A randomized placebo-controlled study on the effects of lutein and zeaxanthin on visual processing speed in young healthy subjects.

Abstract:

:Speed of processing is a particularly important characteristic of the visual system. Often a behavioral reaction to a visual stimulus must be faster than the conscious perception of that stimulus, as is the case with many sports (e.g., baseball). Visual psychophysics provides a relatively simple and precise means of measuring visual processing speed called the temporal contrast sensitivity function (tCSF). Past study has shown that macular pigment (a collection of xanthophylls, lutein (L), meso-zeaxanthin (MZ) and zeaxanthin (Z), found in the retina) optical density (MPOD) is positively correlated with the tCSF. In this study, we found similar correlations when testing 102 young healthy subjects. As a follow-up, we randomized 69 subjects to receive a placebo (n=15) or one of two L and Z supplements (n=54). MPOD and tCSF were measured psychophysically at baseline and 4months. Neither MPOD nor tCSF changed for the placebo condition, but both improved significantly as a result of supplementation. These results show that an intervention with L and Z can increase processing speed even in young healthy subjects.

journal_name

Arch Biochem Biophys

authors

Bovier ER,Hammond BR

doi

10.1016/j.abb.2014.11.012

subject

Has Abstract

pub_date

2015-04-15 00:00:00

pages

54-57

eissn

0003-9861

issn

1096-0384

pii

S0003-9861(14)00401-9

journal_volume

572

pub_type

杂志文章,随机对照试验
  • Molecular basis of the interaction between IGFBP-3 and retinoid X receptor: role in modulation of RAR-signaling.

    abstract::IGFBP-3 interacts with the retinoid X receptor-alpha (RXRalpha) and retinoic acid receptor-alpha (RARalpha) and thereby interferes with the formation of RXR:RAR heterodimers. Here we identify the domains in RXRalpha and IGFBP-3 that participate in this interaction. When different regions of RXRalpha were expressed ind...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2007.06.013

    authors: Schedlich LJ,Graham LD,O'Han MK,Muthukaruppan A,Yan X,Firth SM,Baxter RC

    更新日期:2007-09-15 00:00:00

  • Antithrombin in vertebrate species: conservation of the heparin-dependent anticoagulant mechanism.

    abstract::Heparin is thought to regulate the rate of mammalian blood clotting by enhancing the activity of antithrombin, an inhibitor of coagulation enzymes. The present study establishes that this same inhibitor is present in the blood plasma of each of the terrestrial vertebrate groups including mammals, birds, reptiles, and ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/0003-9861(83)90488-5

    authors: Jordan RE

    更新日期:1983-12-01 00:00:00

  • Renal excretion of 8-oxo-7,8-dihydro-2(')-deoxyguanosine: degradation rates of RNA and metabolic rate in humans.

    abstract::Renally excreted 8-oxo-7,8-dihydro-2(')-deoxyguanosine (oxo(8)dG) is a potential marker of oxidative DNA damage by reactive oxygen species. Whole-body degradation rates of t- and rRNA are potential indicators of the resting metabolic rate (RMR). Excretion rates of oxo(8)dG and degradation rates of t- and rRNA were det...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/S0003-9861(02)00034-6

    authors: Topp H,Armbrust S,Lengger C,Schöch G,Davies J,Stichler W,Manz F,Fusch C

    更新日期:2002-06-01 00:00:00

  • Inhibition of nitric oxide synthase isoforms by porphyrins.

    abstract::Protoporphyrin IX inhibits citrulline formation by all three nitric oxide synthase isoforms in a manner reversible by dilution. Zinc protoporphyrin IX, by contrast, produces a time- and concentration-dependent inactivation of all three nitric oxide synthase isoforms, not reversible by dilution. The inhibition of citru...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1996.0360

    authors: Wolff DJ,Naddelman RA,Lubeskie A,Saks DA

    更新日期:1996-09-01 00:00:00

  • Regulatory aspects of the glutamylation of methotrexate in cultured hepatoma cells.

    abstract::The glutamylation of methotrexate has been evaluated in H35 hepatoma cells in vitro as a function of the conditions of culture. Glutamylation yields methotrexate polyglutamate with two to five additional glutamate residues and is a saturable process. The rate of glutamylation increases little above 10 microM extracell...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/0003-9861(83)90337-5

    authors: Nimec Z,Galivan J

    更新日期:1983-10-15 00:00:00

  • Adhesion and clustering of charge isomers of myelin basic protein at model myelin membranes.

