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Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion Mesobuthus tamulus.

Abstract：

:We have characterized tamulustoxin, a novel 35-amino-acid peptide found in the venom of the Indian red scorpion (Mesobuthus tamulus). Tamulustoxin was identified through a [125I]toxin I screen, designed to identify toxins that block voltage-activated potassium channels. Tamulustoxin has also been cloned by RT-PCR, using RNA extracted from scorpion venom glands. Tamulustoxin shares no homology with other scorpion venom toxins, although the positions of its six cysteine residues would suggest that it shares the same structural scaffold. Tamulustoxin rapidly inhibited both peak and steady-state currents (18.9 +/- 1.0 and 37 +/- 1.1%, respectively) produced by injecting CHO cells with mRNA encoding the hKv1.6 channel.

journal_name

Arch Biochem Biophys

journal_title

Archives of biochemistry and biophysics

authors

Strong PN,Clark GS,Armugam A,De-Allie FA,Joseph JS,Yemul V,Deshpande JM,Kamat R,Gadre SV,Gopalakrishnakone P,Kini RM,Owen DG,Jeyaseelan K

doi

10.1006/abbi.2000.2135

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

138-44

issue

1

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(00)92135-0

journal_volume

385

pub_type

杂志文章

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