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Appearance of thymosin alpha 1 in supernatants of monocytes incubated with prothymosin alpha.

Abstract：

:Prothymosin alpha, a polypeptide of 109 to 111 amino acid residues, contains the entire thymosin alpha 1 sequence (residues 1-28) at its amino terminal. Human peripheral blood monocytes incubated with prothymosin alpha release thymosin alpha 1 in the culture supernatants. In addition total RNA is found to increase. The production of thymosin alpha 1 involves de novo protein synthesis as shown by the kinetics of this release and its inhibition by actinomycin D and cycloheximide. Thymosin alpha 1 release, possibly in association with HLA-DR, stimulates the proliferation of the T cell population.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Frillingos S,Seferiadis K,Papanastasiou M,Baxevanis CN,Frangou-Lazaridis M,Economou M,Papamichail M,Tsolas O

doi

10.1016/0003-9861(92)90570-m

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

256-63

issue

1

eissn

0003-9861

issn

1096-0384

pii

0003-9861(92)90570-M

journal_volume

296

pub_type

杂志文章

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