    abstract::The association of myelin basic protein charge isomers with the lipid part of the myelin membrane was investigated at the microscopic (molecular) level in a model membrane system, using optical waveguide lightmode spectrometry to determine with high precision the kinetics of association and dissociation to planar phos...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2003.09.020

    authors: Shanshiashvili LV,Suknidze NCh,Machaidze GG,Mikeladze DG,Ramsden JJ

    更新日期:2003-11-15 00:00:00

  • Biochemical and functional insights on the triheme cytochrome PpcA from Geobacter metallireducens.

    abstract::G. metallireducens bacterium has highly versatile respiratory pathways that provide the microorganism an enormous potential for many biotechnological applications. However, little is known about the structural and functional properties of its electron transfer components. In this work, the periplasmic cytochrome PpcA ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2018.02.017

    authors: Portela PC,Fernandes TM,Dantas JM,Ferreira MR,Salgueiro CA

    更新日期:2018-04-15 00:00:00

  • Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta.

    abstract::The cellular factor, papillomavirus (PV)-binding factor (PBF)/Huntington's disease binding protein 2 (HDBP2), was identified by its ability to bind regulatory sequences of certain papillomavirus types as well as the Huntington's disease gene. PBF is thought to be a novel nuclear-shuttling transcription factor with unk...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2007.04.017

    authors: Sichtig N,Silling S,Steger G

    更新日期:2007-08-01 00:00:00

  • Transcription factor AP-2 mRNA and DNA binding activity are constitutively expressed in SV40-immortalized but not normal human lung fibroblasts.

    abstract::Large T antigen (LT) expressed by the oncogenic DNA virus SV40 transforms cells by interacting with and perturbing the normal function of several important cellular proteins including P53, RB, c-MYC, and AP-2. AP-2 binds to regulatory elements within the SV40 enhancer and is therefore of particular interest for mechan...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1999.1142

    authors: Huang Y,Domann FE

    更新日期:1999-04-15 00:00:00

  • Dermatan is a better substrate for 4-O-sulfation than chondroitin: implications in the generation of 4-O-sulfated, L-iduronate-rich galactosaminoglycans.

    abstract::The biosynthesis of dermatan sulfate is a complex process that involves, inter alia, formation of L-iduronic acid residues by C5-epimerization of D-glucuronic acid residues already incorporated into the growing polymer. It has been shown previously that this reaction is promoted by the presence of the sulfate donor 3'...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.2000.2043

    authors: Eklund E,Rodén L,Malmström M,Malmström A

    更新日期:2000-11-15 00:00:00

  • Induction of rabbit hepatic microsomal cytochrome P-450 by imidazole: enhanced metabolic activity and altered substrate specificity.

    abstract::Pretreatment of rabbits with imidazole resulted in a twofold increase in hepatic microsomal cytochrome P-450 content, with the apparent induction of two or more distinct forms of the cytochrome [K. K. Hajek and R. F. Novak (1982) Biochem. Biophys. Res. Commun. 108, 664-672]. The metabolic properties of imidazole-induc...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/0003-9861(84)90220-0

    authors: Kaul KL,Novak RF

    更新日期:1984-12-01 00:00:00

  • Glycosylation pattern and disulfide assignments of recombinant human differentiation-stimulating factor.

    abstract::This report describes the post-translational modifications of recombinant human differentiation-stimulating factor, a 180-residue glycoprotein that is secreted from transfected Chinese hamster ovary cells. Peptide peptides containing six potential N-glycosylation sites were analyzed to determine that Asn residues 9, 3...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1993.1243

    authors: Schmelzer CH,Harris RJ,Butler D,Yedinak CM,Wagner KL,Burton LE

    更新日期:1993-05-01 00:00:00

  • Decreased cytochrome oxidase activity and changes in phospholipids in heart mitochondria from hypothyroid rats.

    abstract::The effect of hypothyroidism on kinetic characteristics of cytochrome oxidase in rat heart mitochondria was studied. Mitochondrial preparations from control and hypothyroid rats had equivalent Km values for cytochrome c, while the maximal activity of the oxidase was significantly decreased (more than 30%) in mitochond...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1993.1565

    authors: Paradies G,Ruggiero FM,Dinoi P,Petrosillo G,Quagliariello E

    更新日期:1993-11-15 00:00:00

  • Characterization of the intracellular and the plasma membrane Ca2+-ATPases in fractionated pig brain membranes using calcium pump inhibitors.

    abstract::The Ca2+-ATPase activity of isolated membranes and purified plasma membrane ATPase from pig brain was measured in the presence of specific inhibitors. The inhibition of the enzymatic activity by vanadate presents a lower affinity in microsomes than in the synaptic plasma membrane vesicles, showing K0.5 of 0.4 and 0.2 ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1997.0562

    authors: Salvador JM,Mata AM

    更新日期:1998-03-15 00:00:00

  • Inhibition of 5,10-methenyltetrahydrofolate synthetase.

