Abstract：
:The discovery and optimization of antiparasitic compounds has profited by information-based methods newly emerged in the modern drug development process. The generation of computer models enables the cost-efficient and fast computational screening of virtual compound libraries for biologically active molecules. Two sources of information are available: structure-based drug design utilizes information about the disease target. We describe two different computational approaches, realized as the fast, flexible docking program FlexX and as the de novo design program LUDI. Ligand-based drug design, on the other hand, requires the structures and experimental data from biologically active compounds. Parasitic targets and antiparasitic compounds studied by various information-based methods include trypanosomal trypanothione reductase, antiprotozoal bisphosphonates, and trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Wolf K,Dormeyer Mdoi
10.1007/s00436-002-0773-6subject
Has Abstractpub_date
2003-06-01 00:00:00pages
S91-6eissn
0932-0113issn
1432-1955journal_volume
90 Suppl 2pub_type
杂志文章,评审abstract：:Gross anatomy of muscle and sensory/motor innervation of adult and intramolluscan developmental stages of Echinostoma caproni have been investigated to ascertain the organisation and the functional correlates of any stage-specific patterns of staining. Using indirect immunocytochemistry to demonstrate neuroactive subs...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1120-x
更新日期：2004-06-01 00:00:00
abstract：:Recent studies have shown that hormones could induce anti-parasitic functions of the host immune system; thus, the aim of the present study was to estimate the seroprevalence of Toxoplasma gondii antibodies by an enzyme-linked immunosorbent assay in a Polish population of women and men with hyperprolactinaemia (n = 23...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0824-0
更新日期：2008-03-01 00:00:00
abstract：:The general perception is that cattle are major reservoirs for Cryptosporidium parvum infections in humans and that C. parvum is a major cause of diarrhea and production loss in cattle. Adult cattle may play an important role as cryptic carrier of the infection. Cryptosporidium spp. in asymptomatic adult dairy cattle ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1250-7
更新日期：2009-03-01 00:00:00
abstract：:The acanthocephalan Acanthocephalus dirus is a trophically transmitted parasite that modifies both the physiology and behavior of its intermediate host (isopod) prior to transmission to its definitive host (fish). Infected isopods often contain multiple A. dirus individuals and we examined the relationships between ho...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5279-8
更新日期：2017-01-01 00:00:00
abstract：:This study aimed to identify tick species and to determine their relationship with the Theileria parva seroprevalence in cattle raised under an extensive farming system in North Kivu Province, Democratic Republic of Congo in two agro-ecological zones namely medium (1,000-1,850 m) and high (>1,850 m) altitude. Among th...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3200-7
更新日期：2013-02-01 00:00:00
abstract：:Tungiasis is endemic in many countries in Latin America, the Caribbean and sub-Saharan Africa, and it is associated with severe morbidity. The pathophysiological and immunological characteristics of the ectoparasitosis are not well understood, and no effective therapy is currently available. The aim of this study was ...
journal_title：Parasitology research
pub_type： 杂志文章,评审
doi：10.1007/s00436-007-0731-4
更新日期：2007-12-01 00:00:00
abstract：:Chagas disease, caused by the protozoan Trypanosoma cruzi, remains a serious public health problem in Latin America. In relation to digestive problems, 4.5% of patients show mega syndromes (megacolon) in the chronic phase. In this article, we evaluated intestinal motility at the acute phase of T. cruzi infection throu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0829-8
更新日期：2008-03-01 00:00:00
abstract：:The efficacy of a combination of ivermectin (IVM) and albendazole (ABZ) used as a chemoprophylactic treatment and as treatment of secondary hydatidosis is described for the first time. IVM treatment alone was not effective against Echinococcus granulosus, either when the protoscolices were recently inoculated or when ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0623-6
更新日期：2002-06-01 00:00:00
abstract：:Thunbergia laurifolia Linn (Rang Chuet) possesses antioxidant and anti-inflammatory properties as well as anticancer activities. The aim of the present study was to evaluate the efficacy of T. laurifolia in reducing inflammation from pathological changes in Syrian hamsters infected with the human liver fluke Opisthorc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2846-5
更新日期：2012-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5439-5
更新日期：2017-06-01 00:00:00
abstract：:A survey of the myxosporean fauna of Australian marine fishes revealed the presence of three previously unreported species of Unicapsula (Multivalvulida: Trilosporidae) from sites off Southeast Queensland, off Lizard Island on the Great Barrier Reef, Queensland, and from Jurien Bay in Western Australia. Morphometric d...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3467-3
更新日期：2013-08-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-0888-5
更新日期：2008-05-01 00:00:00
