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Lycopene: modes of action to promote prostate health.

Abstract：

:Epidemiological evidence strongly suggests that lycopene consumption contributes to prostate cancer risk reduction. Preclinical studies show that lycopene acts via different mechanisms, which have the potential to cooperate in reducing the proliferation of normal and cancerous prostate epithelial cells, in reducing DNA damage, and in improving oxidative stress defense. The mechanisms include inhibition of prostatic IGF-I signaling, IL-6 expression, and androgen signaling. Moreover, lycopene improves gap-junctional communication and induces phase II drug metabolizing enzymes as well as oxidative defense genes. These findings provide plausible explanations for the epidemiological findings how lycopene can contribute to reduced prostate cancer risk. The novel finding that lycopene reduces local androgen signaling in the prostate suggests also efficacy in prevention of benign prostate hyperplasia. Intervention trials in humans are required to finally prove clinical efficacy of the lycopene molecule in prostate health.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Wertz K,Siler U,Goralczyk R

doi

10.1016/j.abb.2004.04.023

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

127-34

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003986104002620

journal_volume

430

pub_type

杂志文章,评审

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