Abstract:
:This analysis investigated the influence of breed and gender on the pharmacokinetics of monepantel, and influence of breed, age, and gender on its efficacy against gastrointestinal nematodes of sheep. In a comparison of pharmacokinetic profiles from two studies, Merino lambs had significantly greater maximum concentrations of monepantel and monepantel sulfone, and faster times to reach these concentrations than Dorset cross lambs. Males had a statistically greater area under the curve (0-504 h) than females for monepantel sulfone. The biological relevance of these relatively small differences is unclear because efficacy was not evaluated in these studies. For efficacy, a breed effect existed for some nematodes when sheep were treated at a sub-optimum dose (1.25 mg/kg). There were no gender effects between sheep infected with adult parasites and treated at 1.25 mg/kg but there were differences between females and males treated at this dose when infected with fourth-stage larvae of Haemonchus contortus, Teladorsagia circumcincta, Trichostrongylus colubriformis, and Cooperia curticei. There were no breed or gender differences for sheep treated at the recommended dose (2.5 mg/kg). There was a potential trend for declining efficacy with increasing animal age for fourth-stage Trichostrongylus axei. This analysis demonstrated that, similarly to what is observed with other anthelmintics, the pharmacokinetics and efficacy of monepantel can vary with factors like breed, age, and gender. Identifying these covariates is important for understanding inter-individual variability in drug response. While further investigation is warranted, correctly treating sheep at the recommended dose of 2.5 mg/kg appears to mitigate any associated risk.
journal_name
Parasitol Resjournal_title
Parasitology researchauthors
Hosking BC,Kaminsky R,Sager H,Karadzovska D,Seewald W,Giraudel JM,Vercruysse Jdoi
10.1007/s00436-009-1671-ysubject
Has Abstractpub_date
2010-01-01 00:00:00pages
367-75issue
2eissn
0932-0113issn
1432-1955journal_volume
106pub_type
杂志文章abstract::Immunocytochemical studies using antibodies against various peptides were performed on Echinostoma caproni. Only the presence of substance P or a related peptide was clearly demonstrated in this digenetic trematode. In the central nervous system, substance P-immunoreactive neurons were few and constituted two populati...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00930963
更新日期:1989-01-01 00:00:00
abstract::High resolution two-dimensional separation of Toxoplasma gondii tachyzoite lysate revealed up to 224 distinct protein spots in Coomassie-stained gel. Computional matching of 14 digitized gels yielded a standard two-dimensional proteome map. The excretory T. gondii dense granule proteins GRA1-GRA8, S16/acid phosphatase...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360000367
更新日期:2001-08-01 00:00:00
abstract::The parasite community structure of the neotropical cormorant, Phalacrocorax brasilianus, from two lagoons (Coyuca and Tres Palos) from Guerrero state, México, was examined. Fourteen species of adult helminths (6,391 individuals) from 48 cormorants were identified: 9 digeneans, 1 acanthocephalan, 1 cestode, and 3 nema...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-011-2377-5
更新日期:2011-11-01 00:00:00
abstract::Among tick species, members of the subfamily Amblyomminae have received special attention, since they serve as vectors for pathogens such as Rickettsia spp. and display cryptic species complexes that make their taxonomical classification challenging. Amblyomma ovale, Amblyomma maculatum, and other species of the genus...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-017-5592-x
更新日期:2017-11-01 00:00:00
abstract::Wallinia caririensis n. sp. is described from the intestine of Astyanax bimaculatus (Linnaeus, 1758) (Characidae) collected in the Batateiras River in the municipality of Crato, Ceará state, Brazil. The description was based on integrative taxonomy approach using DNA sequences from the D1-D3 domains of the 28S rDNA ge...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-020-06948-1
更新日期:2020-11-25 00:00:00
abstract::Intestines of California sea lion (Zalophus californianus) pups (n= 204), born in 2002 on San Miguel Island, California, were examined for hookworms (Uncinaria spp.) as part of a seasonal mortality study from June through December 2002 and January 2003. The investigation was planned to coincide with most of the previo...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-005-1335-5
更新日期:2005-05-01 00:00:00
abstract::Potent compounds do not necessarily make the best drugs in the market. Consequently, with the aim to describe tools that may be fundamental for refining the screening of candidates for animal and preclinical studies and further development, molecules of different structural classes synthesized within the frame of a br...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-014-4210-4