    abstract::The interaction of 5-formyltetrahydrofolate analogs with murine methenyltetrahydrofolate synthetase (MTHFS) was investigated using steady-state kinetics, molecular modeling, and site-directed mutagenesis. MTHFS catalyzes the irreversible cyclization of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate. Folate ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2006.12.023

    authors: Field MS,Szebenyi DM,Perry CA,Stover PJ

    更新日期:2007-02-15 00:00:00

  • Peroxidase-catalyzed formation of quercetin quinone methide-glutathione adducts.

    abstract::The oxidation of quercetin by horseradish peroxidase/H(2)O(2) was studied in the absence but especially also in the presence of glutathione (GSH). HPLC analysis of the reaction products formed in the absence of GSH revealed formation of at least 20 different products, a result in line with other studies reporting the ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.2000.1832

    authors: Awad HM,Boersma MG,Vervoort J,Rietjens IM

    更新日期:2000-06-15 00:00:00

  • Involvement of cutaneous SR-B1 in skin lipid homeostasis.

    abstract:BACKGROUND:The main functions of the skin are to protect against environmental insults and prevent water loss, which are performed by the complex lipid- and protein matrix present in the outermost layers of the epithelium. The lipidome of these outer layers is mainly composed of ceramides, fatty acids, and cholesterol,...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2019.03.005

    authors: Muresan XM,Narzt MS,Woodby B,Ferrara F,Gruber F,Valacchi G

    更新日期:2019-05-15 00:00:00

  • Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway.

    abstract::CYP27A1, an enzyme with several important roles in cholesterol homeostasis and vitamin D₃ metabolism, has been ascribed anti-atherogenic properties. This study addresses an important problem regarding how this enzyme, involved in cholesterol metabolism in the liver and peripheral tissues, is regulated. Our results ide...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2010.11.023

    authors: Norlin M,Pettersson H,Tang W,Wikvall K

    更新日期:2011-02-15 00:00:00

  • Protein kinase C-mediated ATP stimulation of Na(+)-ATPase activity in LLC-PK1 cells involves a P2Y2 and/or P2Y4 receptor.

    abstract::ATP-activated P2Y receptors play an important role in renal sodium excretion. The aim of this study was to evaluate the modulation of ATPase-driven sodium reabsorption in the proximal tubule by ATP or adenosine (Ado). LLC-PK1 cells, a model of porcine proximal tubule cells, were used. ATP (10(-6)M) or Ado (10(-6)M) sp...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2013.03.013

    authors: Wengert M,Ribeiro MC,Abreu TP,Coutinho-Silva R,Leão-Ferreira LR,Pinheiro AA,Caruso-Neves C

    更新日期:2013-07-15 00:00:00

  • Taurine bromamine: a potent oxidant of tryptophan residues in albumin.

    abstract::Taurine is the most abundant free amino acid in leukocytes and can react with HOBr to produce taurine bromamine (Tau-NHBr). The aim of this study was to assess the ability of Tau-NHBr to oxidize tryptophan, either free or as a residue in albumin. We have demonstrated that Tau-NHBr is a powerful oxidant for tryptophan....

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2010.12.026

    authors: Ximenes VF,da Fonseca LM,de Almeida AC

    更新日期:2011-03-15 00:00:00

  • Characterization of tryptic hydrolysis of alpha-lactalbumin/saponin mixture and structural change of alpha-lactalbumin interacting with soybean saponin.

    abstract::Bovine milk alpha-lactalbumin (alpha-La) was mixed with soybean saponin, and the resulting mixture was hydrolyzed by trypsin. Saponin increased the tryptic-hydrolysis level of alpha-La only at relatively high phosphate buffer concentrations (> or = 0.05 M). T(1) experiments with acetylated soybean saponin demonstrated...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2005.01.001

    authors: Shimoyamada M,Okada Y,Watanabe K,Yamauchi R

    更新日期:2005-03-15 00:00:00

  • S-adenosyl-L-methionine:trans-caffeoyl-coenzyme A 3-O-methyltransferase from elicitor-treated parsley cell suspension cultures.

    abstract::An S-adenosyl-L-methionine:caffeoyl-CoA 3-O-methyltransferase was purified 82-fold from elicitor-induced parsley cell suspension cultures by ammonium sulfate fractionation, anionic exchange and hydrophobic interaction chromatographies, and chromatofocusing. The enzyme has an apparent pI of 5.7 and a molecular weight o...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/0003-9861(89)90299-3

    authors: Pakusch AE,Kneusel RE,Matern U

    更新日期:1989-06-01 00:00:00

  • Processing of cellulose synthase (AcsAB) from Gluconacetobacter hansenii 23769.

