Abstract:
:In the present study, we have tested the effect of different polyamine inhibitors of the spermidine metabolizing enzymes deoxyhypusine synthase and homospermidine synthase in different chloroquine resistant Plasmodium falciparum strains, in the mosquito Anopheles stephensi (Diptera: Culicidae) and in a Trypanosoma evansi clone I from strain STIB 806 K China. Recent experiments have shown that agmatine is a growth inhibitor of the malaria parasite P. falciparum (Kaiser et al. 2001) in vitro. A comparison of agmatine efficacy with the new antimalarials artemisinin, triclosan and conventional chloroquine showed similar or even better results on the basis of growth inhibition and the reduction of developmental forms. However, no effect of triclosan or agmatine was observed at the ribonucleic acid level. In a second set of experiments, we tested the effect of 1,7-diaminoheptane and agmatine on oocyst formation in A. stephensi after infection with Plasmodium yoelii. Agmatine had an antisporozoite effect since 1,000 microM led to a 59.5% inhibition of oocysts. A much weaker inhibitor of oocyst formation was 1,7-diaminoheptane. The most effective in in vitro inhibition of T. evansi was dicyclohexylamine, an inhibitor of spermidine biosynthesis with an IC(50 ) value of 47.44 microM and the deoxyhypusine inhibitor 1,7-diaminoheptane with an IC(50) value of 47.80 microM. However, both drugs were ineffective in in vivo experiments in a Trypanosoma mouse model. Two different spermidine analogues, 1,8-diaminooctane and 1,3-diaminopropane with IC(50) values of 171 microM and 181.37 microM, respectively, were moderate inhibitors in vitro and ineffective in vivo.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Moritz E,Seidensticker S,Gottwald A,Maier W,Hoerauf A,Njuguna JT,Kaiser Adoi
10.1007/s00436-004-1162-0subject
Has Abstractpub_date
2004-09-01 00:00:00pages
37-48issue
1eissn
0932-0113issn
1432-1955journal_volume
94pub_type
杂志文章abstract::Both the oncospheral tegument and the hook region membrane (HRM) of Echinococcus multilocularis hexacanths originate from a syncytial binucleate complex that appears in the early stage of morphogenesis and organogenesis of the hexacanth larva. The primordium of this binucleate complex forms a binucleate syncytial cap ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-018-5752-7
更新日期:2018-03-01 00:00:00
abstract::Due to the global health problems associated with mosquito-borne diseases, over two million people primarily in the tropical countries are at risk. The widely and commonly used chemical method though effective, has some major disadvantages making insect control practically difficult. In view of the above, it is unavoi...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-011-2261-3
更新日期:2011-08-01 00:00:00
abstract::Chagas' disease, which is an important health problem in humans, is caused by the protozoan Trypanosoma cruzi. The cellular and molecular mechanisms, involved in the selective tropism of T. cruzi to different organs remain largely unknown. In this study we designed a PCR-based molecular diagnosis method in order to st...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-002-0787-0
更新日期:2003-04-01 00:00:00
abstract::Results obtained in experiments testing the efficacy of anti-procyclic-form rabbit sera on the development of homologous and heterologous stocks of Trypanosoma brucei brucei in Glossina morsitans morsitans indicated that this development was affected little, or not at all, by such sera. The absence of effect of anti-p...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00934382
更新日期:1991-01-01 00:00:00
abstract::With the objective of identifying the helminths of Paroaria coronata, 40 birds were necropsied, and their organs and contents were examined. The parasites were preserved in 70 masculineGL alcohol and prepared for identification using standard techniques. The helminth fauna found in P. coronata were Aproctella carinii,...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-009-1569-8
更新日期:2009-10-01 00:00:00
abstract::In schistosomiasis a systemic hyperplasia of the monomacrophagic cell lineage is associated with its mild modifications in myelograms and hemograms. We monitored the in vitro proliferation of myeloid precursors obtained from bone marrow, blood, spleen, and liver. The macrophage colony-forming unit (M-CFU) numbers were...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360050467
更新日期:1998-08-01 00:00:00
abstract::The metacercarial cyst walls of Paragonimus westermani, P. miyazakii, P. ohirai, and P. iloktsuenensis were examined using ultrastructural and histochemical techniques. The cyst walls of P. westermani, P. miyazakii, and P. ohirai were found to have five distinct layers, whereas the wall of P. iloktsuenensis had only t...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00931563
更新日期:1992-01-01 00:00:00
abstract::A good CD8+ response is required for immunity to many intracellular pathogens. Traditional antigen delivery using isolated sub-units or killed pathogens and adjuvant stimulates strong antibody responses but weak T-cell reactivity. Attenuated vaccines are usually more effective. The prime-boost delivery system based on...
