Use of global assessment measures in dementia drug trials.

Abstract:

:I argue in this paper that the use of a global clinical impression of change as a primary measure in dementia drug trials is appropriate, given that we do not yet understand clearly enough what Alzheimer's disease looks like as it gets better.

journal_name

J Clin Epidemiol

authors

Rockwood K

doi

10.1016/0895-4356(94)90039-6

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

101-3

issue

1

eissn

0895-4356

issn

1878-5921

pii

0895-4356(94)90039-6

journal_volume

47

pub_type

杂志文章
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    authors: McDuffie HH

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  • A prospective study of factors affecting age at menopause.

    abstract::This paper describes a multivariate analysis of a 3-year prospective study of the covariates of age at menopause among women who were randomly sampled from a general population. This approach avoids three problems that may account for the inconsistent results of prior studies: recall bias in retrospectively collected ...

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    doi:10.1016/0895-4356(89)90044-9

    authors: Brambilla DJ,McKinlay SM

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  • External validation of prognostic models for critically ill patients required substantial sample sizes.

    abstract:OBJECTIVE:To investigate the behavior of predictive performance measures that are commonly used in external validation of prognostic models for outcome at intensive care units (ICUs). STUDY DESIGN AND SETTING:Four prognostic models (Simplified Acute Physiology Score II, the Acute Physiology and Chronic Health Evaluati...

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    doi:10.1016/j.jclinepi.2006.08.011

    authors: Peek N,Arts DG,Bosman RJ,van der Voort PH,de Keizer NF

    更新日期:2007-05-01 00:00:00

  • The true treatment benefit is unpredictable in clinical trials using surrogate outcome measured with diagnostic tests.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.jclinepi.2005.02.024

    authors: Kassaï B,Shah NR,Leizorovicza A,Cucherat M,Gueyffier F,Boissel JP

    更新日期:2005-10-01 00:00:00

  • Getting more out of meta-analyses: a new approach to meta-analysis in light of unexplained heterogeneity.

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    authors: Saad A,Yekutieli D,Lev-Ran S,Gross R,Guyatt G

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  • International classification of diseases codes showed modest sensitivity for detecting community-acquired pneumonia.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章

    doi:10.1016/j.jclinepi.2006.10.018

    authors: van de Garde EM,Oosterheert JJ,Bonten M,Kaplan RC,Leufkens HG

    更新日期:2007-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1998-03-01 00:00:00

  • Parents were accurate proxy reporters of urgent pediatric asthma health services: a retrospective agreement analysis.

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    pub_type: 杂志文章

    doi:10.1016/j.jclinepi.2007.02.002

    authors: Ungar WJ,Davidson-Grimwood SR,Cousins M

    更新日期:2007-11-01 00:00:00

  • Socioeconomic and demographic factors that predict where children receive cancer care in Florida.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章

    doi:10.1016/0895-4356(93)90126-l

    authors: Roush SW,Krischer JP,Cox MW,Pollock BH

    更新日期:1993-06-01 00:00:00

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    doi:10.1016/j.jclinepi.2018.02.008

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    更新日期:1988-01-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.jclinepi.2012.06.024

    authors: Geere JH,Geere JA,Hunter PR

    更新日期:2013-03-01 00:00:00

  • Testing the equivalence of translations of widely used response choice labels: results from the IQOLA Project. International Quality of Life Assessment.

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    pub_type: 杂志文章

    doi:10.1016/s0895-4356(98)00084-5

    authors: Keller SD,Ware JE Jr,Gandek B,Aaronson NK,Alonso J,Apolone G,Bjorner JB,Brazier J,Bullinger M,Fukuhara S,Kaasa S,Leplège A,Sanson-Fisher RW,Sullivan M,Wood-Dauphinee S

    更新日期:1998-11-01 00:00:00

  • Clinical correlates of advanced retinopathy in type II diabetic patients: implications for screening. The CODIAB-INSERM-Zeneca Pharma Study Group.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/0895-4356(95)00582-x

    authors: Delcourt C,Villatte-Cathelineau B,Vauzelle-Kervroedan F,Papoz L

    更新日期:1996-06-01 00:00:00

  • Quality of life and functional health of primary care patients.

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    pub_type: 杂志文章

    doi:10.1016/0895-4356(92)90171-i

    authors: Parkerson GR Jr,Broadhead WE,Tse CK

    更新日期:1992-11-01 00:00:00

  • Increasing physicians' awareness of the impact of statistics on research outcomes: comparative power of the t-test and and Wilcoxon Rank-Sum test in small samples applied research.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章

    doi:10.1016/s0895-4356(98)00168-1

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    更新日期:1999-03-01 00:00:00

  • Evidence of survival benefit was often ambiguous in randomized trials of cancer treatments.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章

    doi:10.1016/j.jclinepi.2020.06.026

    authors: Perneger TV,Brindel P,Combescure C,Gayet-Ageron A

    更新日期:2020-11-01 00:00:00

  • Comparison of the statistical efficiency of case-crossover and case-control designs: application to severe cutaneous adverse reactions.

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    journal_title:Journal of clinical epidemiology

    pub_type: 杂志文章

    doi:10.1016/s0895-4356(01)00404-8

    authors: Viboud C,Boëlle PY,Kelly J,Auquier A,Schlingmann J,Roujeau JC,Flahault A

    更新日期:2001-12-01 00:00:00

  • Systematic review identifies number of strategies important for retaining study participants.

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章,meta分析

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  • Optimal sampling in derivation studies was associated with improved discrimination in external validation for heart failure prognostic models.

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    pub_type: 杂志文章

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    更新日期:2018-12-01 00:00:00

  • Comparison of "Rose Questionnaire Angina" to exercise thallium scintigraphy: different findings in males and females.

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  • Health status measurement in Toxic Oil Syndrome.

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    authors: Waxman R,Woodburn H,Powell M,Woodburn J,Blackburn S,Helliwell P

    更新日期:2003-11-01 00:00:00