Wt11238. The map, consisting of 204 morphological, isozyme, AFLP, ISSR, STS, CAPS and RAPD markers, was used for interval mapping of quantitative trait loci (QTLs) controlling seed number, ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Irzykowska L,Wolko B

    更新日期:2004-01-01 00:00:00

  • Testing the utility of site-specific recombinases for manipulations of genome of moenomycin producer Streptomyces ghanaensis ATCC14672.

    abstract::Streptomyces ghanaensis ATCC14672 is the producer of phosphoglycolipid antibiotics moenomycins that for almost 40 years were used worldwide as an animal feed additive. As the use of moenomycins narrows down (due to bans in the EU and some other countries), it opens the opportunity to develop much-needed antibiotics ag...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-015-0283-8

    authors: Lopatniuk M,Ostash B,Makitrynskyy R,Walker S,Luzhetskyy A,Fedorenko V

    更新日期:2015-11-01 00:00:00

  • Expression of Npc1 in glial cells corrects sterility in Npc1(-/-) mice.

    abstract::Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selectiv...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195698

    authors: Donohue C,Marion S,Erickson RP

    更新日期:2009-01-01 00:00:00

  • Morphological diversity of androgenic carrot plants.

    abstract::The aim of this study was to evaluate phenotypic variation of R0 androgenic plants obtained from four seed sources and donor plants by anther culture. Several morphological traits (leaf size, petiole length, leaf division, cortex colour) and the range of diversity were evaluated. There was large variation in all trait...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Kozik EU,Nowak R,Kłosińska U,Górecka K,Krzyzanowska D,Górecki R

    更新日期:2002-01-01 00:00:00

  • First results on the genetic diversity of the invasive signal crayfish Pacifastacus leniusculus (Dana, 1852) in Europe using novel microsatellite loci.

    abstract::The introduction of non-native crayfish in aquatic ecosystems is very common due to human activities (e.g. aquaculture, recreational and commercial fisheries). The signal crayfish, Pacifastacus leniusculus (Dana, 1852), is one of the most widespread invasive species in Europe. Although several important ecological and...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-015-0272-y

    authors: Froufe E,Varandas S,Teixeira A,Sousa R,Filipová L,Petrusek A,Edsman L,Lopes-Lima M

    更新日期:2015-08-01 00:00:00

  • Genetic variability of milk fatty acids.

    abstract::The milk fatty acid (FA) profile is far from the optimal fat composition in regards to human health. The natural sources of variation, such as feeding or genetics, could be used to increase the concentrations of unsaturated fatty acids. The impact of feeding is well described. However, genetic effects on the milk FA c...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195649

    authors: Arnould VM,Soyeurt H

    更新日期:2009-01-01 00:00:00

  • Inheritance of seed dormancy in Tibetan semi-wild wheat accession Q1028.

    abstract::Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) is one of the Chinese endemic hexaploid wheat genetic resources, distributed only in the Qinghai-Xizang Plateau of China. It has special characters, such as a hulled glume and spike disarticulation. However, seed dormancy, another important character for ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Lan XJ,Wei YM,Liu DC,Yan ZH,Zheng YL

    更新日期:2005-01-01 00:00:00

  • Phenotype comparison confirms ZMYND11 as a critical gene for 10p15.3 microdeletion syndrome.

    abstract::Proper epigenetic regulation processes are crucial in the normal development of the human brain. An ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes. Some of these syndromes have overlapping clinical phenotypes due to ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-017-0408-3

    authors: Tumiene B,Čiuladaitė Ž,Preikšaitienė E,Mameniškienė R,Utkus A,Kučinskas V

    更新日期:2017-11-01 00:00:00

  • Marker-assisted selection of diploid and tetraploid potatoes carrying Rpi-phu1, a major gene for resistance to Phytophthora infestans.

    abstract::The Rpi-phu1 gene originates from an interspecific hybrid between Solanum stenotomum and S. phureja, and confers a high level of resistance to Phytophthora infestans (late blight) in potato. The Rpi-phu1 was introduced by crossing at the diploid level into the S. tuberosum gene pool and then transferred to the tetrapl...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195721

    authors: Sliwka J,Jakuczun H,Kamiński P,Zimnoch-Guzowska E

    更新日期:2010-01-01 00:00:00

  • A new SNP in the promoter region of the porcine MYF5 gene has no effect on its transcript level in m. longissimus dorsi.

    abstract::Myogenic factor 5 (myf-5) is the product of the MYF5 gene, belonging to the MyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene: A65C, C580T and C613T. The aim of this study was to evaluate the influence of the A65C transver...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03194600

    authors: Urbański P,Flisikowski K,Starzyński RR,Kurył J,Kamyczek M

    更新日期:2006-01-01 00:00:00

  • A simplified AFLP method for fingerprinting of common wheat (Triticum aestivum L.) cultivars.