journal_title:Parasitology research
pub_type: 杂志文章,评审
doi:10.1007/s00436-001-0572-5
更新日期:2002-05-01 00:00:00
abstract::Antigens derived from Echinococcus granulosus, Taenia hydatigena and T. pisiformis cyst fluids, T. solium cysticerci, E. multilocularis protoscoleces and E. vogeli cyst membranes were examined by enzyme-linked immunosorbent assay (ELISA) and immunoelectrophoresis (IEP) using four monoclonal antibodies (mAb) to E. gran...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00931225
更新日期:1993-01-01 00:00:00
abstract::Fecal specimens from 432 pre-weaned calves younger than 35 days were collected over a 2-year period (2010-2012) from 74 dairy cattle farms in the central area of Colombia. These samples were microscopically examined for the presence of Cryptosporidium oocysts, and positive specimens were selected for molecular examina...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-018-5818-6
更新日期:2018-05-01 00:00:00
abstract::Blastocystis is an enteric protozoan parasite commonly found in humans and animals. Phylogenetic and genotypic analyses have shown that Blastocystis exhibits extreme genetic diversity, and humans are host to a number of zoonotic isolates. In the present study, the prevalence of Blastocystis in 276 stool samples from a...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-007-0808-0
更新日期:2008-03-01 00:00:00
abstract::Culex pipiens pallens is the mosquito vector of a number of human pathogens such as Wuchereria bancrofti, Brugia malayi, and epidemic encephalitis B virus. Female C. pipiens pallens play an important role in transmitting pathogens by sucking blood, which is essential for reproduction. In the present study, a subtracti...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-007-0506-y
更新日期:2007-08-01 00:00:00
abstract::Wallinia caririensis n. sp. is described from the intestine of Astyanax bimaculatus (Linnaeus, 1758) (Characidae) collected in the Batateiras River in the municipality of Crato, Ceará state, Brazil. The description was based on integrative taxonomy approach using DNA sequences from the D1-D3 domains of the 28S rDNA ge...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06948-1
更新日期:2020-11-25 00:00:00
abstract::The artemisinin-based combination therapy (ACT) is adopted by several countries as first line for malaria treatment in the last decade. Concomitantly, the World Health Organization and other research reports showed a dramatic decline in malaria burden in terms of morbidity, mortality and treatment failure (TF). The op...
journal_title:Parasitology research
pub_type: 杂志文章,评审
doi:10.1007/s00436-009-1700-x
更新日期:2010-02-01 00:00:00
abstract::The Brazilian savannah-like area, the Cerrado region, covers large areas of the country and provides a habitat for a multitude of different animal species. The giant anteater (Myrmecophaga tridactyla) is geographically widespread and one of the typical inhabitants of the Cerrado. They are listed as vulnerable by the I...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-012-3036-1
更新日期:2012-11-01 00:00:00
abstract::The inhibitory activity of mangiferin (50 mg/kg/die and 100 mg/kg/die) on Cryptosporidium parvum was evaluated in a neonatal mouse model and its activity was compared with that of paromomycin (100 mg/kg/die). At 4 days of age, neonatal Swiss conventional outbred mice were experimentally infected by oral administration...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-006-0165-4
更新日期:2006-07-01 00:00:00
abstract::The progressive visceral infection caused in golden hamsters by Leishmania donovani amastigotes led to gradual impairment of the proliferative response of their splenic (SPMC) or peripheral blood (PBMC) mononuclear cells to in vitro stimulation with leishmanial antigen, with mitogen (concanavalin A), and even with a c...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360050600
更新日期:1999-07-01 00:00:00
abstract::In forensic investigations, immature stages of the fly (egg, larva, or puparia) can be used as entomological evidence at death scenes, not only to estimate the postmortem interval (PMI), analyze toxic substances, and to determine the manner of death but also to indicate the movement of a corpse in homicide cases. Of t...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-007-0660-2
更新日期:2007-10-01 00:00:00
abstract::Haemoproteus spp. and Plasmodium spp. are blood parasites that occur in birds worldwide. Identifying the species within this group is complex, especially in wild birds that present low parasitemia when captured, making morphological identification very difficult. Thus, the use of alternative tools to identify species ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06908-9
