Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome Is Associated with Upregulation of TMEM16A in Myenteric Plexus.

abstract：:This study was designed to evaluate the role of 111In-labeled leukocyte imaging and fecal excretion in the assessment of inflammatory bowel disease. We compared these tests to various indices of disease activity in Crohn's disease, to Truelove's grading in ulcerative colitis, and to endoscopy, x-ray, and pathology in ...

journal_title：Digestive diseases and sciences

authors： Leddin DJ,Paterson WG,DaCosta LR,Dinda PK,Depew WT,Markotich J,McKaigney JP,Groll A,Beck IT

更新日期：1987-04-01 00:00:00

abstract：:Achalasia has been described following fundoplication and is attributed to vagal nerve damage during surgery. Similarly, other traumatic events to the distal esophagus may be linked to the development of achalasia. Operative and nonoperative trauma as a possible factor in the development of achalasia was studied. A re...

journal_title：Digestive diseases and sciences

authors： Shah RN,Izanec JL,Friedel DM,Axelrod P,Parkman HP,Fisher RS

更新日期：2004-11-01 00:00:00

abstract：:We report a rare case of secondary involvement of the gallbladder by metastatic renal cell carcinoma. A 71-year-old man was diagnosed as having a polypoid mass within the gallbladder when he underwent right nephrectomy for a renal cell carcinoma. A preoperative diagnosis of simultaneous carcinoma of the gallbladder wa...

journal_title：Digestive diseases and sciences

authors： Satoh H,Iyama A,Hidaka K,Nakashiro H,Harada S,Hisatsugu T

更新日期：1991-04-01 00:00:00

abstract：:We have developed an improved semiconductor recording probe for monitoring motility of the upper small intestine in humans. The probe consists of six ultraminiature silicon pressure sensors spaced 10 cm apart and encased in a flexible polyurethane sheath. The probe is small [2.67 mm (8F) diameter], is easily passed tr...

journal_title：Digestive diseases and sciences

authors： Mathias JR,Sninsky CA,Millar HD,Clench MH,Davis RH

更新日期：1985-02-01 00:00:00

abstract：:Ninety-one patients with idiopathic constipation had segmental colonic transit studied with radiopaque markers using a new simplified technique to determine frequency and type of colonic transit time (CTT) abnormalities and to determine the utility of this test in planning therapy. Colonic transit studies defined four...

journal_title：Digestive diseases and sciences

authors： Chaussade S,Khyari A,Roche H,Garret M,Gaudric M,Couturier D,Guerre J

更新日期：1989-08-01 00:00:00

abstract：:Among 56 cases who presented to Kanto-Teishin Hospital complaining of bloody diarrhea or considerable hematochezia of acute onset, 8 cases (14.3%) were considered due to colitis associated with oral ampicillin therapy. The bloody diarrhea, often with abdominal cramps, began 2-7 days after starting the treatment. The d...

journal_title：Digestive diseases and sciences

authors： Sakurai Y,Tsuchiya H,Ikegami F,Funatomi T,Takasu S,Uchikoshi T

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Recent data suggest the involvement of both the adaptive and the innate immune system in celiac disease (CD). However, little is known about the immune phenotype of children with CD and its alteration upon dietary intervention. AIMS:We characterized the prevalence of major interacting members of the adaptiv...

journal_title：Digestive diseases and sciences

authors： Cseh Á,Vásárhelyi B,Szalay B,Molnár K,Nagy-Szakál D,Treszl A,Vannay Á,Arató A,Tulassay T,Veres G

更新日期：2011-03-01 00:00:00

abstract：:The effects of intestinal resection on several intestinal parameters have been studied in the large intestine of rats one month after the surgical operation. The results show that both 50% and 80% distal small bowel resection increased net fluid absorption and mucosal permeability and caused expansion of the intercell...

journal_title：Digestive diseases and sciences

authors： Vázquez CM,Molina MT,Ilundaín A

更新日期：1989-11-01 00:00:00

abstract：:The authors have developed a primate model for evaluating cytoprotection against alcohol-induced injury in gastric mucosa pretreated with antiulcer agents. In the present study, groups of squirrel monkeys received either a single oral dose of misoprostol (500 or 200 micrograms/kg), cimetidine (3 or 6 mg/kg), placebo, ...

journal_title：Digestive diseases and sciences

authors： Liss RH,Letourneau RJ,Schepis JP

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Gastroparesis is a heterogeneous disorder. Patient characteristics and treatment responsiveness may differ based on the extent of delay in gastric emptying. AIMS:Characterize gastroparesis patients based on the degree of delay in gastric emptying, and assess the relationship of patient demographics, symptom...