更新日期:2015-02-01 00:00:00
abstract::Atmospheric observations demonstrate that, during the last decades, the climate has changed. As reported by the Intergovernmental Panel on Climate Change (IPCC, 2001, 2007), a mean increase of temperature by 0.09 K per decade was observed globally from 1951 to 1989. Up to now, 2008, this trend has continued. Europe ex...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-008-1099-9
更新日期:2008-12-01 00:00:00
abstract::Hepatozoon aegypti Bashtar, Boulos & Mehlhorn, 1984 was first described from the blood of the diadem snake (Spalerosophis diadema) in Egypt. During an investigation of the diversity of reptilian haemogregarines in Saudi Arabia, seven diadem snakes (100% of the sample) were found to be highly parasitised by H. aegypti,...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-018-6006-4
更新日期:2018-10-01 00:00:00
abstract::This study was conducted to evaluate the phytochemical composition and larvicidal effect of leaf essential oil from Murraya exotica against early fourth-instar larvae of Aedes aegypti, Anopheles stephensi and Culex quinquefasciatus. Gas chromatography (GC) and gas chromatography mass spectrometry (GC-MS) analyses reve...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-015-4370-x
更新日期:2015-05-01 00:00:00
abstract::Sheared flagella from Giardia lamblia were freed from cytoskeleton fragments and other cell contaminants by centrifuging in a density gradient. The purified organelles contain many polypeptides, including a set of low-molecular-weight antigens [apparent molecular weights (MWs) = 31, 32, 34, 35 and 37 kD] in the same s...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/BF00535140
更新日期:1988-01-01 00:00:00
abstract::Exposure to viable Acanthamoeba may cause fatal encephalitis and blinding keratitis in humans. Quantification of environmental Acanthamoeba by a reliable analytical assay is essential to assess the risk of human exposure and efficacy of control measures (e.g., superheating). Two DNA binding dyes (ethidium monoazide (E...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-013-3556-3
更新日期:2013-11-01 00:00:00
abstract::Haematophagous leeches express a broad variety of bioactive factors that are released from the salivary gland cells into the wound of a host during feeding. Among these, hirudin is probably the best studied factor and, moreover, the only one that has successfully made the transition from nature to clinical use. Many c...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-016-5294-9
更新日期:2017-01-01 00:00:00
abstract::Morphological abnormalities were observed on the cephalic bulb hooklets of advanced third-stage larvae (AdvL(3)) of genus Gnathostoma. The larvae were obtained from the fish "Mexican rivulus" Millerichthys robustus collected from a seasonal pond near Tlacotalpan, Veracruz, Mexico. The abnormalities involved (1) extra ...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-009-1604-9
更新日期:2009-11-01 00:00:00
abstract::Blastocystis hominis is a common intestinal parasite observed in fecal examination. On the other hand, the transmission of this parasite is certainly unknown. The transmission of B. hominis can be realized by animal contact and the contamination by water and food with excreted cysts from the reservoir hosts. B. homini...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-010-1937-4
更新日期:2010-09-01 00:00:00
abstract::Pharmacokinetics and anthelmintic activity of topical eprinomectin in goats prevented from physical contact to others and self-grooming were studied. Sixteen approximately 7 months old male castrated German White Noble goats harbouring induced infections of gastrointestinal nematode parasites were included in the stud...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-014-4072-9
更新日期:2014-11-01 00:00:00
abstract::Pathogen-free rainbow trout (Oncorhynchus mykiss) aged 735 degree days were experimentally exposed to a low dose of infectious Myxobolus cerebralis (20 triactinomyxons fish(-1)). Three time periods were chosen for sampling that included 10 days (d), 67 d, and 5 months (mo) post exposure. Five diagnostic assays were us...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-006-0166-3
更新日期:2006-09-01 00:00:00
abstract::Monogamy is a mating system with pairs made of only one male and only one female. But social monogamy cannot inevitably imply the sexual exclusivity between mates, which is yet the case in genetic monogamy on which the offspring results only from the observed pair. The genetic monogamy is today considered as an except...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-008-1225-8
更新日期:2009-01-01 00:00:00
