A rationale to design longer lasting mosquito repellents.

Abstract:

:Mosquito repellents represent a cleaner and safer alternative for population control and reduce the diseases they carry in large areas of the world. Recently, research has been focused on repellents of natural origins, both crude essential oils and their main constituents. We have observed that, although a large number of compounds can be efficiently used as mosquito repellents, their efficacy is never higher than those of commercial products DEET and Icaridin. Reasoning that probably specific and exceptionally active repellents might not exist, we focused our research on products that could provide longer protection times with respect to current commercial formulations while being used at lower concentrations. Based on the structure of menthone, a moderate natural repellent, we designed and synthesised some cyclic ketals that, because of their reduced volatility, could be effective for longer periods. In particular, a 1% solution of one of such derivatives can still reduce mosquito bites by 90% after 2 h, while DEET provides the same performance only for 15 min, when used at the same concentration. The approach we illustrate can be applied to other compounds and other systems and offers the additional advantage that derivatives of reduced volatility are also endowed with weaker odours.

journal_name

Parasitol Res

journal_title

Parasitology research

authors

Iovinella I,Pelosi P,Conti B

doi

10.1007/s00436-014-3827-7

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1813-20

issue

5

eissn

0932-0113

issn

1432-1955

journal_volume

113

pub_type

杂志文章
  • Influence of PF1022A on the motility of Angiostrongylus cantonensis in vitro.

    abstract::Our previous in vivo studies on angiostrongyliasis showed that PF1022A had stronger killing effects against female adults than against males. No killing effects were observed against young adult worms in the central nervous system. To characterize the former in vivo action of PF1022A, in vitro effects of PF1022A on th...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050301

    authors: Kachi S,Terada M,Hashimoto H

    更新日期:1997-01-01 00:00:00

  • Detection and genotyping of Cryptosporidium from brown rats (Rattus norvegicus) captured in an urban area of Japan.

    abstract::We investigated the prevalence and genotypes of Cryptosporidium parasite in 50 brown rats (Rattus norvegicus) inhabiting an urban area of Japan. Fecal samples collected from the animals were examined by an immuno-fluorescence assay (IFA). Genomic DNA was extracted directly from fecal sample of each animal and nested P...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-007-0488-9

    authors: Kimura A,Edagawa A,Okada K,Takimoto A,Yonesho S,Karanis P

    更新日期:2007-05-01 00:00:00

  • Strongyloides stercoralis hyper-infection syndrome in HIV+/AIDS patients in Iran.

    abstract::Strongyloides stercoralis is an intestinal nematode in humans, distributed through tropical and subtropical regions of the world. In most individuals, the infection has a chronic nature due to auto-infection at the low level. Accelerated auto-infection, mainly after an alteration in immune status, can cause a syndrome...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-007-0531-x

    authors: Meamar AR,Rezaian M,Mohraz M,Hadighi R,Kia EB

    更新日期:2007-08-01 00:00:00

  • First detection and molecular identification of Entamoeba bovis from Japanese cattle.

    abstract::Thus far, Entamoeba species have been classified based on morphology such as the number of nuclei in mature cysts and their hosts. Using recently developed molecular tools, ruminant Entamoeba spp. are currently classified into four species/genotypes: E. bovis and Entamoeba ribosomal lineages (RL) 1, 2, and 4. However,...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5689-2

    authors: Matsubayashi M,Matsuura Y,Nukata S,Daizi Y,Shibahara T,Teramoto I,Matsuo T,Uni S,Hatta T,Kaneko A,Tsuji N,Sasai K

    更新日期:2018-01-01 00:00:00

  • Localization and immunogenicity of a low molecular weight antigen of Eimeria tenella.

    abstract::A low molecular weight (LMW) antigen recognized by a murine monoclonal antibody (C(3)4F(1)) was localized within endogenous stages of Eimeria tenella (USDA strain 80). Using indirect fluorescent antibody assay and immunoelectron microscopy, the LMW antigen was found in: sporozoites, first, second and third generation ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050693

    authors: Tennyson SA,Barta JR

    更新日期:2000-06-01 00:00:00

  • Evaluation of a rapid immunochromatographic test for the detection of low burden Dirofilaria immitis (heartworm) in dogs and cats.

    abstract::The performance of a rapid immunochromatographic test for the detection of Dirofilaria immitis antigens (Speed Diro™; BVT-Virbac, France) was assessed in 49 experimentally infected dogs and in 244 naturally infected animals; 142 dogs and 102 cats. In experimentally infected dogs, Speed Diro™ showed a sensitivity of 90...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5709-2

    authors: Genchi M,Mangia C,Ferrari N,Loukeri S

    更新日期:2018-01-01 00:00:00

  • The rabbit coccidium Eimeria flavescens Marotel and Guilhon, 1941: an electron microscopic study of its life cycle.