    abstract::The simplified AFLP method was developed and evaluated for identification and genetic diversity studies of wheat cultivars. Selective primers exploited in AFLP assay based on a single cutting enzyme PstI ((PstI)AFLP) generated total of 111 robust fragments, including 67 (60%) monomorphic and 12 (11%) cultivar-specific...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Tyrka M

    更新日期:2002-01-01 00:00:00

  • Spectrum of NIPBL gene mutations in Polish patients with Cornelia de Lange syndrome.

    abstract::Cornelia de Lange syndrome (CdLS) is a rare multi-system genetic disorder characterised by growth and developmental delay, distinctive facial dysmorphism, limb malformations and multiple organ defects. The disease is caused by mutations in genes responsible for the formation and regulation of cohesin complex. About ha...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-012-0126-9

    authors: Kuzniacka A,Wierzba J,Ratajska M,Lipska BS,Koczkowska M,Malinowska M,Limon J

    更新日期:2013-02-01 00:00:00

  • The genetic diversity of group-1 homoeologs and characterization of novel LMW-GS genes from Chinese Xinjiang winter wheat landraces (Triticum aestivum L.).

    abstract::Group-1 homoelog genes in wheat genomes encode storage proteins and are the major determinants of wheat product properties. Consequently, understanding the genetic diversity of group-1 homoelogs and genes encoding storage proteins, especially the low-molecular-weight glutenins (LMW-GSs), within wheat landrace genomes ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-020-00564-6

    authors: Hu X,Dai S,Yan Y,Liu Y,Zhang J,Lu Z,Wei Y,Zheng Y,Cong H,Yan Z

    更新日期:2020-09-01 00:00:00

  • Neural stem cell implantation extends life in Niemann-Pick C1 mice.

    abstract::In order to evaluate the phenotypic effects of implanted neural stem cells (NSCs) in the mouse model of Niemann-Pick C (NPC) disease, we injected a well-characterized clone of murine NSCs into the cerebella of neonatal Npc1(-/-) and control mice. The implanted cells survived and were abundant in some regions of the ce...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195222

    authors: Ahmad I,Hunter RE,Flax JD,Snyder EY,Erickson RP

    更新日期:2007-01-01 00:00:00

  • Post mortem identification of deoxyguanosine kinase (DGUOK) gene mutations combined with impaired glucose homeostasis and iron overload features in four infants with severe progressive liver failure.

    abstract::Deoxyguanosine kinase deficiency (dGK) is a frequent cause of the hepatocerebral form of mitochondrial depletion syndrome (MDS). A group of 28 infants with severe progressive liver failure of unknown cause was recruited for post mortem search for deoxyguanosine kinase (DGUOK) gene mutations. Four affected patients (14...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-010-0008-y

    authors: Pronicka E,Węglewska-Jurkiewicz A,Taybert J,Pronicki M,Szymańska-Dębińska T,Karkucińska-Więckowska A,Jakóbkiewicz-Banecka J,Kowalski P,Piekutowska-Abramczuk D,Pajdowska M,Socha P,Sykut-Cegielska J,Węgrzyn G

    更新日期:2011-02-01 00:00:00

  • Decreased neural stem cell proliferation and olfaction in mouse models of Niemann-Pick C1 disease and the response to hydroxypropyl-β-cyclodextrin.

    abstract::The Npc1nih/nih-null model and the Npc1nmf164/nmf164 hypomorph models of Niemann-Pick C1 (NPC1) disease show defects in olfaction. We have tested the effects of the life-prolonging treatment hydroxypropyl-beta-cyclodextrin (HPBCD) on olfaction and neural stem cell numbers when delivered either systemically or by nasal...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-019-00517-8

    authors: Dragotto J,Palladino G,Canterini S,Caporali P,Patil R,Fiorenza MT,Erickson RP

    更新日期:2019-11-01 00:00:00

  • Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer.

    abstract::The ErbB signalling network plays a crucial role in the growth and progression of several cancers, including colorectal cancer (CRC), and includes potentially drug-targetable genes. Oncogenic activation of the ErbB pathway by mutations and focal amplifications have emerged recently as an important predictive marker of...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-014-0253-6

    authors: Szmida E,Karpiński P,Leszczynski P,Sedziak T,Kielan W,Ostasiewicz P,Sasiadek MM

    更新日期:2015-05-01 00:00:00

  • Genetic structure and phylogenetic relationships of the Polish Heavy horse.

    abstract::In this study a wide range of genetic markers (12 microsatellites, 7 blood-group loci, 10 blood-protein loci) and mitochondrial DNA (mtDNA) were used to assess genetic diversity in Polish Heavy horses. Three random samples were sequenced for 421 bp of the mitochondrial D-loop region, but no clear phylogenetic patterns...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03194645

    authors: Iwańczyk E,Juras R,Cholewiński G,Cothran EG

    更新日期:2006-01-01 00:00:00

  • Biallelic mutations in CYP24A1 or SLC34A1 as a cause of infantile idiopathic hypercalcemia (IIH) with vitamin D hypersensitivity: molecular study of 11 historical IIH cases.