journal_title：Digestive diseases and sciences

authors： Navas CM,Wadas ED,Zbib NH,Crowell MD,Lacy BE

更新日期：2020-04-18 00:00:00

abstract：:Left-sided portal hypertension is a rare clinical syndrome which may lead to bleeding from isolated gastric varices. Pancreatic disease is the most common etiology. Left-sided portal hypertension should be considered in the presence of gastrointestinal bleeding with normal liver function and unexplained splenomegaly. ...

journal_title：Digestive diseases and sciences

authors： Köklü S,Coban S,Yüksel O,Arhan M

更新日期：2007-05-01 00:00:00

abstract：:This study was designed to determine the possible effects of omeprazole on human natural killer cells. Peripheral venous blood samples were taken from 20 peptic ulcer patients before and at the 14th and the 28th days of omeprazole treatment. Mononuclear cells were removed from blood and their capability of making conj...

journal_title：Digestive diseases and sciences

authors： Alkim H,Unal S,Okur H,Imir T

更新日期：2008-02-01 00:00:00

abstract：:Achalasia is an esophageal motility disorder of unknown etiology. Several studies suggest possible herpes or measles virus etiology, but results are inconclusive. The aim of this study was to test whether herpesvirus (HV), measles (MV), or human papilloma virus (HPV) sequences could be detected in myotomy specimens fr...

journal_title：Digestive diseases and sciences

authors： Birgisson S,Galinski MS,Goldblum JR,Rice TW,Richter JE

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:New molecular biology-based methods of bacterial identification are expected to help elucidate the relationship between colorectal cancer (CRC) and intestinal microbiota. Although there is increasing evidence revealing the potential role of microbiota in CRC, it remains unclear whether microbial dysbiosis is...

journal_title：Digestive diseases and sciences

authors： Ohigashi S,Sudo K,Kobayashi D,Takahashi O,Takahashi T,Asahara T,Nomoto K,Onodera H

更新日期：2013-06-01 00:00:00

abstract：:Glutamine synthetase is responsible for the ATP-dependent amidation of glutamate to glutamine. In liver the enzyme is highly localized in perivenous hepatocytes; in brain the enzyme is localized in astrocytes. Portacaval anastomosis resulted in liver atrophy, hyperammonemia, and up to 90% loss of glutamine synthetase ...

journal_title：Digestive diseases and sciences

authors： Girard G,Butterworth RF

更新日期：1992-07-01 00:00:00

abstract：:The present study reports the results of intravenous cyclosporine in 32 patients with refractory and/or severe attacks of ulcerative colitis (UC). Twenty of 32 patients responded to intravenous cyclosporine; cyclosporine was clinically effective and improved colonic lesions. However, one colonic perforation and one po...

journal_title：Digestive diseases and sciences

authors： Carbonnel F,Boruchowicz A,Duclos B,Soulé JC,Lerebours E,Lémann M,Belaïche J,Colombel JF,Cosnes J,Gendre JP

更新日期：1996-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) arises from a number of cirrhosis-related and non-cirrhosis-related exposures and is one of the leading causes of cancer-related deaths worldwide. Achieving a durable cure currently relies on either resection or transplantation, but since most patients will be diagnosed with inoperable d...

journal_title：Digestive diseases and sciences

authors： Saffo S,Taddei TH

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Assessment of whole gut transit, by radio-opaque markers or scintigraphy, is used to evaluate patients with constipation for slow gastrointestinal transit. Wireless capsule motility, using the SmartPill GI monitoring system, samples and transmits intraluminal pH, pressure, and temperature data from a capsu...

journal_title：Digestive diseases and sciences

authors： Maqbool S,Parkman HP,Friedenberg FK

更新日期：2009-10-01 00:00:00

abstract：AIM:Renal toxicity of adefovir disoproxil (ADV) and tenofovir disoproxil fumarate (TDF) is a significant concern in chronic hepatitis B (CHB) patients. Early observational clinical data suggested that telbivudine (LdT) might have renoprotective effects. METHODS:In this prospective study, consecutive CHB patients on co...

journal_title：Digestive diseases and sciences

authors： Mak LY,Liu SH,Yap DY,Seto WK,Wong DK,Fung J,Chan TM,Lai CL,Yuen MF

更新日期：2019-12-01 00:00:00

abstract：:The purpose of this study was to investigate the histogenesis of experimental tumors in the rat esophagus. Thirty rats received 0.0015% N-methyl-N-amylnitrosamine (MNAN) in the drinking water for 12 weeks. Another 30 rats received tap water. All rats then received tap water until sacrifice. Rats from each group were s...

journal_title：Digestive diseases and sciences

authors： Kuwayama H,Eastwood GL

更新日期：1988-01-01 00:00:00

abstract：:Emodin inhibited expression of both transforming growth factor beta1 (TGFbeta1)- and phorbol ester (PMA)-induced tissue inhibitors of metalloproteinase-1 (TIMP-1) in an immortalized rat hepatic stellate cell line, HSC-T6, by Western blot and reverse transcription polymerase chain reaction. Reporter gene assays showed ...

