Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?


:The efficacy of a combination of ivermectin (IVM) and albendazole (ABZ) used as a chemoprophylactic treatment and as treatment of secondary hydatidosis is described for the first time. IVM treatment alone was not effective against Echinococcus granulosus, either when the protoscolices were recently inoculated or when they had developed to the metacestode stage. However, the efficacy of IVM and ABZ when used in combination as a prophylactic treatment was 95.72% and 87% with respect to the number and the wet weight of cysts, respectively. These results were higher than in the treatment of secondary hydatidosis, which were 44.8% and 45.26%, respectively. The ultrastructural changes in the germinal layer of the cysts after the treatments are also described.


Parasitol Res


Parasitology research


Moreno MJ,Casado N,Urrea-París MA,Rodríguez-Caabeiro F




Has Abstract


2002-06-01 00:00:00












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    pub_type: 杂志文章,评审


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    authors: Shamsi S,Rogers L,Sales E,Kopf RK,Freire R

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    pub_type: 杂志文章


    authors: Yang Y,Wei H,Qin W,Zheng J

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    journal_title:Parasitology research

    pub_type: 杂志文章


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    journal_title:Parasitology research

    pub_type: 杂志文章


    authors: Urrea-París MA,Moreno MJ,Casado N,Rodriguez-Caabeiro F

    更新日期:2000-12-01 00:00:00

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Iwamatsu T,Miyamoto D,Mitsuno H,Yoshioka Y,Fujii T,Sakurai T,Ishikawa Y,Kanzaki R

    更新日期:2016-04-01 00:00:00