    abstract::The endogenous cycle of Eimeria flavescens was studied in specific pathogen-free rabbits by means of histology and transmission electron microscopy. In total, five asexual generations were observed and two types of meronts and merozoites were found in each generation. Type A gave rise to a smaller number of thick poly...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-003-0946-y

    authors: Pakandl M,Cerník F,Coudert P

    更新日期:2003-10-01 00:00:00

  • Two simple techniques for the safe Sarcoptes collection and individual mite DNA extraction.

    abstract::Availability of mites is a recognized limiting factor of biological and genetic investigations of the genus Sarcoptes. Current methods of deoxyribonucleic acid (DNA) extraction from individual mites also need substantial improvement in efficiency and operator friendliness. We have first developed a technique for effic...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-009-1580-0

    authors: Soglia D,Rambozzi L,Maione S,Spalenza V,Sartore S,Alasaad S,Sacchi P,Rossi L

    更新日期:2009-10-01 00:00:00

  • Case report of systemic coccidiosis in a radiated tortoise (Geochelone radiata).

    abstract::More than 30 species of coccidian parasites have been described in Chelonidae (tortoises and turtles). Eimeria spp. are apparently the most common coccidia in chelonians. Findings of Caryospora cheloniae, Isospora sp., and Mantonella sp. have also been published, but reports about systemic coccidiosis are rare. We des...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-007-0781-7

    authors: Schmidt V,Dyachenko V,Aupperle H,Pees M,Krautwald-Junghanns ME,Daugschies A

    更新日期:2008-02-01 00:00:00

  • Amelioration of type 1 diabetes by recombinant fructose-1,6-bisphosphate aldolase and cystatin derived from Schistosoma japonicum in a murine model.

    abstract::Infection with helminth parasites or the administration of their antigens can prevent or attenuate autoimmune diseases. To date, the specific molecules that prime the amelioration are only limited. In this study, recombinant Schistosoma japonicum cystatin (rSjcystatin) and fructose-1,6-bisphosphate aldolase (rSjFBPA) ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-019-06511-7

    authors: Yan K,Wang B,Zhou H,Luo Q,Shen J,Xu Y,Zhong Z

    更新日期:2020-01-01 00:00:00

  • Detection of a gypsy-like sequence in the genome of the cat flea Ctenocephalides felis (Bouché 1835).

    abstract::The gypsy virus of Drosophila melanogaster is the first identified retrovirus of insects. Its infectious properties have been reported, and it is able to cause diverse mutations of the phenotype in the fruit fly. As a typical endogenous retrovirus, it is transmitted vertically as part of the host genome, but horizonta...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-006-0249-1

    authors: Dahl A,Krämer F,Schnieder T

    更新日期:2007-01-01 00:00:00

  • Assessment of in vivo antimalarial activity of rifampicin, isoniazide, and ethambutol combination therapy.

    abstract::The existing armament of drugs for the treatment and prevention of malaria is inadequate due to development of resistance. In addition to this due to lack of economic enticement the rate of new drug development and new drug discovery in the segment of parasitic diseases is very low as compared to the other segments. T...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-010-1789-y

    authors: Aditya NP,Patankar S,Madhusudhan B

    更新日期:2010-05-01 00:00:00

  • Density of environmental Acanthamoeba and their responses to superheating disinfection.

    abstract::Exposure to viable Acanthamoeba may cause fatal encephalitis and blinding keratitis in humans. Quantification of environmental Acanthamoeba by a reliable analytical assay is essential to assess the risk of human exposure and efficacy of control measures (e.g., superheating). Two DNA binding dyes (ethidium monoazide (E...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-013-3556-3

    authors: Chang CW,Lu LW,Kuo CL,Hung NT

    更新日期:2013-11-01 00:00:00

  • Acetylcholinesterase secreted by Anisakis simplex larvae (Nematoda: Anisakidae) parasitizing herring, Clupea harengus: an inverse relationship of enzyme activity in the host-parasite system.

    abstract::Acetylcholinesterase (AChE) is a key enzyme involved in nerve impulse transmission in both vertebrates and invertebrates. In addition to neuromuscular AChE, many parasitic nematodes synthesize AChE in secretory glands and release the enzyme into their external environment. In this study, we evaluate the activities of ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-014-3878-9

    authors: Podolska M,Nadolna K

    更新日期:2014-06-01 00:00:00

  • The sources and metabolic dynamics of Schistosoma japonicum DNA in serum of the host.

