Reporting of trials presented in conference abstracts needs to be improved.


OBJECTIVES:To assess how trial information reported in conference abstracts differs to their subsequent full publication. METHODS:Randomized trials reported at the American Society of Clinical Oncology conference (1992) were identified. CENTRAL and PubMed (December 2002) were searched to identify corresponding full publications. A checklist (based on CONSORT) was used to compare abstracts for 37 trials with their full publication. RESULTS:Some aspects were well reported. Ninety-five percent of study objectives, 92% of participant eligibility, 100% of trial interventions, and 84% of primary outcomes were the same in both abstract and full publication. Other areas were more discrepant. Forty-six percent reported the same number of participants randomized in the abstract and full publication; only 22% reported the same number analyzed (median number analyzed per trial was 96 for abstracts and 117 for full publications). Eighty-two percent of trials were closed to follow-up in the full publication compared to 19% of abstracts. Lack of information was a major problem in assessing trial quality: no abstracts reported on allocation concealment, 16% reported on blinding and 14% reported intention to treat analysis. These figures were 49, 19, and 46%, respectively, for full publications. CONCLUSION:The information given for trials in conference proceedings can be unstable, especially for trials presenting early or preliminary results, and needs to be improved.


J Clin Epidemiol


Hopewell S,Clarke M,Askie L




Has Abstract


2006-07-01 00:00:00














  • The level of alcohol consumption at which all-cause mortality is least.

    abstract::Moderate consumers of alcohol have lower mortality than either nondrinkers or heavy drinkers. This systematic review aimed to quantify the level of alcohol consumption (termed the nadir) at which the lowest mortality occurs. Twenty cohort studies reported analyses of all-cause mortality for at least three categories o...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,meta分析


    authors: White IR

    更新日期:1999-10-01 00:00:00

  • Simultaneous interval estimates of the odds ratio in studies with two or more comparisons.

    abstract::More than one odds ratio estimate will often arise from a single epidemiologic study. Examples of designs where this may occur include those where there is more than one case or control group, and investigations of several risk factors as part of the same study. Various methods for presenting multiple interval estimat...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Holford TR,Walter SD,Dunnett CW

    更新日期:1989-01-01 00:00:00

  • Half of Cochrane reviews were published more than 2 years after the protocol.

    abstract:OBJECTIVES:The objective of the study is to examine the time from publication of the protocol for a Cochrane review to publication of the Cochrane review for the entire Cochrane Database of Systematic Reviews (CDSR). STUDY DESIGN AND SETTINGS:Cochrane reviews from the CDSR published between 1995 and 2019 were assessed...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,评审


    authors: Andersen MZ,Gülen S,Fonnes S,Andresen K,Rosenberg J

    更新日期:2020-08-01 00:00:00

  • Application of a sequential t-test in a cohort nested case-control study with multiple controls per case.

    abstract::Application of sequential analysis may avoid unnecessary experimentation and achieve economical use of available biomaterial stored in biological banks. When, as often happens in cohort case-controls studies, cases are scarce, it may be possible to use multiple control observations per case to increase the power of a ...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: van der Tweel I,van Noord PA,Kaaks R

    更新日期:1993-03-01 00:00:00

  • The practice of meta-analysis.

    abstract::Meta-analysis seems to have a potentially useful role in carefully selected situations where the primary literature is of good quality, heterogeneity in the response to treatment of the tested population is small and well-understood, interest centers on estimation of a specific, critical parameter of outcome, and the ...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,评审


    authors: Bailar JC 3rd

    更新日期:1995-01-01 00:00:00

  • Test-retest reliability of an epidemiological instrument for Parkinson's disease.

    abstract::Reliability testing was conducted on a survey instrument for a genetic epidemiological study of Parkinson's disease (PD). Information on demographics, medical history, places of residence, and occupations was collected. The instrument was administered to 11 pairs of siblings discordant for PD and then re-administered ...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Reider CR,Hubble JP

    更新日期:2000-08-01 00:00:00

  • Estimating the contribution of individual risk factors to disease in a person with more than one risk factor.

