Abstract:
:Second-generation dendrimers have been prepared on solid phase by successive additions of branched polyproline building blocks starting from two different branching units anchored to the solid support. The preparation of Pro-rich building blocks was carried out by stepwise solid-phase synthesis and their iterative addition was performed by a convergent approach, also using solid-phase synthesis. cis-4-Amino-L-proline and imidazolidine-2-carboxylic acid were used as branching units due to their structural resemblance to proline. The optimized strategy allowed the target compounds to be obtained with high purities without the need for purification steps.
journal_name
Biopolymersjournal_title
Biopolymersauthors
Sanclimens G,Crespo L,Giralt E,Royo M,Albericio Fdoi
10.1002/bip.20125subject
Has Abstractpub_date
2004-01-01 00:00:00pages
283-97issue
4eissn
0006-3525issn
1097-0282journal_volume
76pub_type
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