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Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation.

Abstract：

:Role of c-Src in muscle differentiation has been controversial. Here, we investigated if c-Src positively or negatively regulates muscle differentiation, using H9c2 and C2C12 cell lines. Inhibition of c-Src by treatment with PP1 and SU6656, pharmacologic inhibitors of Src family kinases, or by expression of a dominant negative c-Src, all induced muscle differentiation in proliferation medium (PM). In differentiating cells in differentiation medium (DM), c-Src activity gradually decreased and reached basal level 3 days after induction of differentiation. Inhibition of c-Src suppressed Raf/MEK/ERK pathway but activated p38 MAPK. Inhibition of p38 MAPK did not affect c-Src activity in PM. However, it reactivated Raf/MEK/ERK pathway in c-Src-inhibited cells regardless of PM or DM. Concomitant inhibition of c-Src and p38 MAPK activities blocked muscle differentiation in both media. In conclusion, suppression of c-Src activity stimulates muscle differentiation by activating p38 MAPK uni-directionally.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Lim MJ,Seo YH,Choi KJ,Cho CH,Kim BS,Kim YH,Lee J,Lee H,Jung CY,Ha J,Kang I,Kim SS

doi

10.1016/j.abb.2007.06.004

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

197-208

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(07)00291-3

journal_volume

465

pub_type

杂志文章

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