A cohort study found that white blood cell count and endocrine markers predicted preterm birth in symptomatic women.

Abstract:

OBJECTIVE:This cohort study investigated potential clinical and biochemical predictors of subsequent preterm birth in women presenting with threatened preterm labor. STUDY DESIGN AND SETTING:Subjects were 218 pregnant women admitted to hospital with a diagnosis of threatened preterm labor at 22-36 weeks gestation. Exclusion criteria were multiple pregnancy, fetal anomalies, diabetes mellitus, abruptio placenta, preeclampsia, intrauterine growth restriction, cervical dilatation > 4 cm, and clinical signs of infection. Analyses used logistic regression. RESULTS:The presence of ruptured membranes was the best predictor of birth within 48 hours. Other important predictors were maternal white blood cell count at 22-27 weeks gestation and maternal adrenocorticotropin and corticotropin-releasing hormone concentrations at 28-36 weeks gestation. CONCLUSION:Subclinical infection may be an important etiologic factor in preterm births of gestational age < 28 weeks. For those at > or = 28 weeks gestation, the findings support the etiologic role of activation of the fetal and/or maternal hypothalamic pituitary adrenal axis leading to preterm birth.

journal_name

J Clin Epidemiol

authors

Campbell MK,Challis JR,DaSilva O,Bocking AD

doi

10.1016/j.jclinepi.2004.06.015

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

304-10

issue

3

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(04)00274-4

journal_volume

58

pub_type

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