    abstract::Various measures have been proposed to express the excess risk of an outcome attributable to one particular risk factor, such as attributable risk and risk fraction. However, there is sometimes a need, both in epidemiological studies and in awarding compensation in legal cases, to simultaneously consider the contribut...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: McElduff P,Attia J,Ewald B,Cockburn J,Heller R

    更新日期:2002-06-01 00:00:00

  • Statistical power of clinical trials increased while effect size remained stable: an empirical analysis of 136,212 clinical trials between 1975 and 2014.

    abstract:OBJECTIVES:To study the statistical power of randomized clinical trials and examine developments over time. STUDY DESIGN AND SETTING:We analyzed the statistical power in 136,212 clinical trials between 1975 and 2014 extracted from meta-analyses from the Cochrane database of systematic reviews. We determined study powe...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Lamberink HJ,Otte WM,Sinke MRT,Lakens D,Glasziou PP,Tijdink JK,Vinkers CH

    更新日期:2018-10-01 00:00:00

  • Time-related issues with application to health gains and losses.

    abstract::Time-related aspects of health have attracted increasing interest, and it has become evident that many medical situations concern the exchange of present-day costs for future benefits. Traditional decision analytic paradigms weigh the probability of outcomes and the value of outcomes. Such analyses are incomplete if t...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Ortendahl M,Fries JF

    更新日期:2002-09-01 00:00:00

  • Cochrane Qualitative and Implementation Methods Group guidance series-paper 6: reporting guidelines for qualitative, implementation, and process evaluation evidence syntheses.

    abstract:OBJECTIVES:To outline contemporary and novel developments for the presentation and reporting of syntheses of qualitative, implementation, and process evaluation evidence and provide recommendations for the use of reporting guidelines. STUDY DESIGN AND SETTING:An overview of reporting guidelines for qualitative, implem...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Flemming K,Booth A,Hannes K,Cargo M,Noyes J

    更新日期:2018-05-01 00:00:00

  • In a prospective study in young people, associations between changes in smoking behavior and risk factors for cardiovascular disease were complex.

    abstract:OBJECTIVE:This study investigates how voluntary changes in tobacco consumption are related to changes in biological risk factors for cardiovascular disease in 21- to 36-year-old men and women. STUDY DESIGN AND SETTING:Data of the Amsterdam Growth and Health Longitudinal Study (AGAHLS) were used to study the associatio...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Bernaards CM,Twisk JW,Snel J,van Mechelen W,Kemper HC

    更新日期:2005-11-01 00:00:00

  • A cohort study found that white blood cell count and endocrine markers predicted preterm birth in symptomatic women.

    abstract:OBJECTIVE:This cohort study investigated potential clinical and biochemical predictors of subsequent preterm birth in women presenting with threatened preterm labor. STUDY DESIGN AND SETTING:Subjects were 218 pregnant women admitted to hospital with a diagnosis of threatened preterm labor at 22-36 weeks gestation. Exc...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Campbell MK,Challis JR,DaSilva O,Bocking AD

    更新日期:2005-03-01 00:00:00

  • Standardized physical examination protocol for low back disorders: feasibility of use and validity of symptoms and signs.

    abstract::A standardized examination protocol was developed for the assessment of low back disorders in primary care. The protocol was found feasible in the occupational health service setting. The interexaminer repeatability between an occupational physician and an occupational physiotherapist was good for most items. The pred...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Viikari-Juntura E,Takala EP,Riihimäki H,Malmivaara A,Martikainen R,Jäppinen P

    更新日期:1998-03-01 00:00:00

  • Preliminary observations on maternal rating of health of children: data from three subspecialty clinics.

    abstract::Although routinely used in health surveys, the factors affecting maternal perceptions of health in children, especially those with health problems, have received little examination. This question has been addressed using a telephone interview of families of 483 children followed in one of three clinics at Children's H...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: McCormick MC,Athreya BH,Bernbaum JC,Charney EB

    更新日期:1988-01-01 00:00:00

  • Abbreviated literature searches were viable alternatives to comprehensive searches: a meta-epidemiological study.

