Abstract：
:Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based on their mechanism of action among antimutagens, several classes of compounds may be distinguished. These are compounds with antioxidant activity; compounds that inhibit the activation of mutagens; blocking agents; as well as compounds characterized with several modes of action. It was reported previously that several antitumor compounds act through the antimutagenic mechanism. Hence, searching for antimutagenic compounds represents a rapidly expanding field of cancer research. It may be observed that, in recent years, many publications were focused on the screening of both natural and synthetic compounds for their beneficial muta/antimutagenicity profile. Thus, the present review attempts to give a brief outline on substances presenting antimutagenic potency and their possible mechanism of action. Additionally, in the present paper, a screening strategy for mutagenicity testing was presented and the characteristics of the most widely used antimutagenicity assays were described.
journal_name
J Appl Genetjournal_title
Journal of applied geneticsauthors
Słoczyńska K,Powroźnik B,Pękala E,Waszkielewicz AMdoi
10.1007/s13353-014-0198-9subject
Has Abstractpub_date
2014-05-01 00:00:00pages
273-85issue
2eissn
1234-1983issn
2190-3883journal_volume
55pub_type
杂志文章,评审abstract：:Proper epigenetic regulation processes are crucial in the normal development of the human brain. An ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes. Some of these syndromes have overlapping clinical phenotypes due to ...
journal_title：Journal of applied genetics
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更新日期：2011-02-01 00:00:00
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journal_title：Journal of applied genetics
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更新日期：2017-11-01 00:00:00
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更新日期：2015-05-01 00:00:00
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journal_title：Journal of applied genetics
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Journal of applied genetics
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更新日期：2001-01-01 00:00:00
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更新日期：2005-01-01 00:00:00
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journal_title：Journal of applied genetics
pub_type： 杂志文章
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更新日期：2009-01-01 00:00:00
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