MicroRNA-342 targets Cofilin 1 to suppress the growth, migration and invasion of human breast cancer cells.

abstract：:Oxidants produced by neutrophils have been implicated in causing cancers associated with chronic inflammation. Hypochlorous acid is the most potent oxidant produced by these cells in appreciable amounts. It reacts with amines to form chloramines, which are weaker oxidants but are mutagenic. Recently, we showed that su...

journal_title：Archives of biochemistry and biophysics

authors： Vile GF,Rothwell LA,Kettle AJ

更新日期：2000-05-01 00:00:00

abstract：:The gene of the human fatty acid omega-hydroxylase, CYP4A11, has been isolated from a human BAC library, and its complete genomic sequence has been determined. The CYP4A11 gene spanned 12,568 bp and contained 12 exons. The known PPAR recognition elements (PPRE), which were reported to be involved in the induction of C...

journal_title：Archives of biochemistry and biophysics

authors： Kawashima H,Naganuma T,Kusunose E,Kono T,Yasumoto R,Sugimura K,Kishimoto T

更新日期：2000-06-15 00:00:00

abstract：:Organic acidurias (OADs) are inherited disorders of amino acid metabolism biochemically characterized by accumulation of short-chain carboxylic acids in tissues and biological fluids of the affected patients and clinically by predominant neurological manifestations. Some of these disorders are amenable to treatment, w...

journal_title：Archives of biochemistry and biophysics

authors： Wajner M,Vargas CR,Amaral AU

更新日期：2020-12-15 00:00:00

abstract：:Isolated mitochondria loaded with Ca(2+) and then exposed to Fe(2+) show a transient release of Ca(2+). The magnitude of this response depends on the Ca(2+) loading and the kinetics of the response depends on the concentration of added Fe(2+). We investigated the Fe(2+)-induced Ca(2+) release mechanism by measuring mi...

journal_title：Archives of biochemistry and biophysics

authors： Gogvadze V,Walter PB,Ames BN

更新日期：2002-02-15 00:00:00

abstract：:A microsomal retinol dehydrogenase (RoDH) that recognizes holo-cellular retinol binding protein (CRBP) as substrate is inhibited by phenylarsine oxide (IC50 = 3 microM) in the presence of 10 mM cysteine. Inhibition was reversible with dithiothreitol, indicating that two cysteine residues in close proximity are essenti...

journal_title：Archives of biochemistry and biophysics

authors： Boerman MH,Napoli JL

更新日期：1995-08-20 00:00:00

abstract：:Hypertrophic scars are dermal fibrosis diseases that protrude from the surface of the skin and irregularly extend to the periphery, seriously affecting the appearance and limb function of the patient. In this study, we found that microRNA-130a (miR-130a) was increased in hypertrophic scar tissues and derived primary f...

journal_title：Archives of biochemistry and biophysics

authors： Zhang J,Zhou Q,Wang H,Huang M,Shi J,Han F,Cai W,Li Y,He T,Hu D

更新日期：2019-08-15 00:00:00

abstract：:A set of membrane proteins from murine myelomonocytic leukemia cell line WEHI-3BD+ was found to be ADP-ribosylated. Both this ADP-ribosylation reaction and granulocytic differentiation in response to recombinant G-CSF were inhibited approximately 50% by 2 mM benzamide, suggesting a correlation between these two proces...

journal_title：Archives of biochemistry and biophysics

authors： Hanson K,Aboul-Ela N,Jacobson MK,Wu MC

更新日期：1993-04-01 00:00:00

abstract：:By exploiting its capacity for binding to DNA, the protease inhibitor alpha 1-antichymotrypsin has been isolated from human serum by ammonium sulfate fractionation and successive chromatography on QAE-Sephadex, DNA-cellulose, and Sephacryl S-300. This experimental procedure compares favorably with existing methods for...

journal_title：Archives of biochemistry and biophysics

authors： Abdullah M,Siddiqui AA,Hill JA,Davies RJ

更新日期：1983-08-01 00:00:00

abstract：:Numerous conditions induce expression of manganese-containing superoxide dismutase (MnSOD) in mammalian cells. The reported inducers of MnSOD are all agents that activate two transcription factors, AP-1 and NF kappa B, but several reports have suggested that MnSOD induction relies solely on NF kappa B. We investigated...

journal_title：Archives of biochemistry and biophysics

authors： Borrello S,Demple B

更新日期：1997-12-15 00:00:00

abstract：:Addition of ascorbate or its generation from gulonolactone causes the oxidation of protein thiols and a simultaneous dehydroascorbate formation in rat liver microsomes. The participation of vitamin E in the phenomenon was studied. We measured ascorbate and protein thiol oxidation and lipid peroxidation in vitamin E de...

journal_title：Archives of biochemistry and biophysics

authors： Csala M,Szarka A,Margittai E,Mile V,Kardon T,Braun L,Mandl J,Bánhegyi G

更新日期：2001-04-01 00:00:00

abstract：:Yeast (Saccharomyces cerevisiae) alcohol dehydrogenase I (SceADH) binds NAD+ and NADH less tightly and turns over substrates more rapidly than does horse (Equus caballus) liver alcohol dehydrogenase E isoenzyme (EcaADH), and neither enzyme uses NADP efficiently. Amino acid residues in the proposed adenylate binding po...

