Cellular mucosal defense is attenuated with chronicity of Helicobacter pylori infection.

abstract：:The present study aimed to investigate the role of nitric oxide on the oxidative damage in isolated rabbit gastric cells exposed to hypoxia-reoxygenation. Nitric oxide synthesis modulators such as L-arginine and NG-nitro-L-arginine methyl ester, a nitric oxide donor, sodium nitroprusside, and superoxide dismutase were...

journal_title：Digestive diseases and sciences

authors： Kim H,Kim KH

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is a common malignancy worldwide with poor outcomes. Therefore, it is important to identify a valuable prognostic biomarker for HCC. The present study aimed to identify novel prognostic biomarkers for HCC and evaluate the potential role of hub genes in HCC. METHODS:Weighted ge...

journal_title：Digestive diseases and sciences

authors： Wu M,Jiang L

更新日期：2021-01-26 00:00:00

abstract：:Helicobacter pylori infection has been linked with gastric carcinoma. Epithelial cell proliferation is an indicator of cancer risk. The aim of this study was to assess gastric epithelial cell proliferation before and after eradication therapy and to assess the efficacy of treatment of H. pylori infection using lanzopr...

journal_title：Digestive diseases and sciences

authors： Cahill RJ,Xia H,Kilgallen C,Beattie S,Hamilton H,O'Morain C

更新日期：1995-08-01 00:00:00

abstract：:Isoamylase distribution in the urine of normal individuals and patients admitted to the hospital with hyperamylasemia was determined by a wheat inhibitor mmethod and compared to results obtained by cellulose-acetate electrophoresis. We report two cases where the inhibitor ethod failed to give accurate results in urine...

journal_title：Digestive diseases and sciences

authors： Gersten M,Bank S,Lendvai S

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) is the number one cause of liver disease in the United States. The prevalence rates in African Americans (AA), while significantly lower than other ethnic groups with similar known risk factors, have been quoted as high as 24 %. We aim to determine if the pre...

journal_title：Digestive diseases and sciences

authors： Foster T,Anania FA,Li D,Katz R,Budoff M

更新日期：2013-08-01 00:00:00

abstract：:Pancreatic function tests were performed in 11 adult cystic fibrosis (CF) patients with a fecal fat excretion of more than 10% during treatment with pancrease 2 capsules three times a day. These tests included urinary p-aminobenzoic acid (PABA) excretion, fasting serum trypsin and pancreatic polypeptide (PP), and gluc...

journal_title：Digestive diseases and sciences

authors： Heijerman HG,Lamers CB,Bakker W,Dijkman JH

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Peppermint oil is well known to inhibit smooth muscle contractions, and its topical administration during colonoscopy is reported to reduce colonic spasms. AIMS:We aimed to assess whether oral administration of IBGard™, a sustained-release peppermint oil formulation, before colonoscopy reduces spasms and im...

journal_title：Digestive diseases and sciences

authors： Han JY,Moosvi Z,Duh E,Park S,Albers GC,Samarasena JB,Karnes W

更新日期：2020-06-09 00:00:00

abstract：BACKGROUND:Numerous experiments have shown that alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are present in cells of various cancer and can play role in carcinogenesis. In previous investigations we have found elevated levels of alcohol dehydrogenase class III activity in pancreatic cancer cells. It ca...

journal_title：Digestive diseases and sciences

authors： Jelski W,Zalewski B,Szmitkowski M

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Defective autophagic machinery, such as that in Crohn's disease patients homozygous for ATG16L1 risk allele, is associated with alteration of resident gut bacterial communities. However, whether or not host autophagy responds to changes in the resident gut microbial community is not known. Here, we investiga...

journal_title：Digestive diseases and sciences

authors： Singh SB,Wilson M,Ritz N,Lin HC

更新日期：2017-06-01 00:00:00

abstract：:H. pylori may colonize columnar-lined esophagus, although an etiologic role in esophageal adenocarcinoma is unproven. H. pylori can adhere to intestinal metaplasia in the stomach. This study was designed to examine if H. pylori adheres to specialized intestinal metaplasia in columnar-lined esophagus. Esophageal biopsi...

journal_title：Digestive diseases and sciences

authors： Sharma VK,Demian SE,Taillon D,Vasudeva R,Howden CW

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is a common disease with intestinal dysmotility, whose mechanism remains elusive. TMEM16A is a calcium-activated chloride channel (CaCC) involved in intestinal slow-wave generation. AIMS:To investigate whether TMEM16A is involved in colonic dysmotility in IBS. METHODS:A rat m...

