Abstract：
:Balamuthia mandrillaris is a free-living ameba and an opportunistic agent of lethal granulomatous amebic encephalitis (GAE) in humans and other mammals. Its supposed routes of infection have been largely assumed from what is known about Acanthamoeba spp. and Naegleria fowleri, other free-living amebae and opportunistic encephalitis agents. However, formal proof for any migratory pathway, from GAE patients or from animal models, has been lacking. Here, immunodeficient mice were infected with B. mandrillaris amebae by intranasal instillation, the most likely natural portal of entry. By means of classical and immunohistology, the amebae are shown to adhere to the nasal epithelium, progress along the olfactory nerves, traverse the cribriform plate of the ethmoid bone, and finally infect the brain. A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Kiderlen AF,Laube Udoi
10.1007/s00436-004-1163-zsubject
Has Abstractpub_date
2004-09-01 00:00:00pages
49-52issue
1eissn
0932-0113issn
1432-1955journal_volume
94pub_type
杂志文章abstract：:Companion animals including dogs are one of the important components in One Health. Parasites may cause not only diseases in pet animals but also many zoonotic diseases infecting humans. In this study, we performed a survey of intestinal parasites in fecal specimens (n = 485) collected from outpatient pet dogs with di...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5631-7
更新日期：2018-01-01 00:00:00
abstract：:In many helminthic infections, eotaxin, a CC-chemokine, triggers the mobilization of eosinophils, thus, contributing to an elevated blood and periparasitic eosinophil level. Following an experimental intraperitoneal infection of C57BL6 mice with Echinococcus multilocularis metacestodes, however, we observed the absenc...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-009-1549-z
更新日期：2009-10-01 00:00:00
abstract：:The paucity of human cell lines expressing defined receptors for the cytoadhesion of erythrocytes infected with the human malarial parasite Plasmodium falciparumhas hampered the investigation of this important virulence property. Here, we investigate a permanent cell line derived from a human, malignant schwannoma, te...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0744-y
更新日期：2003-02-01 00:00:00
abstract：:Haemosporidian blood parasites of the Plasmodium genus are the causative agents of avian malaria in many parts of the world. Despite the great diversity of Brazilian avifauna, few studies have been conducted to examine the haemosporidians of wild birds found in the Brazilian Atlantic Forest, especially those kept in c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5465-3
更新日期：2017-07-01 00:00:00
abstract：:The present study uses scanning and transmission electron microscopical observations to examine the haptoral features of the hexabothriid polyopisthocotylean monogenean Rajonchocotyle emarginata from the gills of the elasmobranch Amblyraja radiata. The haptor possesses six equal, pedunculate suckers, each armed with a...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-4973-x
更新日期：2016-06-01 00:00:00
abstract：:Several polymorphic markers, including serine-rich protein genes, have been used for the genotyping of isolates from the morphologically indistinguishable protozoan parasites Entamoeba histolytica, Entamoeba dispar, and Entamoeba nuttalli. Genotypes of tRNA-linked short tandem repeats (STRs) are highly polymorphic, bu...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-013-3664-0
更新日期：2014-01-01 00:00:00
abstract：:As part of a biological inventory of the Rio Lacantún basin in the Biosphere Reserve of Montes Azules from Chiapas State (southeastern, Mexico), the following monogenoid ectoparasites infecting the external surface of the anal opening and the gill lamellae of the freshwater fish Astyanax aeneus (Characidae) in ten str...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3126-0
更新日期：2013-01-01 00:00:00
abstract：:A new neogregarine pathogen of the great spruce bark beetle, Dendroctonus micans (Coleoptera: Curculionidae, Scolytinae), is described based on light microscopy and ultrastructural characteristics. The pathogen infects the fat body and the hemolymph of the beetle. The infection was nonsynchronous so that different dev...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4497-9
更新日期：2015-08-01 00:00:00
abstract：:The principal health problem in small ruminants is helminthiasis and the rapid development of nematode resistance to anthelminthics has limited the success of control in several countries, stimulating the search for alternatives. In this study, extracts of immature fruits of the mango Mangifera indica L. var Ubá were ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3017-4
更新日期：2012-12-01 00:00:00
abstract：:The gullet worm (Gongylonema pulchrum) has been recorded from a variety of mammals worldwide. In an earlier study, we demonstrated two separate transmission cycles in cattle (Bos taurus) and wild mammals in Japan based on nucleotide sequences of the ribosomal RNA gene (rDNA) and cytochrome c oxidase subunit I (cox-1) ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4806-3
更新日期：2016-02-01 00:00:00
abstract：:Limited information exists on serum biochemistry and haematology of the European wild boar, and few correlations have been found between parasitic burden and clinical parameters in this species. Naturally infected wild boars were experimentally treated to study the effect of nematode parasites and ivermectin treatment...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-005-0099-2
更新日期：2006-05-01 00:00:00
abstract：:The nematode Anisakis simplex is a marine parasite that causes allergy as well as anisakiasis. Although five Anisakis allergens have already been identified, immunoblotting studies suggested that unidentified allergens still exist. In this study, an expression cDNA library constructed from A. simplex was subjected to ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-006-0396-4
更新日期：2007-05-01 00:00:00
abstract：:To contribute to the knowledge of the role of small mammals in the transmission cycle of tegumentary leishmaniasis caused by Leishmania braziliensis, we studied the small mammal community and its temporal and spatial association with phlebotominae, as well as small mammal infection by Leishmania spp. by PCR-RFLP analy...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-017-5714-5
更新日期：2018-02-01 00:00:00
