Abstract:
:A moderate genotoxic activity of halothane and isoflurane applied as volatile anaesthetics has already been shown. The aim of this work was to estimate a potential genotoxicity of sevoflurane, introduced to clinical practice later than halothane and isoflurane. A genotoxic activity of all three compounds was estimated by using the comet assay in human peripheral blood lymphocytes (PBL) proliferating in vitro. We demonstrated that in contrast to the previously studied anaesthetics, sevoflurane did not induce any increase in DNA migration in the studied conditions. To estimate a genotoxic effect of a prolonged exposure to halogenated anaesthetics in vivo, PBL taken from operating room personnel (n = 29) were tested for DNA degradation and compared with those from a control non-exposed group (n = 20). No significant differences were detected between the groups. We conclude that sevoflurane does not have genotoxic properties, both in vitro and in vivo.
journal_name
J Appl Genetjournal_title
Journal of applied geneticsauthors
Szyfter K,Szulc R,Mikstacki A,Stachecki I,Rydzanicz M,Jałoszyński Psubject
Has Abstractpub_date
2004-01-01 00:00:00pages
369-74issue
3eissn
1234-1983issn
2190-3883pii
221journal_volume
45pub_type
杂志文章abstract::The matrix metalloproteinase-2 gene (MMP2) was found to be associated with hip structure in pigs. Recently three quantitative trait loci (QTLs) for loin muscle area were found on chromosome 6, to which MMP2 was mapped. In the present study, association analyses were conducted in two pig populations for a single-nucleo...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03195679
更新日期:2009-01-01 00:00:00
abstract::This review presents the basic problems and currently available molecular techniques used for genetic profiling in disaster victim identification (DVI). The environmental conditions of a mass disaster often result in severe fragmentation, decomposition and intermixing of the remains of victims. In such cases, traditio...
journal_title:Journal of applied genetics
pub_type: 杂志文章,评审
doi:10.1007/s13353-011-0068-7
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abstract::Myostatin (GDF-8) is a key protein responsible for skeletal muscle growth and development, thus mutations in the mstn gene can have major economic and breeding consequences. The aim of the present study was to investigate myostatin gene expression and transcriptional profile in skeletal muscle of Holstein-Friesian (Bl...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03195620
更新日期:2008-01-01 00:00:00
abstract::This study aimed to determine the frequency of associated urological abnormalities in children with unilateral renal agenesis (RA) or multicystic dysplastic kidney (MCDK). In total, 38 children (10 girls, 28 boys) were studied: 21 with RA and 17 with MCDK. In 14 children (37%) anomalies of the urinary tract were suspe...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03194618
更新日期:2006-01-01 00:00:00
abstract::Arylamine N-acetyltransferase (NAT) genes were targeted for inhibition using short hairpin RNA (shRNA) using two different RNA polymerase III promoters. Constructs were developed for NAT1 and NAT2, the endogenous mouse genes, and for human NAT1. There were fetal and neonatal deaths with these constructs, perhaps due i...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::Proper epigenetic regulation processes are crucial in the normal development of the human brain. An ever-increasing group of neurodevelopmental disorders due to derangements of epigenetic regulation involve both microdeletion and monogenic syndromes. Some of these syndromes have overlapping clinical phenotypes due to ...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-017-0408-3
更新日期:2017-11-01 00:00:00
abstract::Rapid growth in broilers is associated with susceptibility to metabolic disorders such as pulmonary hypertension syndrome (ascites) and sudden death. This study describes a genome search for QTL associated with relative weight of cardio respiratory and metabolically important organs (heart, lungs, liver and gizzard), ...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-015-0325-2
更新日期:2016-05-01 00:00:00
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journal_title:Journal of applied genetics
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract::The white coat colour of sheep is an important economic trait. For unknown reasons, some animals are born with, and others develop with time, black skin spots that can also produce pigmented fibres. The presence of pigmented fibres in the white wool significantly decreases the fibre quality. The aim of this work was t...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-011-0066-9
更新日期:2012-02-01 00:00:00
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journal_title:Journal of applied genetics
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journal_title:Journal of applied genetics
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更新日期:2013-02-01 00:00:00
abstract::The bovine growth hormone receptor (GHR) gene has been identified as a strong positional and functional candidate gene influencing milk production. A non-synonymous single nucleotide polymorphism (SNP) in exon 8 leads to a phenylalanine to tyrosine amino acid substitution (F279Y) in the receptor. The aim of the study ...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-011-0051-3
更新日期:2011-11-01 00:00:00
abstract::Mutagenicity refers to the induction of permanent changes in the DNA sequence of an organism, which may result in a heritable change in the characteristics of living systems. Antimutagenic agents are able to counteract the effects of mutagens. This group of agents includes both natural and synthetic compounds. Based o...