    abstract:OBJECTIVE:To assess the effects of abbreviated literature searches on evidence syntheses conclusions. STUDY DESIGN AND SETTING:We randomly selected 60 Cochrane reviews of clinical interventions and repeated literature searches using 14 abbreviated approaches (combinations of MEDLINE, Embase, CENTRAL with and without s...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,meta分析


    authors: Nussbaumer-Streit B,Klerings I,Wagner G,Heise TL,Dobrescu AI,Armijo-Olivo S,Stratil JM,Persad E,Lhachimi SK,Van Noord MG,Mittermayr T,Zeeb H,Hemkens L,Gartlehner G

    更新日期:2018-10-01 00:00:00

  • Estimating risk difference from relative association measures in meta-analysis can infrequently pose interpretational challenges.

    abstract:OBJECTIVE:Risk difference (RD) is often estimated from relative association measures generated by meta-analysis and a particular group's baseline risk. We describe a problematic situation in using this approach. STUDY DESIGN AND SETTING:We encountered a meta-analysis in which a confidence interval (CI) of relative ris...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Murad MH,Montori VM,Walter SD,Guyatt GH

    更新日期:2009-08-01 00:00:00

  • Diagnostic interval and mortality in colorectal cancer: U-shaped association demonstrated for three different datasets.

    abstract:OBJECTIVE:To test the theory of a U-shaped association between time from the first presentation of symptoms in primary care to the diagnosis (the diagnostic interval) and mortality after diagnosis of colorectal cancer (CRC). STUDY DESIGN AND SETTING:Three population-based studies in Denmark and the United Kingdom usin...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Tørring ML,Frydenberg M,Hamilton W,Hansen RP,Lautrup MD,Vedsted P

    更新日期:2012-06-01 00:00:00

  • Inferential reproduction analysis demonstrated that "paracetamol for acute low back pain" trial conclusions were reproducible.

    abstract:OBJECTIVES:The aim of this study was to reanalyze and reinterpret data obtained in Paracetamol in Acute Low Back Pain (PACE), the first large randomized controlled trial evaluating the efficacy of paracetamol in acute low back pain, to assess the inferential reproducibility of the original conclusions. STUDY DESIGN AN...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Schreijenberg M,Chiarotto A,Mauff KAL,Lin CC,Maher CG,Koes BW

    更新日期:2020-05-01 00:00:00

  • Different methods to assess quality of life from multiple follow-ups in a longitudinal asthma study.

    abstract:BACKGROUND AND OBJECTIVE:Serial measurements obtained during observational longitudinal studies offer the opportunity to describe the effects of chronic diseases on patient-centered outcomes such as quality of life. The purpose of this study was to assess serial Asthma Quality of Life Questionnaire (AQLQ) and SF-36 sco...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Mancuso CA,Peterson MG

    更新日期:2004-01-01 00:00:00

  • The effect of local recurrence on survival time in adult high-grade soft tissue sarcomas.

    abstract::Data gathered on 262 adults with high-grade soft tissue sarcoma, operated on at the same institution for curative intent, were used to study formally, and to quantitate for the first time, the relationship between local recurrence of the tumor and survival time. Using Cox's proportional hazards model with a time-depen...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Emrich LJ,Ruka W,Driscoll DL,Karakousis CP

    更新日期:1989-01-01 00:00:00

  • Calculating kappas from adjusted data improved the comparability of the reliability of triage systems: a comparative study.

    abstract:OBJECTIVES:It is difficult to compare the reliability of triage systems with the kappa statistic. In this article, a method for comparing triage systems was developed and applied to previously conducted triage reliability studies. STUDY DESIGN AND SETTING:From simulations with theoretical distributions, the minimum, n...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,评审


    authors: van der Wulp I,van Stel HF

    更新日期:2010-11-01 00:00:00

  • The use of clinical information in diagnosing chronic heart failure: a comparison between general practitioners, cardiologists, and students.

    abstract::In a clinical judgement analysis study, 27 general practitioners, 22 cardiologists, and 21 medical students assessed 40 case vignettes with regard to the probability of heart failure, in order to study the weights of different kinds of information (cues) measured by the regression coefficients in a multiple regression...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Skånér Y,Bring J,Ullman B,Strender LE

