Abstract：
:Hepatic enzymes and biochemical parameter values were analysed in the sera of 32 lambs: 12 infected with 1,000 Dicrocoelium dendriticum metacercariae, 12 with 3,000 and eight controls. Blood samples were collected at intervals of 30 days from day 0 post-infection (p.i.). Half the lambs in each group were slaughtered on days 60 and 180 p.i, respectively. A histopathological and ultrastructural study was carried out on the liver, gall bladder and hepatic lymph nodes of all animals. A minute increase was detected in the bilirubin (7%) and albumin (3%) values in the infected lambs (with 30-2,063 worms) in comparison with those of the controls. The hepatic enzyme values did increase, above all aspartate aminotransferase (19%) and alanine aminotransferase (22%), mainly in the lambs tested with 3,000 metacercariae (38% and 48%, respectively). The increase was significant 60 days p.i. The severity of the lesions was closely associated with the parasite burden.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Manga-González MY,Ferreras MC,Campo R,González-Lanza C,Pérez V,García-Marín JFdoi
10.1007/s00436-004-1128-2subject
Has Abstractpub_date
2004-08-01 00:00:00pages
344-55issue
5eissn
0932-0113issn
1432-1955journal_volume
93pub_type
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