journal_title：Archives of biochemistry and biophysics

authors： Fan F,Plapp BV

更新日期：1999-07-15 00:00:00

abstract：:Electron spin resonance (ESR) spectroscopy has been employed to examine the role of tetraperoxochromate (V) ions (CrO3-8) and other Cr(V) species in the generation of hydroxyl (OH) radicals in the reaction of Cr(VI) with H2O2 in biological media. In contrast to earlier suggestions, the present ESR studies using crysta...

journal_title：Archives of biochemistry and biophysics

authors： Shi XL,Dalal NS

更新日期：1990-08-15 00:00:00

abstract：:Cytochrome P450 (P450) 2C1/2 contains redundant endoplasmic reticulum (ER) retention signals and is excluded from the recycling pathway. Other P450s, such as P450 2E1, have been detected in the plasma membrane and Golgi apparatus. To examine whether the mechanisms of ER retention might differ for P450 2C1/2 and P450 2...

journal_title：Archives of biochemistry and biophysics

authors： Szczesna-Skorupa E,Chen CD,Kemper B

更新日期：2000-02-15 00:00:00

abstract：:Fibronectin heterogeneity is, in part, the result of post-translational modifications. In these experiments, cartilage fibronectins were purified by anion exchange chromatography, followed by gelatin affinity chromatography or immunoprecipitation, and, finally, sodium dodecyl sulfate--polyacrylamide gel electrophoresi...

journal_title：Archives of biochemistry and biophysics

authors： Burton-Wurster N,Lust G

更新日期：1993-11-01 00:00:00

abstract：:Sequence analyses of the C-terminal membrane intercalative region of the rat cytochrome b(5) indicated that this domain has, in addition to a signal sequence, a combined element of the classic stop-transfer sequence typically found in a variety of transmembrane proteins. Such bitopic protein arrangements arise by tand...

journal_title：Archives of biochemistry and biophysics

authors： Kaderbhai MA,Morgan R,Kaderbhai NN

更新日期：2003-04-15 00:00:00

abstract：:The soluble enzymatic luminescent system of the dinoflagellate Pyrocystis lunula (luciferase-luciferin) is coupled with an enzymatic NAD(P)H-dependent reaction. The enzyme is a soluble reductase (Mr 47,000) which catalyzes, in the presence of NAD(P)H, the reduction of a molecule called P630. Reduced P630 has the same ...

journal_title：Archives of biochemistry and biophysics

authors： Fresneau C,Hill M,Lescure N,Arrio B,Dupaix A,Volfin P

更新日期：1986-12-01 00:00:00

abstract：:We have characterized tamulustoxin, a novel 35-amino-acid peptide found in the venom of the Indian red scorpion (Mesobuthus tamulus). Tamulustoxin was identified through a [125I]toxin I screen, designed to identify toxins that block voltage-activated potassium channels. Tamulustoxin has also been cloned by RT-PCR, usi...

journal_title：Archives of biochemistry and biophysics

authors： Strong PN,Clark GS,Armugam A,De-Allie FA,Joseph JS,Yemul V,Deshpande JM,Kamat R,Gadre SV,Gopalakrishnakone P,Kini RM,Owen DG,Jeyaseelan K

更新日期：2001-01-01 00:00:00

abstract：:Phenylalanine ammonia-lyase forms trans-cinnamate from L-phenylalanine, and thus stands at a gateway to secondary metabolism in higher plants. L-alpha-Amino-oxy-beta-phenylpropanoic acid (L-AOPP), a very effective competitive inhibitor of this enzyme, is most probably a transition-state analog for the elimination reac...

journal_title：Archives of biochemistry and biophysics

authors： Jones DH,Northcote DH

更新日期：1984-11-15 00:00:00

abstract：:Although mutation of mitochondrial DNA (mtDNA) in human tissues has been established to associate with intrinsic aging, the impact of environmental factors on the formation and accumulation of mtDNA mutations and oxidative DNA damage in human tissues is poorly understood. We have investigated the levels of mtDNA with ...

journal_title：Archives of biochemistry and biophysics

authors： Lee HC,Lim ML,Lu CY,Liu VW,Fahn HJ,Zhang C,Nagley P,Wei YH

更新日期：1999-02-15 00:00:00

abstract：:Geranylgeranyl diphosphate synthase supplies the essential acyclic precursor for Taxol biosynthesis in methyl jasmonate-induced Taxus canadensis suspension cell cultures. A cDNA encoding this prenyltransferase was cloned from an induced T. canadensis cell library. The recombinant enzyme expressed in yeast was confirme...