abstract：:We assessed the cellular immunological responses to two Plasmodium falciparum liver-stage antigen (LSA)-1-derived T-cell epitopes in healthy Gabonese children and adults. The N-terminal peptide, designated T1, induced interferon (IFN)-gamma production in peripheral blood mononuclear cells (PBMC) from a significantly l...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-002-0703-7
更新日期：2002-12-01 00:00:00
abstract：:Suckling rabbits from six litters were orally inoculated at various ages with oocysts of Eimeria flavescens or Eimeria intestinalis. The total number of oocysts in the ceca served to estimate parasite reproduction. The rabbits at 14 and 16 days old remained uninfected, and in 19-day-old animals, low or no oocyst shedd...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0646-0
更新日期：2007-10-01 00:00:00
abstract：:Prevalence and intensity of gastrointestinal parasites were studied through a longitudinal survey in 400 horses over a 17-month period in an abattoir in Germany. Three hundred and ten horses (77.5 %) were demonstrated harbouring endoparasites either by direct recovery of parasites from the digestive tract and/or in te...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-012-3150-0
更新日期：2013-01-01 00:00:00
abstract：:Cryptosporidium spp. and Giardia duodenalis are protozoan parasites that cause diarrhea in humans and animals. Molecular data on Cryptosporidium spp. and G. duodenalis in calves in the Republic of Korea (ROK) is limited; thus, we investigated the prevalence of Cryptosporidium and Giardia in pre-weaned calves, analyzed...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-019-06482-9
更新日期：2019-12-01 00:00:00
abstract：:Toxoplasma gondii uses a unique mechanism to fulfill its asexual life cycles by which the parasite can infect all the warm-blooded animals including humans. Mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) pathway widely existed in eukaryotic cells mediates the conversion of envir...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-5103-5
更新日期：2016-09-01 00:00:00
abstract：:The prevalence data of Leishmania infantum infection in cats are characterized by a large variability mainly attributed to the differences in diagnostic techniques. In the absence of consensus about the method of choice for diagnosing feline leishmaniosis, the performance of a new immunofluorescence antibody test (IFA...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-020-06627-1
更新日期：2020-04-01 00:00:00
abstract：:Investigations by scanning and transmission electron microscopy and freeze-etching revealed that eyes of adult Rhipicephalus evertsi mimeticus consist of a lens and photoreceptor cells, which are separated by an acellular layer and the hypodermis. The lens contains numerous pore channels, which open beneath the epicut...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00933552
更新日期：1990-01-01 00:00:00
abstract：:Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-015-4339-9
更新日期：2015-04-01 00:00:00
abstract：:We report the ultrastructural alterations induced on epimastigotes by nifurtimox and 5-nitro-2-thienyl-malononitrile (5NO2TM), a novel compound with anti-Trypanosoma cruzi activity. Parasites treated with concentrations of nifurtimox lower than usually employed for this kind of study showed vacuolisation, alterations ...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360100497
更新日期：2002-02-01 00:00:00
abstract：:The structure modulation of follicular cells and the ovarian changes during fourth larval instar and pupal stage of the malaria vector mosquitoes Anopheles pharoensis Theobald were investigated using the light and electron microscopy. The generative organs consist of a pair of polytrophic ovaries (OV), which are oblon...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-4099-y
更新日期：2014-11-01 00:00:00
abstract：:Flame atomic absorption spectrometry was performed to determine the alteration of calcium concentration in the soft parts and shells of Biomphalaria alexandrina and Bulinus truncatus due to the infection with Schistosoma mansoni and S. haematobium, respectively. The results showed significant lowering in the calcium c...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0566-z
更新日期：2007-09-01 00:00:00
abstract：:The purpose of the present study was to assess the effect of crude extracts of marine actinobacteria on larvicidal, repellent, and ovicidal activities against Culex tritaeniorhynchus and Culex gelidus (Diptera: Culicidae). The early fourth instar larvae of C. tritaeniorhynchus and C. gelidus, reared in the laboratory,...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-010-2193-3
更新日期：2011-06-01 00:00:00
abstract：:The present report demonstrates that the Gymnorhynchus gigas plerocercoid possesses various types of endo- and exoproteases with activity against general (azocoll, azocasein, and azoalbumin) and specific substrates (elastin, keratin, collagen, hemoglobin, fibrinogen, plasma, and immunoglobulin G). The activity against...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050508
更新日期：1999-01-01 00:00:00
abstract：:Some cyclophyllidean cestodes provide protection for their eggs in the external environment by providing them with additional protective layers around the egg membranes. In attempting to examine such adaptations, the microanatomy and fine structure of the uterus of pregravid and gravid proglottids of the cyclophyllide...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-016-4997-2
更新日期：2016-06-01 00:00:00
abstract：:Serum and colostrum were collected from adult buffalo cows naturally infected with Toxocara vitulorum. When injected into mice, the colostrum reduced the number of larvae of T. vitulorum that migrated in the mice. Injection of particularly the IgG-containing fraction but also the IgM-containing fraction of Sephadex G2...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/BF00932381
更新日期：1994-01-01 00:00:00
abstract：:Numerous nematodes were found in the rectum of three fish species Synodontis ocellifer, S. nigrita, and S. schall (Mochokidae, Siluriformes) from the Gambia River and Mare Simenti, National Park Niokolo Koba, Senegal. A nematode species Raillietnema synodontisi Vassiliadès, 1973 (host S. ocellifer), is redescribed usi...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-007-0869-0
更新日期：2008-04-01 00:00:00
abstract：:Mosquito repellents represent a cleaner and safer alternative for population control and reduce the diseases they carry in large areas of the world. Recently, research has been focused on repellents of natural origins, both crude essential oils and their main constituents. We have observed that, although a large numbe...
journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s00436-014-3827-7
更新日期：2014-05-01 00:00:00
