The next stage: molecular epidemiology.

Abstract:

:The traditional approach in epidemiology of relating exposure to an environmental agent such as a drug or infective agent has been to measure an overall risk (i.e., average and then "adjust risk for demographic variables and other confounders"). An attempt is sometimes made to define a "susceptible" subgroup. The analyses are usually based on good statistical methodology rather than an understanding of the interaction of body of host and agent. A twofold risk for 1000 exposed versus nonexposed people could be an average twofold risk for all 1000 exposed or a 20-fold risk for 100 exposed individuals (i.e., a drug-host interaction). Clearly, finding the 100 individuals with a 20-fold risk has much greater clinical importance than a twofold risk for 1000 people. The world of epidemiology may be changing-we may soon be able to define risk based on genetic susceptibility, at least sometimes.

journal_name

J Clin Epidemiol

authors

Shpilberg O,Dorman JS,Ferrell RE,Trucco M,Shahar A,Kuller LH

doi

10.1016/s0895-4356(97)00052-8

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

633-8

issue

6

eissn

0895-4356

issn

1878-5921

pii

S0895-4356(97)00052-8

journal_volume

50

pub_type

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