    更新日期:2000-11-01 00:00:00

  • Diabetes and disability among Mexican Americans: the effect of different measures of diabetes on its association with disability.

    abstract::The association of non-insulin-dependent diabetes mellitus and disability was evaluated in a population of Mexican Americans from the southwest U.S. using data from the Hispanic Health and Nutrition Examination Survey. Among the total sample of persons who completed a clinical examination, 14.6% reported a limitation ...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Macheledt JE,Vernon SW

    更新日期:1992-05-01 00:00:00

  • An enhancement of ROC curves made them clinically relevant for diagnostic-test comparison and optimal-threshold determination.

    abstract:OBJECTIVES:The receiver operating characteristic curves (ROC curves) are often used to compare continuous diagnostic tests or determine the optimal threshold of a test; however, they do not consider the costs of misclassifications or the disease prevalence. The ROC graph was extended to allow for these aspects. STUDY ...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Subtil F,Rabilloud M

    更新日期:2015-07-01 00:00:00

  • The Marks Asthma Quality of Life Questionnaire: further validation and examination of responsiveness to change.

    abstract::We performed analyses to examine the structure, validity, and responsiveness to change of the Marks Asthma Quality of Life Questionnaire (AQLQ), originally validated in Australia in a self-administered format, among 539 U.S. subjects with asthma. Subjects were interviewed twice by telephone over an 18-month period. Ba...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Katz PP,Eisner MD,Henke J,Shiboski S,Yelin EH,Blanc PD

    更新日期:1999-07-01 00:00:00

  • Combining ecological and individual variables to reduce confounding by indication: case study--subarachnoid hemorrhage treatment.

    abstract::Ecological studies may reduce the problem of confounding by indication; however, these studies introduce new biases not present in individual-level analyses. To study the potential for ecological variables to reduce confounding by indication, we used a large database of admissions for ruptured cerebral aneurysms to ev...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,多中心研究


    authors: Johnston SC

    更新日期:2000-12-01 00:00:00

  • Designing pragmatic trials-what can we learn from lessons learned?

    abstract::Pragmatic trials aim to inform clinical decision making by measuring the effect of a treatment in clinical practice. The purpose of the PRECIS-2 tool is to support in designing a truly pragmatic trial. We comment on a study by Forbes et al., who assessed the applicability of the PRECIS-2 tool. The tool will prove part...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Groenwold RHH,Dekkers OM

    更新日期:2017-10-01 00:00:00

  • Multiple performance measures are needed to evaluate triage systems in the emergency department.

    abstract:OBJECTIVES:Emergency department triage systems can be considered prediction rules with an ordinal outcome, where different directions of misclassification have different clinical consequences. We evaluated strategies to compare the performance of triage systems and aimed to propose a set of performance measures that sh...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Zachariasse JM,Nieboer D,Oostenbrink R,Moll HA,Steyerberg EW

    更新日期:2018-02-01 00:00:00

  • The evolving clinical status of patients after a myocardial infarction: the importance of post-hospital data for mortality prediction.

    abstract::Studies predicting mortality after myocardial infarction (MI) usually rely on in-hospital data, and combine patients admitted for the first MI with recurrent MI patients. Since treatment decisions are often made or modified at the first outpatient clinic visit, this study was designed to evaluate the importance of pos...

    journal_title:Journal of clinical epidemiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Elmore JG,Viscoli CM,Horwitz RI

    更新日期:1996-11-01 00:00:00

  • Effects on blood pressure of a decrease in sodium use in institutional food preparation: the Exeter-Andover Project.

    abstract::To judge the effect on blood pressure, sodium intake of students at two boarding high schools was reduced by 15-20% through changes in food purchasing and in preparation practices in the schools' kitchens. Students were not asked to change their usual eating habits. Each school served alternately as the control or int...

    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章


    authors: Ellison RC,Capper AL,Stephenson WP,Goldberg RJ,Hosmer DW Jr,Humphrey KF,Ockene JK,Gamble WJ,Witschi JC,Stare FJ

    更新日期:1989-01-01 00:00:00