journal_title：Digestive diseases and sciences

authors： Lin MJ,Yu BP

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Microscopic colitis typically presents with chronic watery nonbloody diarrhea with normal endoscopy findings but abnormal inflammatory histopathological findings. As it is mainly a condition of the elderly, pediatric data is scarce. AIMS:To describe and characterize children with microscopic colitis. METHO...

journal_title：Digestive diseases and sciences

authors： El-Matary W,Girgis S,Huynh H,Turner J,Diederichs B

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Antiviral therapy in addition to immunoprophylaxis at birth has been shown to further reduce perinatal transmission of hepatitis B virus (HBV) in highly viremic women. AIMS:The aim of this study was to describe the use of tenofovir disoproxil fumarate (TDF) prophylaxis to reduce maternal HBV DNA levels and ...

journal_title：Digestive diseases and sciences

authors： Tsai PJ,Chang A,Yamada S,Tsai N,Bartholomew ML

更新日期：2014-11-01 00:00:00

abstract：:A pathogenic role of nitric oxide has been suggested in acute and chronic intestinal inflammation. We took the opportunity offered by studies in patients with excluded colon, which represents a model of chronic intestinal inflammation with no exogenous nitrite or nitrate supply, to evaluate the quantity and the qualit...

journal_title：Digestive diseases and sciences

authors： Neut C,Guillemot F,Colombel JF

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:The chemokine SDF-1 and its receptor CXCR4 are essential for the proper functioning of multiple organs. In the liver, cholangiocytes and hepatic progenitor cells (HPCs) are the main cells that produce SDF-1, and SDF-1 is thought to be essential for HPC-stimulated liver regeneration. AIMS:In this study, CXCR...

journal_title：Digestive diseases and sciences

authors： Tsuchiya A,Imai M,Kamimura H,Takamura M,Yamagiwa S,Sugiyama T,Nomoto M,Heike T,Nagasawa T,Nakahata T,Aoyagi Y

更新日期：2012-11-01 00:00:00

abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...

journal_title：Digestive diseases and sciences

authors： Mak LY,Liu SH,Yap DY,Seto WK,Wong DK,Fung J,Chan TM,Lai CL,Yuen MF

更新日期：2019-12-01 00:00:00

abstract：:We studied the effects of an ileocolonic sphincter substitute on canine small intestine motor activity. Recordings of fasting and postprandial myoelectrical activity were performed in three groups of animals in whom the following procedures had been performed: (1) electrode placement alone, intestinal continuity undis...

journal_title：Digestive diseases and sciences

authors： Quigley EM,Thompson JS,Lof J

更新日期：1989-09-01 00:00:00

abstract：:Minimal hepatic encephalopathy (MHE) is characterized by disturbance of mental state and neuromuscular function. To assess the clinical efficacy of acetyl-L: -carnitine (ALC) in the treatment of MHE, we performed a randomized, double-blind, placebo-controlled study administering ALC in cirrhotic patients with this dis...

journal_title：Digestive diseases and sciences

authors： Malaguarnera M,Gargante MP,Cristaldi E,Vacante M,Risino C,Cammalleri L,Pennisi G,Rampello L

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Natural language processing is a powerful technique of machine learning capable of maximizing data extraction from complex electronic medical records. METHODS:We utilized this technique to develop algorithms capable of "reading" full-text radiology reports to accurately identify the presence of fatty live...

journal_title：Digestive diseases and sciences

authors： Redman JS,Natarajan Y,Hou JK,Wang J,Hanif M,Feng H,Kramer JR,Desiderio R,Xu H,El-Serag HB,Kanwal F

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND AND AIM:Population-based endoscopic studies of esophageal eosinophilia and eosinophilic esophagitis are limited in the world. This study was aiming to describe features of esophageal eosinophilia and eosinophilic esophagitis in a representative sample of the adult in Shanghai, China. METHODS:As part of a la...

journal_title：Digestive diseases and sciences

authors： Ma X,Xu Q,Zheng Y,Zhao Y,Lu J,Wang R,Li Z,Zou D,He J

更新日期：2015-06-01 00:00:00

abstract：:Left-sided portal hypertension is a rare clinical syndrome which may lead to bleeding from isolated gastric varices. Pancreatic disease is the most common etiology. Left-sided portal hypertension should be considered in the presence of gastrointestinal bleeding with normal liver function and unexplained splenomegaly. ...

