Identification and characterization of protein kinase C-related enzymes in frog retina.

Abstract:

:We isolated two types of protein kinase C-related enzymes (fPKC) in frog (Rana catesbeiana) retina. Three sequential steps of column chromatography of DEAE-cellulose, butyl-Toyopearl, and hydroxylapatite were carried out and resulted in the separation of two types of distinct Ca2+/phospholipid-dependent protein kinase activities. These proteins reacted with antibodies raised against synthetic peptides based on the predicted amino acid sequences of rat protein kinase C delta or zeta subspecies, and showed molecular masses of 90 and 75 kDa on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, respectively. Immunocytochemical analysis of 90 and 75K fPKC in frog retina revealed that the 75K fPKC was localized in the outer segment of cone cells and in the microvillar projections of Müller cells. These results suggested that fPKCs play differential roles on the photosignal transduction in frog retina.

journal_name

Arch Biochem Biophys

authors

Terasawa M,Hagiwara M,Hachiya T,Kobayashi R,Obata S,Wakabayashi T,Hidaka H

doi

10.1016/0003-9861(91)90409-c

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

213-7

issue

2

eissn

0003-9861

issn

1096-0384

pii

0003-9861(91)90409-C

journal_volume

287

pub_type

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