abstract::Human colonisation of New Zealand has resulted in the introduction of emerging diseases, such as avian malaria and toxoplasmosis, which arrived with their exotic avian and mammalian hosts. Plasmodium spp. and Toxoplasma gondii have a wide host range, and several species of endemic New Zealand birds have developed a fa...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-017-5536-5
更新日期:2017-08-01 00:00:00
abstract::Chagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi), although discovered more than a century ago, is still a not very well-elucidated aspect. Individuals in the chronic phase of the disease may present asymptomatic clinical form or symptomatologies related to the cardiac, digestive systems, or both (m...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-019-06377-9
更新日期:2019-08-01 00:00:00
abstract::We evaluated serum examination as an alternative to fecal analysis for the diagnosis of exposure to Cryptosporidium parvum in cattle. The accuracy of the serum ELISA was compared to the combined results of concentration flotation microscopy and fecal enzyme immunoassay. The expected performance of the serum ELISA at d...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-002-0665-9
更新日期:2002-09-01 00:00:00
abstract::The dynamics of production and excretion of leukotrienes by parasitic larvae of Oesophagostomum dentatum and their role for the development of the larvae were studied. Larvae were cultured in vitro to the fourth stage (L4). Leukotriene B4 (LTB4) was detected in homogenates and in supernatant of larvae, with the homoge...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360050138
更新日期:1996-01-01 00:00:00
abstract::In the present study, we have tested the effect of different polyamine inhibitors of the spermidine metabolizing enzymes deoxyhypusine synthase and homospermidine synthase in different chloroquine resistant Plasmodium falciparum strains, in the mosquito Anopheles stephensi (Diptera: Culicidae) and in a Trypanosoma eva...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-004-1162-0
更新日期:2004-09-01 00:00:00
abstract::Isometamidium chloride (ISM) is an effective trypanocide with curative and prophylactive activity in husbandry animals. The mode of action of ISM against pathogenic trypanosomes is not fully understood, but there is evidence in the literature that kinetoplastic topoisomerase type II is selectively inhibited by the dru...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s004360050346
更新日期:1997-01-01 00:00:00
abstract::A multicomponent DNA vaccine, encoding Toxoplasma gondii GRA1 and SAG1, was constructed and tested for its ability to confer protection. BALB/c mice were challenged with tachyzoites of the virulent T. gondii RH strain at 4 weeks following the last immunization, and immune responses and survival times were observed. Th...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-012-3047-y
更新日期:2012-11-01 00:00:00
abstract::The history of European bison Bison bonasus Linnaeus, 1758 has been stormy since its extinction in the wild after the First World War. Due to the fact that the species was restored from just 12 founders, further expansion has suffered from low genetic variability, rendering the bison vulnerable to various pathogens du...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-017-5663-z
更新日期:2018-01-01 00:00:00
abstract::The vitellarium of the invasive caryophyllidean tapeworm Khawia sinensis Hsü, 1935 from carp Cyprinus carpio L. was examined by means of transmission electron microscopy and cytochemical staining for glycogen with periodic acid-thiosemicarbazide-silver proteinate (PA-TSC-SP). A vitellarium consists of numerous follicl...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-013-3477-1
更新日期:2013-07-01 00:00:00
abstract::Equine ocular setariasis arising mainly from ectopic infestation of Setaria digitata is a common vision impairing ophthalmic disease in India, and the identification of this filarial nematode is based solely on morphology. However, morphological characters alone are inadequate to detect and differentiate S. digitata f...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-019-06587-1
更新日期:2020-02-01 00:00:00
abstract::The purpose of the present study was to assess the effect of crude extracts of marine actinobacteria on larvicidal, repellent, and ovicidal activities against Culex tritaeniorhynchus and Culex gelidus (Diptera: Culicidae). The early fourth instar larvae of C. tritaeniorhynchus and C. gelidus, reared in the laboratory,...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-010-2193-3
更新日期:2011-06-01 00:00:00
abstract::Thelaziasis is an ocular infection of several mammals caused by nematodes of the genus Thelazia (Spirurida, Thelaziidae). The adults live in the lachrymal ducts and conjunctival sacs of infected animals, and transmission occurs by means of different species of muscids. T. rhodesi, T. skrjabini, and T. gulosa affect ma...
journal_title:Parasitology research
pub_type: 杂志文章
doi:10.1007/s00436-006-0432-4
更新日期:2007-06-01 00:00:00