    abstract::Idiopathic infantile hypercalcemia (IIH) is a mineral metabolism disorder characterized by severe hypercalcemia, failure to thrive, vomiting, dehydration, and nephrocalcinosis. The periodical increase in incidence of IIH, which occurred in the twentieth century in the United Kingdom, Poland, and West Germany, turned o...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-017-0397-2

    authors: Pronicka E,Ciara E,Halat P,Janiec A,Wójcik M,Rowińska E,Rokicki D,Płudowski P,Wojciechowska E,Wierzbicka A,Książyk JB,Jacoszek A,Konrad M,Schlingmann KP,Litwin M

    更新日期:2017-08-01 00:00:00

  • Founder event and its effect on genetic variation in translocated populations of noble crayfish (Astacus astacus).

    abstract::Establishing translocated populations is a common process to preserve and maintain genetic diversity of threatened species. In 2001, three translocated populations of noble crayfish (Astacus astacus) were established in the Czech Republic, founded by either adult or juvenile individuals from three particular source po...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-015-0296-3

    authors: Bláha M,Žurovcová M,Kouba A,Policar T,Kozák P

    更新日期:2016-02-01 00:00:00

  • Molecular identification of slow rusting resistance Lr46/Yr29 gene locus in selected triticale (× Triticosecale Wittmack) cultivars.

    abstract::Recently, leaf rust and yellow rust caused by the fungi Puccinia triticina Erikss. and P. striiformis Westend f. sp. tritici Eriks and Henn are diseases of increasing threat in triticale (× Triticosecale Wittmack, AABBRR, 2n = 6x = 42) growing areas. The use of genetic resistance is considered the most economical, eff...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-020-00562-8

    authors: Skowrońska R,Tomkowiak A,Nawracała J,Kwiatek MT

    更新日期:2020-09-01 00:00:00

  • A review of asthma genetics: gene expression studies and recent candidates.

    abstract::Recent evidence indicates an important role of inflammation pathways, airways remodeling and epithelium activation in asthma genetics. In particular, transcriptome studies have detected differentially expressed genes involved in eosinophil apoptosis, the arginase pathway, response to allergens or interleukins, and to ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章,评审

    doi:

    authors: Malerba G,Pignatti PF

    更新日期:2005-01-01 00:00:00

  • Cytological investigations of the interspecific hybrids of Nicotiana tabacum L. x N. glauca Grah.

    abstract::Interspecific amphihaploid and amphidiploid hybrids between Nicotiana glauca Grah. (2n = 24) and N. tabacum L. (2n = 48) cultivars BY 103 and K 326 were analysed. F1 amphihaploids (2n = 36) were viable and completely self- and cross-sterile, and mostly univalents were present during meiosis (with pairing range from 0 ...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:

    authors: Trojak-Goluch A,Berbeć A

    更新日期:2003-01-01 00:00:00

  • De novo transcriptome of the whole-body of the gastropod mollusk Philomycus bilineatus, a pest with medical potential in China.

    abstract::Philomycus bilineatus is a highly common gastropod mollusk pest in China and is also utilized to treat infectious diseases. However, no genomic resources are available for this non-model species. In the present study, the transcriptomic analysis of P. bilineatus was completed. After sequencing using the next generatio...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-020-00566-4

    authors: Li Z,Yuan Y,Meng M,Hu P,Wang Y

    更新日期:2020-09-01 00:00:00

  • Homozygous 2p11.2 deletion supports the implication of ELMOD3 in hearing loss and reveals the potential association of CAPG with ASD/ID etiology.

    abstract::Autism spectrum disorder (ASD) is a set of neurodevelopmental conditions characterized by early-onset difficulties in social communication and unusually restricted, repetitive behavior and interests. Parental consanguinity may lead to higher risk of ASD and to more severe clinical presentations in the offspring. Studi...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/s13353-018-0472-3

    authors: Lahbib S,Leblond CS,Hamza M,Regnault B,Lemée L,Mathieu A,Jaouadi H,Mkaouar R,Youssef-Turki IB,Belhadj A,Kraoua I,Bourgeron T,Abdelhak S

    更新日期:2019-02-01 00:00:00

  • Association of 3 polymorphisms in porcine troponin I genes (TNNI1 and TNNI2) with meat quality traits.

    abstract::The contractile protein troponin I (TnI), a constituent protein of the troponin complex located on the thin filaments of striated muscle, is involved in inhibition of calcium-induced myosin ATPase activity (and thus contraction). TnI-slow (slow-twitch skeletal muscle isoform, named TNNI1) and TnI-fast (fast-twitch ske...

    journal_title:Journal of applied genetics

    pub_type: 杂志文章

    doi:10.1007/BF03195710

    authors: Yang H,Xu ZY,Lei MG,Li FE,Deng CY,Xiong YZ,Zuo B

    更新日期:2010-01-01 00:00:00