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Comorbidity independently predicted death in older prostate cancer patients, more of whom died with than from their disease.

Abstract：

OBJECTIVE:The purpose of this study was to examine the proportion of men who died from prostate cancer (PrCa) vs. with PrCa and assess the comorbid conditions associated with other-cause deaths. STUDY DESIGN AND SETTING:We identified all male decedents aged >/=65 years in Jefferson County, AL, in 1993-1995. By crosslinking three databases (death certificate, Medicare, and Veteran's Administration), we identified men whose deaths might have been caused by PrCa. We abstracted and reviewed medical records to rate comorbid conditions and determine whether or not death was due to PrCa. RESULTS:Of 561 men with a premortem diagnosis of PrCa, 42% died from PrCa and 53% died with PrCA; 50.2% of blacks died from PrCa vs. 36.9% of Whites. Other factors related to dying with PrCa included older age at death and a serious, or very serious, comorbid condition. Treatment did not have an independent effect on cause of death (i.e., death with vs. from PrCa). CONCLUSIONS:Comorbidity was an independent predictor of dying with PrCa, even after adjustment for ethnicity, age, and treatment. Given the as yet unproven benefit of PrCa screening, our results extend the body of information relevant to the screening decision; among men dying with a diagnosis of PrCa, only about 1/3 to 1/2 died from the disease.

journal_name

J Clin Epidemiol

journal_title

Journal of clinical epidemiology

authors

Fouad MN,Mayo CP,Funkhouser EM,Irene Hall H,Urban DA,Kiefe CI

doi

10.1016/j.jclinepi.2003.11.009

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

721-9

issue

7

eissn

0895-4356

issn

1878-5921

pii

S0895435603004268

journal_volume

57

pub_type

杂志文章

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