    abstract::The polymerase chain reaction (PCR) assay has turned out to be one of the most potential tools for diagnosis of schistosomiasis. However, the source and metabolic dynamics of Schistosoma japonicum DNA in the blood of hosts is not clear. In this study, rabbit models with monosexual and mixed sexual cercariae infection ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-012-3115-3

    authors: Xu J,Liu AP,Guo JJ,Wang B,Qiu SJ,Sun H,Guan W,Zhu XQ,Xia CM,Wu ZD

    更新日期:2013-01-01 00:00:00

  • Repellent efficacy of a combination containing imidacloprid and permethrin against sand flies (Phlebotomus papatasi) in dogs.

    abstract::Infection in dogs and humans with the protozoan parasite Leishmania are widespread in tropical and subtropical countries around the globe. Sand flies of the order Phlebotomus in the Old World and Lutzomyia in the New World function as the vector of this disease. In dogs, skin lesions are the most prominent signs of ca...

    journal_title:Parasitology research

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00436-003-0905-7

    authors: Mencke N,Volf P,Volfova V,Stanneck D

    更新日期:2003-07-01 00:00:00

  • Analysis of isolates within species of anuran trypanosomes using random amplified polymorphic DNA.

    abstract::A total of 20 decamer primers were used to generate random applied polymorphic DNA (RAPD) markers from 5 isolates of Trypanosoma fallisi, 3 isolates of T. ranarum, 2 isolates of T. rotatorium, and 2 isolates of T. rotatorium-like trypanosomes in addition to 2 species from the American Type Culture Collection, T. chatt...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050062

    authors: Lun ZR,Desser SS

    更新日期:1996-01-01 00:00:00

  • Characterization of development-related genes for the cestode Bothriocephalus acheilognathi.

    abstract::Differential gene expression of mature and immature Bothriocephalus acheilognathi cestodes was analyzed using the suppression subtractive hybridization technique. Five mature-associated cDNAs were isolated and characterized. Virtual Northern blot and RT-PCR analyses confirmed that four of the five genes were upregulat...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-004-1205-6

    authors: Luo HL,Nie P,Chang MX,Song Y,Yao WJ

    更新日期:2004-10-01 00:00:00

  • Experimental cysticercosis and the intrahepatic venous systems in Rattus norvegicus.

    abstract::During the present investigation, alterations in the intrahepatic venous and portal systems in Rattus norvegicus infected with 250, 500, and 1000 Taenia taeniaeformis eggs were studied. The corrosion cast technique was employed, which provides an extrinsic opportunity for study of the three-dimensional orientation of ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050703

    authors: Preet S,Prakash S

    更新日期:2000-06-01 00:00:00

  • Effect of hyperprolactinaemia on Toxoplasma gondii prevalence in humans.

    abstract::Recent studies have shown that hormones could induce anti-parasitic functions of the host immune system; thus, the aim of the present study was to estimate the seroprevalence of Toxoplasma gondii antibodies by an enzyme-linked immunosorbent assay in a Polish population of women and men with hyperprolactinaemia (n = 23...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-007-0824-0

    authors: Dzitko K,Malicki S,Komorowski J

    更新日期:2008-03-01 00:00:00

  • Increasing the known biodiversity of cnidarian parasites of bryconid fishes from South America: two novel Myxobolus species with ultrastructure and ssrDNA-based phylogeny.

    abstract::This study increases the known biodiversity of cnidarian parasites in neotropical bryconid fishes. Two novel Myxobolus species are described based on morphology, ultrastructure and small subunit ribosomal DNA (ssrDNA) sequencing: Myxobolus vetuschicanus n. sp. infecting fins of Salminus franciscanus and Myxobolus mine...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-020-06863-5

    authors: Naldoni J,Carriero MM,Moreira GSA,da Silva MRM,Maia AAM,Adriano EA

    更新日期:2020-11-01 00:00:00

  • Efficacy of abamectin injection against Dermatobia hominis in cattle.

    abstract::The efficacy of abamectin 1%, when injected subcutaneously in cattle at a dose of 200 micrograms/kg body weight, against the larval stages (grubs) of the fly Dermatobia hominis was evaluated in two trials in endemic areas of Brazil and Argentina. Eighteen Holstein x Brahman castrated males and 16 Brahman-cross with na...

    journal_title:Parasitology research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00931889

    authors: Cruz JB,Benitez-Usher C,Cramer LG,Gross SJ,Kohn AB

    更新日期:1993-01-01 00:00:00

  • Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites.

    abstract::Three monoclonal antibodies generated by immunization of mice with Plasmodium berghei-infected red blood cells were found to react with the 75-kDa heat-shock protein (HSP70) present in liver stages and erythrocytic forms of the parasites. These antibodies were shown to react with a recombinant protein encoding the car...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/BF00932618

    authors: Tsuji M,Mattei D,Nussenzweig RS,Eichinger D,Zavala F

    更新日期:1994-01-01 00:00:00

  • Mitochondrial and nuclear ribosomal DNA dataset suggests that Hepatiarius sudarikovi Feizullaev, 1961 is a member of the genus Opisthorchis Blanchard, 1895 (Digenea: Opisthorchiidae).

