Abstract：
:The existing armament of drugs for the treatment and prevention of malaria is inadequate due to development of resistance. In addition to this due to lack of economic enticement the rate of new drug development and new drug discovery in the segment of parasitic diseases is very low as compared to the other segments. This has necessitated the better deployment and usage of existing antimalarial drugs as well as discovery of antimalarial activity of drugs which are well characterized for other diseases; these approaches help to reduce the time and cost required for new drug discovery. The present study evaluated the antimalarial activity of antituberculosis drugs rifampicin, isoniazide, and ethambutol in monotherapy and combination in Plasmodium berghei-infected mice. Animals were observed for mortality, parasite progression, and toxicity for a period of 1 month. Rifampicin + isoniazide and rifampicin + isoniazide + ethambutol treatment resulted in an overall survival rate of 60% compared to 0% in vehicle-fed animals by 4 weeks after post-infection without showing any toxicity.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Aditya NP,Patankar S,Madhusudhan Bdoi
10.1007/s00436-010-1789-ysubject
Has Abstractpub_date
2010-05-01 00:00:00pages
1481-4issue
6eissn
0932-0113issn
1432-1955journal_volume
106pub_type
杂志文章abstract：:The parasite community structure of the neotropical cormorant, Phalacrocorax brasilianus, from two lagoons (Coyuca and Tres Palos) from Guerrero state, México, was examined. Fourteen species of adult helminths (6,391 individuals) from 48 cormorants were identified: 9 digeneans, 1 acanthocephalan, 1 cestode, and 3 nema...
journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2011-11-01 00:00:00
abstract：:The experimental transmission of a recently identified new Theileria (China 1) species pathogenic for sheep and goats in northern China is described. Haemaphysalis qinghaiensis nymphs and adults developed from larvae and nymph engorged on sheep infected with Theileria sp. (China 1) were able to respectively transmit t...
journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1007/s00436-002-0614-7
更新日期：2002-09-01 00:00:00
abstract：:The dog's role as a definitive host for a number of zoonotic parasites has been widely studied and recognized as being a significant public health problem worldwide. This study aimed to report, for the first time, our investigation into the role of dogs as a biological transmitter for Ascaris lumbricoides, via necrops...
journal_title：Parasitology research
pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章,评审
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2008-05-01 00:00:00
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更新日期：2012-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1991-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
abstract：:Turkey's tick fauna is composed of about 32 species in two families and ten genera in mammals, reptiles, and birds. The ticks of veterinary significance in the family Ixodidae comprise seven genera with 28 different species. Ixodes spp. are mostly seen in northern Turkey. It is likely that the high rainfall and the in...
journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2007-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
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abstract：:Angiostrongylus cantonensis is an important zoonotic parasite causing eosinophilic meningitis and eosinophilic meningoencephalitis in humans. In this study, the protein expression profiles of the infective third- and pathogenic fifth-stage larvae (L3 and L5) of this parasite were compared by proteomic techniques. Isol...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4024-4
更新日期：2014-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1932-9
更新日期：2010-09-01 00:00:00
