Abstract：
:The aim of this study was to investigate the in vitro and in vivo efficacies of chemotherapy employing albendazole liposome (L-ABZ), Huaier aqueous extract, and a Huaier aqueous extract/L-ABZ combination against Echinococcus granulosus. Protoscolices of E. granulosus were incubated in vitro with the two drugs, either separately or in combination, at the following final concentrations: 2 mg/mL Huaier aqueous extract, 10 μg/mL L-ABZ, and 2 mg/mL Huaier aqueous extract + 10 μg/mL L-ABZ. Huaier aqueous extract and L-ABZ displayed slower protoscolicidal activity when applied separately than when used in combination. The maximum protoscolicidal effect was found with the combination Huaier aqueous extract + L-ABZ. Despite the low Huaier aqueous extract + L-ABZ concentrations used, protoscolex viability dropped rapidly. In vivo studies were performed on mice injected with protoscolices of E. granulosus. Huaier aqueous extract and L-ABZ were administered three times a week for a period of 4 months by the oral route. Huaier aqueous extract in E. granulosus-infected mice was effective. Combined application of both drugs did increase the treatment efficacy. In conclusion, the outcomes obtained clearly demonstrated that in vitro and in vivo treatment with Huaier aqueous extract and L-ABZ is effective against E. granulosus.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Lv H,Jiang Y,Liao M,Sun H,Zhang S,Peng Xdoi
10.1007/s00436-012-3125-1subject
Has Abstractpub_date
2013-01-01 00:00:00pages
193-8issue
1eissn
0932-0113issn
1432-1955journal_volume
112pub_type
杂志文章abstract：:Monosaccharides, lectins, periodate, trypsin and neuraminidase were used to analyse the process of adhesion of Giardia duodenalis trophozoites to IEC cells, an intestinal epithelial cell line. Addition of N-acetyl-glucosamine, N-acetyl-galactosamine, galactose and fucose to the interaction medium inhibited attachment ...
journal_title：Parasitology research
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journal_title：Parasitology research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2014-02-01 00:00:00
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journal_title：Parasitology research
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更新日期：2018-10-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0159-2
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pub_type： 杂志文章
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Parasitology research
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更新日期：2009-03-01 00:00:00