journal_title:Journal of applied genetics
pub_type: 杂志文章,评审
doi:10.1007/s13353-014-0198-9
更新日期:2014-05-01 00:00:00
abstract::Phenylketonuria (PKU) is a metabolic disease caused by mutations in the phenylalanine hydroxylase (PAH) gene. Although the PAH genotype remains the main determinant of PKU phenotype severity, genotype-phenotype inconsistencies have been reported. In this study, we focused on unanalysed sequences in non-coding PAH gene...
journal_title:Journal of applied genetics
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doi:10.1007/s13353-016-0359-0
更新日期:2017-02-01 00:00:00
abstract::A simplified AFLP method, based on methylation-sensitive Alw44I restriction endonuclease, has been developed and evaluated for fingerprinting 15 wheat cultivars. The selected germplasms represented groups of spring and winter wheats with and without the 1BL.1RS translocation. Ten selective primers yielded 57 markers, ...
journal_title:Journal of applied genetics
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doi:
更新日期:2004-01-01 00:00:00
abstract::The distinctness, uniformity and stability (DUS) requirements involve expensive, space- and time-consuming measurements of morphological traits. Moreover, for a majority of traits, interactions between genotype and environment complicate the evaluation. Molecular markers have a potential to facilitate this procedure, ...
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doi:10.1007/BF03195609
更新日期:2008-01-01 00:00:00
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journal_title:Journal of applied genetics
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更新日期:2005-01-01 00:00:00
abstract::Recently, leaf rust and yellow rust caused by the fungi Puccinia triticina Erikss. and P. striiformis Westend f. sp. tritici Eriks and Henn are diseases of increasing threat in triticale (× Triticosecale Wittmack, AABBRR, 2n = 6x = 42) growing areas. The use of genetic resistance is considered the most economical, eff...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-020-00562-8
更新日期:2020-09-01 00:00:00
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journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-012-0105-1
更新日期:2012-11-01 00:00:00
abstract::Myogenic factor 5 (myf-5) is the product of the MYF5 gene, belonging to the MyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene: A65C, C580T and C613T. The aim of this study was to evaluate the influence of the A65C transver...
journal_title:Journal of applied genetics
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journal_title:Journal of applied genetics
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doi:10.1007/s13353-015-0309-2
更新日期:2016-05-01 00:00:00
abstract::The psbA-trnH intergenic region is among the most variable regions in the gymnosperm chloroplast genome. It is proposed as suitable for DNA barcoding studies and is useful in phylogenetics at the species level. This region consists of two parts differing in their evolutionary characteristics: 1) the psbA 3’UTR (...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03208855
更新日期:2010-01-01 00:00:00
abstract::Relationship coefficients are particularly useful to improve genetic management of endangered populations. These coefficients are traditionally based on pedigree data, but in case of incomplete or inexistent pedigrees they are replaced by coefficients calculated from molecular data. The main objective of this study wa...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03195664
更新日期:2009-01-01 00:00:00
abstract::Niemann-Pick type C1 (NPC) disease is an autosomal recessive neurodegenerative disorder. One feature of the mouse model of NPC1 is it's infertility. We have made transgenic mice which express the Npc1 protein exclusively in fibrillary astrocytes, using the glial fibrillary acidic protein (GFAP) promoter. This selectiv...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03195698
更新日期:2009-01-01 00:00:00
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journal_title:Journal of applied genetics
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doi:10.1007/s13353-019-00517-8
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abstract::Gaucher disease (GD) is an autosomal recessive inborn error of metabolism, resulting from a deficiency of the enzyme glucocerebrosidase, causing an accumulation of the glycolipid glucocerebroside within lysosomes of macrophages in the reticuloendothelial system. Three major clinical forms have been assigned and more t...
journal_title:Journal of applied genetics
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doi:10.1007/BF03195642
更新日期:2008-01-01 00:00:00
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journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/BF03195710
更新日期:2010-01-01 00:00:00
abstract::Polymorphisms in the coding region of the prion protein gene (PRNP) have been associated with the susceptibility and incubation period of prion diseases in humans and sheep. However, polymorphisms in this part of the bovine PRNP gene do not affect the classical bovine spongiform encephalopathy (BSE) susceptibility in ...
journal_title:Journal of applied genetics
pub_type: 杂志文章
doi:10.1007/s13353-012-0102-4
更新日期:2012-08-01 00:00:00