journal_title：Archives of biochemistry and biophysics

authors： Hefner J,Ketchum RE,Croteau R

更新日期：1998-12-01 00:00:00

abstract：:Systemic inflammatory response syndrome (SIRS) is associated with excessive inflammatory response, however, the pathophysiology of inflammation is poorly understood. The retinoid-related orphan receptor α (RORα) is a key inflammatory regulator, but the mechanisms underlying its role remain unclear. The aim of this stu...

journal_title：Archives of biochemistry and biophysics

authors： Han S,Li Z,Han F,Jia Y,Qi L,Wu G,Cai W,Xu Y,Li C,Zhang W,Hu D

更新日期：2019-06-15 00:00:00

abstract：:Coenzyme Q (Q) is a redox active lipid that is an essential component of the electron transport chain. Here, we show that steady state levels of Coq3, Coq4, Coq6, Coq7 and Coq9 polypeptides in yeast mitochondria are dependent on the expression of each of the other COQ genes. Submitochondrial localization studies indic...

journal_title：Archives of biochemistry and biophysics

authors： Hsieh EJ,Gin P,Gulmezian M,Tran UC,Saiki R,Marbois BN,Clarke CF

更新日期：2007-07-01 00:00:00

abstract：:Microsomal P450s catalyze the monooxygenation of a large variety of hydrophobic compounds, including drugs, steroids, carcinogens, and fatty acids. The interaction of microsomal P450s with their electron transfer partner, NADPH-P450 reductase, during the transfer of electrons from NADPH to P450, for oxygen activation,...

journal_title：Archives of biochemistry and biophysics

authors： Peterson JA,Boddupalli SS

更新日期：1992-05-01 00:00:00

abstract：:cDNA for mouse cytochrome c oxidase subunit IV (COXIV) was isolated by screening mouse liver and kidney cDNA libraries with a bovine COXIV cDNA probe. The 679-nucleotide nearly full length cDNA codes for a 22-amino acid presequence and a 147-amino acid mature protein which show 77 to 95% positional identity with the p...

journal_title：Archives of biochemistry and biophysics

authors： Carter RS,Avadhani NG

更新日期：1991-07-01 00:00:00

abstract：:Heme and iron are essential to almost all forms of life. The strict maintenance of heme and iron homeostasis is essential to prevent cellular toxicity and the existence of systemic and intracellular regulation is fundamental. Cytosolic heme can be catabolized and detoxified by heme oxygenases (HOs). Interestingly, fre...

journal_title：Archives of biochemistry and biophysics

authors： Yanatori I,Richardson DR,Toyokuni S,Kishi F

更新日期：2019-09-15 00:00:00

abstract：:The role of 1,25(OH)(2)D(3) on the intestinal NCX activity was studied in vitamin D-deficient chicks (-D) as well as the hormone effect on NCX1 protein and gene expression and the potential molecular mechanisms underlying the responses. Normal, -D and -D chicks treated with cholecalciferol or 1,25(OH)(2)D(3) were empl...

journal_title：Archives of biochemistry and biophysics

authors： Centeno V,Picotto G,Pérez A,Alisio A,Tolosa de Talamoni N

更新日期：2011-05-15 00:00:00

abstract：:Ovalbumin extracted from oviduct slices incubated with [35S]methionine or [2-3]mannose contained two biosynthetic intermediates, OE and OF (Y. Kato, H. Iwase, and K. Hotta, 1984, J. Biochem. (Tokyo) 95, 455-463). In the present study, these intermediates are further characterized. The 3H dpm/35S dpm ratio of OF labele...

journal_title：Archives of biochemistry and biophysics

authors： Kato Y,Iwase H,Hotta K

更新日期：1986-02-01 00:00:00

abstract：:Podocytes and their foot processes interlinked by slit diaphragms, constitute a continuous outermost layer of the glomerular capillary and seem to be crucial for maintaining the integrity of the glomerular filtration barrier. Purinergic signaling is involved in a wide range of physiological processes in the renal syst...

journal_title：Archives of biochemistry and biophysics

authors： Szrejder M,Rachubik P,Rogacka D,Audzeyenka I,Rychłowski M,Angielski S,Piwkowska A

更新日期：2020-11-30 00:00:00

abstract：:Bovine liver glutamate dehydrogenase reacts covalently with 2-(4-bromo-2,3-dioxobutylthio)adenosine 5'-monophosphate (2-BDB-TAMP) with incorporation of 1 mol reagent/mol enzyme subunit and loss of one of the two ADP sites of native enzyme [S. P. Batra and R. F. Colman, J. Biol. Chem. 261, 15565-15571 (1986)]. Incorpor...

journal_title：Archives of biochemistry and biophysics

authors： Batra SP,Lark RH,Colman RF

更新日期：1989-04-01 00:00:00

abstract：:Dihydrocaffeic acid, a dietary constituent and a microbial metabolite of flavonoids, is an antioxidant, but few biological effects have been examined. After its production by microflora in the colon, dihydrocaffeic acid is absorbed and found in plasma as a combination of free and metabolized forms. Excess solar UV rad...

journal_title：Archives of biochemistry and biophysics

authors： Poquet L,Clifford MN,Williamson G

更新日期：2008-08-15 00:00:00