abstract：:Dermanyssus gallinae (Acari: Mesostigmata) is the most important hematophagous ectoparasite in layer farms in many countries. The reproduction rate of the parasite is rapid and can be completed in a week under favorable conditions. The parasite has direct and indirect effects on birds. It can also act as a vector for ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3759-2
更新日期：2014-03-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-1821-2
更新日期：2010-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3556-3
更新日期：2013-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-004-1163-z
更新日期：2004-09-01 00:00:00
abstract：:Sarcocysts were detected in routinely processed histological sections of skeletal muscle, but not cardiac muscle, of two adult male otters (Lutra lutra; Mustelidae) from northern Norway following their post-mortem examination in 1999 and 2000. The sarcocysts were slender, spindle-shaped, up to 970 μm long and 35-70 μm...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4251-8
更新日期：2015-03-01 00:00:00
abstract：:Cabbage butterfly (Pieris rapae), included in the Lepidoptera genus, Pieris family, is the main pest that damages Cruciferae. In this paper, we reported a microsporidian isolate of Nosema species which was isolated from P. rapae in Zhenjiang City, Jiangsu Province, China. The mature spore of this microsporidium is lon...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-2829-6
更新日期：2012-07-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2170-x
更新日期：2011-05-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4086-3
更新日期：2014-11-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-008-1010-8
更新日期：2008-08-01 00:00:00
abstract：:Morphological abnormalities were observed on the cephalic bulb hooklets of advanced third-stage larvae (AdvL(3)) of genus Gnathostoma. The larvae were obtained from the fish "Mexican rivulus" Millerichthys robustus collected from a seasonal pond near Tlacotalpan, Veracruz, Mexico. The abnormalities involved (1) extra ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-009-1604-9
更新日期：2009-11-01 00:00:00
abstract：:The objective of the study was to estimate the prevalence of helminths in the horse population of the state of Brandenburg, Germany. One hundred and twenty-six horse farms in the state were selected by randomised stratified sampling. In total, 1,407 horses across all farms were examined coproscopically. The experiment...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-011-2362-z
更新日期：2011-05-01 00:00:00
abstract：:The effect of incubation of parasites (epimastigote and trypomastigote forms of Trypanosoma cruzi) or macrophages in the presence of tunicamycin (TM) or monensin (M) on the parasite-macrophage association was analysed. Treatment of the parasites with TM, a drug which interferes with the process of N-glycosylation of p...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00930829
更新日期：1989-01-01 00:00:00
abstract：:Two isolates of Trypanosoma cruzi were obtained from the patient Berenice, the first human case of Chagas' disease (Chagas 1909), when she was 55 and 71 years old, respectively. The isolates were characterized on the basis of their epimastigote-trypomastigote differentiation in liquid media and of the electrophoretic ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050106
更新日期：1996-01-01 00:00:00
abstract：:In several studies, different antigenic preparations and diverse immunological tests were applied for serodiagnosis of Fasciola hepatica infections. Most of these preparations showed cross-reactivity with proteins of other parasites. Application of purified antigens might reduce these cross-reactivities. Here, we used...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5049-7
更新日期：2016-08-01 00:00:00
abstract：:Mosquito repellents represent a cleaner and safer alternative for population control and reduce the diseases they carry in large areas of the world. Recently, research has been focused on repellents of natural origins, both crude essential oils and their main constituents. We have observed that, although a large numbe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3827-7
更新日期：2014-05-01 00:00:00
abstract：:Three new myxosporeans of the genus Sphaeromyxa Thélohan 1892 were discovered from the coastal waters off Xiamen in the East China Sea and characterized based on morphological and SSU rDNA data. Sphaeromyxa photopectoralis sp. n. was described from Photopectoralis bindus, and Sphaeromyxa sebastisca sp. n. was describe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06656-w
更新日期：2020-05-01 00:00:00
abstract：:Malarial antigens on the surface of infected erythrocytes have been described by many investigators. However, few of these antigens have been unambiguously demonstrated to be exposed on the surface of erythrocytes. This study demonstrates that mild glutaraldehyde fixation results in the cytoplasmic face of the host me...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932242
更新日期：1993-01-01 00:00:00
abstract：:This study increases the known biodiversity of cnidarian parasites in neotropical bryconid fishes. Two novel Myxobolus species are described based on morphology, ultrastructure and small subunit ribosomal DNA (ssrDNA) sequencing: Myxobolus vetuschicanus n. sp. infecting fins of Salminus franciscanus and Myxobolus mine...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06863-5
更新日期：2020-11-01 00:00:00