journal_title：Digestive diseases and sciences

authors： Köklü S,Coban S,Yüksel O,Arhan M

更新日期：2007-05-01 00:00:00

abstract：:Previous studies have found a widely variable prevalence of dysplasia and cancer in colonic strictures in patients with ulcerative colitis. Consequently, therapeutic recommendations are conflicting. To better assess the prevalence, we reviewed the clinical and pathological findings in all 27 patients with ulcerative c...

journal_title：Digestive diseases and sciences

authors： Lashner BA,Turner BC,Bostwick DG,Frank PH,Hanauer SB

更新日期：1990-03-01 00:00:00

abstract：:To evaluate the influence of chronic alcoholism on clinical features of chronic pancreatitis in Japan, pain evolution, pancreatic insufficiency, and long-term prognosis were studied by comparing chronic alcoholic pancreatitis (N = 88) with idiopathic pancreatitis (N = 67). The 155 patients with known course of the dis...

journal_title：Digestive diseases and sciences

authors： Hayakawa T,Kondo T,Shibata T,Sugimoto Y,Kitagawa M

更新日期：1989-01-01 00:00:00

abstract：:Cyclic vomiting syndrome is a disorder characterized by recurrent episodes of nausea and vomiting with complete resolution of symptoms between attacks. Nitric oxide plays a critical role in regulating several components of gastrointestinal mucosal defense and injury. Interleukin-6 has a wide variety of actions in the ...

journal_title：Digestive diseases and sciences

authors： Zicari A,Corrado G,Pacchiarotti C,Lucarelli S,Frediani T,Cavaliere M,Porcelli M,Cardi E

更新日期：2001-04-01 00:00:00

abstract：:Management of pancreatic cystic lesions relies on patients' clinical presentation, imaging, and endoscopic ultrasound. Current research in basic science, radiology, and endoscopy is evolving and making progress in this condition which is relatively common in the general population. This review focuses on the recent en...

journal_title：Digestive diseases and sciences

authors： Bartel MJ,Raimondo M

更新日期：2017-07-01 00:00:00

abstract：:Endoscopic photodynamic therapy with hematoporphyrin derivative was used in the primary treatment of 54 patients with inoperable gastrointestinal neoplasms. Patients were divided into three groups including 24 with esophageal squamous cell carcinoma, 14 with adenocarcinoma of the stomach or lower third of the esophagu...

journal_title：Digestive diseases and sciences

authors： Patrice T,Foultier MT,Yactayo S,Adam F,Galmiche JP,Douet MC,Le Bodic L

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:The majority of ghrelin producing cells (GPC) are present in the fundic gland of the stomach and recognized as X/A like cells. The detailed distribution of GPC in the stomach is still unknown in healthy and pathological subjects. METHODS:We investigated the detailed distribution of GPC in the stomach, especi...

journal_title：Digestive diseases and sciences

authors： Takiguchi S,Adachi S,Yamamoto K,Morii E,Miyata H,Nakajima K,Yamasaki M,Kangawa K,Mori M,Doki Y

更新日期：2012-05-01 00:00:00

abstract：AIMS:The purpose of this retrospective study was to assess clinical outcomes of endoscopic bougie dilation of esophageal strictures after radiation therapy for head and neck cancer, and to assess the risk factors which affect the treatment success. METHODS:Thirty-one patients with esophageal stricture due to radiation...

journal_title：Digestive diseases and sciences

authors： Tuna Y,Koçak E,Dinçer D,Köklü S

更新日期：2012-02-01 00:00:00

abstract：:We examined the effect of interleukin-1beta (IL-1beta) on spontaneous and enhanced restoration (cell migration and proliferation) using an in vitro wound model comprising a confluent monolayer of rat gastric epithelial RGM1 cells. Repair of an artificial wound in a cell monolayer was found to be time- and concentratio...

journal_title：Digestive diseases and sciences

authors： Nakamura E,Takahashi S,Matsui H,Okabe S

更新日期：1998-03-01 00:00:00

abstract：:The purpose of this study was to investigate the potential of a computerized auscultation method for providing an objective, quantitative measure characteristic of irritable bowel syndrome. Bowel sounds from irritable bowel patients and normal controls were digitized using an electronic stethoscope. Computerized analy...

journal_title：Digestive diseases and sciences

authors： Craine BL,Silpa M,O'Toole CJ

更新日期：1999-09-01 00:00:00