更新日期:2020-12-01 00:00:00
abstract::This is the first study dealing with the association between HLA alleles and cystic echinococcosis (CE) in Yemeni patients. The present study aimed to detect the association of HLA-DRB(1) alleles and susceptibility or resistance to CE in Yemeni patients by HLA-DRB(1) typing; first by HLA-DRB(1) amplification using PCR...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-010-1868-0
更新日期:2010-07-01 00:00:00
abstract::Although cystic echinococcosis (CE) is highly endemic in Bulgaria, there is still scarce information about species and/or genotypes of the Echinococcus granulosus complex that infect humans. Our study tackled the genetic diversity of E. granulosus complex in a cohort of 30 Bulgarian CE patients. Ten animal E. granulos...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-017-5386-1
更新日期:2017-03-01 00:00:00
abstract::A case of orotracheal myiasis in an 80-year-old man in coma for 1 week in the intensive care unit of Baskent University Hospital, Ankara, Turkey, is reported. A number of larvae of Wohlfahrtia magnifica were recovered repeatedly from the mouth and from the intubation tube of the patient and were reared to adults to fa...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360050203
更新日期:1997-01-01 00:00:00
abstract::Ticks can significantly affect the health and fitness of the host. Seasonal population dynamics of ticks play a vital role in disease transmission and the shaping of life-history traits of both tick and host. In this study, we examine the seasonal population dynamics of Ixodes hirsti in South Australia. For 2 years, w...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-008-1071-8
更新日期:2008-09-01 00:00:00
abstract::In the gastrointestinal mucosa, mucus produced by goblet cells plays an important role in the defense against various pathogens. It is well known that some helminth parasites are able to up-regulate goblet cell numbers and alter the mucus components. However, the nature of the interactions between the protozoan parasi...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-008-1256-1
更新日期:2009-03-01 00:00:00
abstract::The relationships between inflammation in organs with Toxocara canis larval migration and matrix metalloproteinase-9 (MMP-9) were investigated following the infection of mice with 1,000 infective eggs. Gelatinase activity was defined by gelatin zymography, optimum pH, inhibitor specificity and Western blot analysis. M...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-004-1271-9
更新日期:2005-02-01 00:00:00
abstract::In the State of Amazonas, American tegumentary leishmaniasis is endemic and presents a wide spectrum of clinical variability due to the large diversity of circulating species in the region. Isolates from patients in Manaus and its metropolitan region were characterized using monoclonal antibodies and isoenzymes belong...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-010-2139-9
更新日期:2011-03-01 00:00:00
abstract::Gastrointestinal nematode (GIN) infections are a common constraint to small ruminant industry throughout the world, and among those, haemonchosis has its own significance. Control of GIN primarily relies on the use of anthelmintics, but this approach has become less reliable due to the development of resistance in GIN...
journal_title:Parasitology research
pub_type: 杂志文章,评审
doi:10.1007/s00436-011-2576-0
更新日期:2011-12-01 00:00:00
abstract::A study was made to determine the prevalence of camel trypanosomosis (surra) and its associated risk factors in Borena zone, southern Ethiopia during 2013-2014. A total of 2400 blood samples were collected and examined by the buffy coat and thin blood film laboratory methods, and data were analyzed using the SPSS stat...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4845-9
更新日期:2016-03-01 00:00:00
abstract::The gypsy virus of Drosophila melanogaster is the first identified retrovirus of insects. Its infectious properties have been reported, and it is able to cause diverse mutations of the phenotype in the fruit fly. As a typical endogenous retrovirus, it is transmitted vertically as part of the host genome, but horizonta...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-006-0249-1
更新日期:2007-01-01 00:00:00
abstract::Mosquitoes (Diptera: Culicidae) are a key threat for millions of people worldwide, since they act as vectors for devastating pathogens and parasites. The standard method of utilisation of morphological characters becomes challenging due to various factors such as phenotypical variations. We explored the complementary ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4726-2
更新日期:2016-01-01 00:00:00