journal_title：Digestive diseases and sciences

authors： Gui M,Zhang YF,Xiao ZY,Sun P,Dai JF,Wang SF,Rui YC,Zhang JP

更新日期：2007-01-01 00:00:00

abstract：:A series of in vitro experiments was performed to test the ability of bovine and human lactoferrin to influence the growth of the gram-positive probiotic bacteria, Bifidobacterium bifidum, Bifidobacterium infantis, and Lactobacillus acidophilus, as well as the gram-negative enteric bacteria, E. coli O157:H7 and Salmon...

journal_title：Digestive diseases and sciences

authors： Griffiths EA,Duffy LC,Schanbacher FL,Dryja D,Leavens A,Neiswander RL,Qiao H,DiRienzo D,Ogra P

更新日期：2003-07-01 00:00:00

abstract：:Our purpose was to observe the effects of sodium phosphate (NaP) colonoscopy preparation on serum electrolytes, phosphate, and calcium and to identify factors associated with any adverse effects. In an unselected group of 100 consecutive patients attending for out patient colonoscopy, 45% of patients had raised serum ...

journal_title：Digestive diseases and sciences

authors： Ainley EJ,Winwood PJ,Begley JP

更新日期：2005-07-01 00:00:00

abstract：:A three-year prospective study was conducted to assess the efficacy and safety of transjugular liver biopsy with a Trucut-type needle employing an automated device. Fifty-two consecutive patients (39 women and 13 men), ages 46.3+/-14.6 years, in whom percutaneous liver biopsy was contraindicated were included in the s...

journal_title：Digestive diseases and sciences

authors： De Hoyos A,Loredo ML,Martínez-Ríos MA,Gil MR,Kuri J,Cárdenas M

更新日期：1999-01-01 00:00:00

abstract：:The mechanisms of pentagastrin-induced gastric mucosal blood flow (GMBF) response were investigated in anesthetized rats. A rat stomach was mounted on an ex vivo chamber, perfused with saline, and GMBF was measured by a laser Doppler flowmetry simultaneously with acid secretion. Pentagastrin infused intravenously prod...

journal_title：Digestive diseases and sciences

authors： Kato S,Okabe S,Takeuchi K

更新日期：1996-03-01 00:00:00

abstract：:Epidemiologic data have shown that cholecystectomy is associated with a moderately increased risk of esophageal adenocarcinoma. The study objective was to evaluate the role of refluxed bile. A total of 696 patients with upper gastrointestinal symptoms were included in the study, of whom 55 had a history of cholecystec...

journal_title：Digestive diseases and sciences

authors： Fein M,Bueter M,Sailer M,Fuchs KH

更新日期：2008-05-01 00:00:00

abstract：:Lichen planus is a common mucocutaneus disorder that rarely involves the esophagus. We report two challenging cases presenting with recurrent dysphagia originally suspected due to gastroesophageal reflux. Subsequent evaluation revealed peculiar endoscopic findings of desquamative esophagitis leading to the diagnosis o...

journal_title：Digestive diseases and sciences

authors： Ukleja A,DeVault KR,Stark ME,Achem SR

更新日期：2001-10-01 00:00:00

abstract：:A 36-year-old female with a six-year history of Crohn's disease of the anus and colon was found to have in situ cloacogenic carcinoma of the anus after having undergone total proctocolectomy for massive bleeding. This case further supports the association between Crohn's disease of the gastrointestinal tract and its p...

journal_title：Digestive diseases and sciences

authors： Daly JJ,Madrazo A

更新日期：1980-06-01 00:00:00

abstract：:The release of intestinal gastrin was examined using the isolated vascularly and luminally perfused rat duodenum. Results show that duodenal gastrin was released into both the intestinal lumen and circulation. The basal release of immunoreactive gastrin (IRG) into the lumen was 23.3 +/- 1.8 pg/min and that into the va...

journal_title：Digestive diseases and sciences

authors： Fujimiya M,Kwok YN

更新日期：1997-03-01 00:00:00

abstract：:We examined the role of capsaicin-sensitive afferent neurons in pH-dependent gastrin secretion in the rat stomach. The change in serum gastrin levels relative to changes in luminal pH (using omeprazole for luminal alkalization or 0.1 N HCl for luminal acidification) was studied after oral administration of 4% lidocain...

journal_title：Digestive diseases and sciences

authors： Nojima K,Sumii K,Sumii M,Okahara S,Haruma K,Yoshihara M,Kajiyama G

更新日期：2000-06-01 00:00:00