Reductive metabolism of N-nitrosodiphenylamine to the corresponding hydrazine derivative.

Abstract:

:The first evidence for the reductive metabolism of a noncyclic nitrosamine to the corresponding hydrazine derivative in vivo and in vitro is provided. Under anaerobic conditions, N-nitrosodiphenylamine was reduced by guinea pig liver 9000g supernatant to 1,1-diphenylhydrazine in the presence of 2-hydroxypyrimidine or to acetaldehyde diphenylhydrazone in the presence of acetaldehyde. These metabolites were identified unequivocally by comparative study with authentic samples. In addition, the study shows that such reductive reactions of the nitrosamine can be catalyzed by guinea pig and rabbit liver aldehyde oxidase in the presence of its electron donors. When the nitrosamine was given orally to acetaldehyde-treated guinea pigs, a metabolite was detected from plasma and identified as acetaldehyde diphenylhydrazone by comparison with the authentic sample.

journal_name

Arch Biochem Biophys

authors

Tatsumi K,Yamada H,Kitamura S

doi

10.1016/0003-9861(83)90282-5

subject

Has Abstract

pub_date

1983-10-01 00:00:00

pages

174-81

issue

1

eissn

0003-9861

issn

1096-0384

pii

0003-9861(83)90282-5

journal_volume

226

pub_type

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