    abstract::The taxonomy and classification of the family Opisthorchiidae have been revised by several authors with the exclusion or synonymization of some genera. The genus Hepatiarius Feizullaev, 1961 accommodated two species: Hepatiarius sudarikovi Feizullaev, 1961 and H. longissimus Linstow, 1883. Recently, some experts have ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-019-06227-8

    authors: Suleman,Ma J,Khan MS,Sun MM,Muhammad N,He JJ,Zhu XQ

    更新日期:2019-03-01 00:00:00

  • Could ivermectin have a synergic effect with albendazole in hydatidosis therapy?

    abstract::The efficacy of a combination of ivermectin (IVM) and albendazole (ABZ) used as a chemoprophylactic treatment and as treatment of secondary hydatidosis is described for the first time. IVM treatment alone was not effective against Echinococcus granulosus, either when the protoscolices were recently inoculated or when ...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-002-0623-6

    authors: Moreno MJ,Casado N,Urrea-París MA,Rodríguez-Caabeiro F

    更新日期:2002-06-01 00:00:00

  • Prime-boost: the way forward for recombinant vaccines against apicomplexan parasites. A Theileria perspective.

    abstract::A good CD8+ response is required for immunity to many intracellular pathogens. Traditional antigen delivery using isolated sub-units or killed pathogens and adjuvant stimulates strong antibody responses but weak T-cell reactivity. Attenuated vaccines are usually more effective. The prime-boost delivery system based on...

    journal_title:Parasitology research

    pub_type: 杂志文章,评审

    doi:10.1007/s00436-001-0572-5

    authors: Hall R,Adamson R,Boulter N

    更新日期:2002-05-01 00:00:00

  • In vivo studies of the effectiveness of novel N-halomethylated and non-halomethylated quaternary ammonium salts in the topical treatment of cutaneous leishmaniasis.

    abstract::The physicochemical properties of four N-halomethylated and one non-halomethylated ammonium salts, with proven in vitro antileishmanial activity, were determined according to pharmaceutical standard procedures. The effectiveness and toxicity of these compounds were assessed in hamsters infected with Leishmania (Vianni...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-017-5702-9

    authors: Fernandez M,Murillo J,Ríos-Vásquez LA,Ocampo-Cardona R,Cedeño DL,Jones MA,Velez ID,Robledo SM

    更新日期:2018-01-01 00:00:00

  • Clonal growth of Blastocystis hominis in soft agar with sodium thioglycollate.

    abstract::The present report describes a method for establishment of colonies of Blastocystis hominis from single cells in soft agar. The percentage of colony-forming efficiency (% CFE = number of colonies grown/number of cells inoculated x 100) for the cultures was greatly improved by the addition of sodium thioglycollate. Fiv...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s004360050194

    authors: Tan SW,Singh M,Thong KT,Ho LC,Moe KT,Chen XQ,Ng GC,Yap EH

    更新日期:1996-01-01 00:00:00

  • Comparison of microscopy, rapid immunoassay, and molecular techniques for the detection of Giardia lamblia and Cryptosporidium parvum.

    abstract::Giardia lamblia and Cryptosporidium parvum are recognized as the most common protozoan infections in Saudi Arabia. Microscopic examination of stool samples, either direct or concentrated, for the recovery of G. lamblia cysts and trophozoites and C. parvum oocysts is still the most commonly used for the diagnosis of bo...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-013-3319-1

    authors: Elsafi SH,Al-Maqati TN,Hussein MI,Adam AA,Hassan MM,Al Zahrani EM

    更新日期:2013-04-01 00:00:00

  • Isospora coronoideae n. sp. (Apicomplexa: Eimeriidae) from the Australian raven (Corvus coronoides) (Passeriformes: Corvidae) (Linnaeus, 1758) in Western Australia.

    abstract::A new Isospora (Apicomplexa: Eimeriidae) species is described from an Australian raven (Corvus coronoides) in Western Australia. Sporulated oocysts (n = 21) are ovoid, 21.2 (18.4-23.9) μm in length and 18.8 (16.9-20.6) μm in width, with a shape index of 1.13. The bi-layered oocyst wall is smooth and colourless, 1.2 μm...

    journal_title:Parasitology research

    pub_type: 杂志文章

    doi:10.1007/s00436-019-06378-8

    authors: Liu D,Brice B,Elliot A,Ryan U,Yang R

    更新日期:2019-08-01 00:00:00