Genotoxicity of inhalation anaesthetics: DNA lesions generated by sevoflurane in vitro and in vivo.

Abstract:

:A moderate genotoxic activity of halothane and isoflurane applied as volatile anaesthetics has already been shown. The aim of this work was to estimate a potential genotoxicity of sevoflurane, introduced to clinical practice later than halothane and isoflurane. A genotoxic activity of all three compounds was estimated by using the comet assay in human peripheral blood lymphocytes (PBL) proliferating in vitro. We demonstrated that in contrast to the previously studied anaesthetics, sevoflurane did not induce any increase in DNA migration in the studied conditions. To estimate a genotoxic effect of a prolonged exposure to halogenated anaesthetics in vivo, PBL taken from operating room personnel (n = 29) were tested for DNA degradation and compared with those from a control non-exposed group (n = 20). No significant differences were detected between the groups. We conclude that sevoflurane does not have genotoxic properties, both in vitro and in vivo.

journal_name

J Appl Genet

authors

Szyfter K,Szulc R,Mikstacki A,Stachecki I,Rydzanicz M,Jałoszyński P

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

369-74

issue

3

eissn

1234-1983

issn

2190-3883

pii

221

journal_volume

45

pub_type

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