    abstract::The cellulose synthase protein (AcsAB) is encoded by a single gene in Gluconacetobacter hansenii ATCC 23769. We have examined the processing pattern of this enzyme and the localization of the cleavage products by heterologously expressing the truncated portions of the AcsAB protein and using specific antibodies genera...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2012.12.002

    authors: Iyer PR,Liu YA,Deng Y,McManus JB,Kao TH,Tien M

    更新日期:2013-01-15 00:00:00

  • The C-terminal region of mitochondrial glycerol-3-phosphate acyltransferase-1 interacts with the active site region and is required for activity.

    abstract::Glycerol phosphate acyltransferase (GPAT) catalyzes the formation of 1-acyl-sn-glycerol-3-phosphate from glycerol-3-phosphate and long chain fatty acyl-CoA substrates. We previously determined the topography of the mitochondrial GPAT1 isoform (mtGPAT1, 828 amino acids). mtGPAT1 has two transmembrane domains (TMDs) (aa...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2006.03.009

    authors: Pellon-Maison M,Coleman RA,Gonzalez-Baró MR

    更新日期:2006-06-15 00:00:00

  • Al(3+)-mediated changes in membrane physical properties participate in the inhibition of polyphosphoinositide hydrolysis.

    abstract::We investigated the possible involvement of Al(3+)-induced alterations in membrane physical properties in Al(3+)-mediated inhibition of polyphosphoinositide (PPI) hydrolysis by the enzyme phosphatidylinositol-specific phospholipase C (PI-PLC). Liposomes composed of brain phosphatidylcholine (PC) or of PC and a mixture...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/s0003-9861(02)00557-x

    authors: Verstraeten SV,Oteiza PI

    更新日期:2002-12-15 00:00:00

  • Minoxidil stimulates elastin expression in aortic smooth muscle cells.

    abstract::Minoxidil was found to inhibit the proliferation of smooth muscle cells in the proliferating phase, but not in the quiescent phase. Treatment of proliferating or quiescent cells with minoxidil resulted in a dose- and time-dependent stimulation of elastin synthesis specifically. Maximum stimulation (fourfold) occurred ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1006/abbi.1994.1482

    authors: Hayashi A,Suzuki T,Wachi H,Tajima S,Nishikawa T,Murad S,Pinnell SR

    更新日期:1994-11-15 00:00:00

  • A novel Arnt-interacting protein Ainp2 enhances the aryl hydrocarbon receptor signalling.

    abstract::In an effort to better understand the Ah receptor nuclear translocator (Arnt)-dependent signaling mechanisms, we employed a phage display system to identify Arnt-interacting peptides. Human liver cDNA library was utilized to screen for Arnt-interacting peptides using an Arnt construct fused to thioredoxin (TH-ArntCDel...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2005.06.026

    authors: Li Y,Luu TC,Chan Wk

    更新日期:2005-09-01 00:00:00

  • Fluorescence study of ligand binding to potato tuber pyrophosphate-dependent phosphofructokinase: evidence for competitive binding between fructose-1,6-bisphosphate and fructose-2,6-bisphosphate.

    abstract::The intrinsic fluorescence of potato tuber pyrophosphate:fructose-6-phosphate 1-phosphotransferase (PFP) was used as an indicator of conformational changes due to ligand binding. Binding of the substrates and the allosteric activator fructose-2,6-bisphosphate was quantitatively compared to their respective kinetic eff...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/s0003-9861(03)00157-7

    authors: Podestá FE,Plaxton WC

    更新日期:2003-06-01 00:00:00

  • Structural and immunochemical analysis of three alpha-limit dextrin oligosaccharides.

    abstract::Complete structures are described for three urinary oligodextrins from one patient with type II and one patient with type III glycogen storage disease. GLC-MS, direct probe MS, and 1H NMR demonstrate two heptasaccharides and one hexasaccharide containing only alpha 1-4 and alpha 1-6 linkages. The observation that all ...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/0003-9861(89)90152-5

    authors: Kumlien J,Grönberg G,Nilsson B,Månsson O,Zopf D,Lundblad A

    更新日期:1989-03-01 00:00:00

  • Trehalose and glycerol stabilize and renature yeast inorganic pyrophosphatase inactivated by very high temperatures.

    abstract::A number of naturally occurring small organic molecules, primarily involved in maintaining osmotic pressure in the cell, display chaperone-like activity, stabilizing the native conformation of proteins, and protecting them from various kinds of stress. Most of them are sugars, polyols, amino acids or methylamines. Sim...

    journal_title:Archives of biochemistry and biophysics

    pub_type: 杂志文章

    doi:10.1016/j.abb.2005.09.014

    authors: Zancan P,Sola-Penna M

    更新日期:2005-12-01 00:00:00