Abstract：
:The induction of protective immunity to Leishmania amazonensis was investigated by injection of parasite clones of low and medium virulence into susceptible mice. To this end, L. amazonensis were cloned by limiting dilution and the clones' virulence was evaluated by the course of infection in susceptible mice. Clones originally derived from the spleen showed virulence variations in comparison with that of the parental population (PP) of parasites. Two low-virulence clones (SP 5 and SP 20) and one medium-virulence clone (SP 11), representative of the spectrum of derived clones, were compared with virulent parasites and with an avirulent strain (Josefa) as to their ability to induce T-cell immune responses and to protect BALB/c mice from infection with the virulent L. amazonensis PP. Clone SP 20 and clone SP 11 induced partial protection when injected by the intravenous and intradermal route, respectively. The avirulent Josefa strain induced neither T-cell responses nor protection. Low-virulence L. amazonensis clones can therefore be additional tools in vaccine investigation.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
da Fonseca AL,Vallochi AL,Furtado Gde C,Abrahamsohn Ide A,Lima GMdoi
10.1007/s004360050321subject
Has Abstractpub_date
1997-01-01 00:00:00pages
690-7issue
7eissn
0932-0113issn
1432-1955journal_volume
83pub_type
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更新日期：1994-01-01 00:00:00
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更新日期：2016-11-01 00:00:00
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journal_title：Parasitology research
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更新日期：2007-02-01 00:00:00
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journal_title：Parasitology research
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journal_title：Parasitology research
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更新日期：2019-02-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
doi：10.1007/s004360050359
更新日期：1998-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2017-01-01 00:00:00
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journal_title：Parasitology research
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
