Capn5 is expressed in a subset of T cells and is dispensable for development.

abstract：:Two mutator genes of mammalian cells were demonstrated. One was associated with the ribonucleoside diphosphate reductase, and the other was associated with an extreme adenosine sensitivity. ...

journal_title：Molecular and cellular biology

authors： Chan VL,Guttman S,Juranka P

更新日期：1981-06-01 00:00:00

abstract：:Two Drosophila tumor necrosis factor receptor-associated factors (TRAF), DTRAF1 and DTRAF2, are proposed to have similar functions with their mammalian counterparts as a signal mediator of cell surface receptors. However, their in vivo functions and related signaling pathways are not fully understood yet. Here, we sho...

journal_title：Molecular and cellular biology

authors： Cha GH,Cho KS,Lee JH,Kim M,Kim E,Park J,Lee SB,Chung J

更新日期：2003-11-01 00:00:00

abstract：:The selenoenzyme phospholipid hydroperoxide glutathione peroxidase (PHGPx) is regarded as the major molecular target of selenodeficiency in rodents, accounting for most of the histopathological and structural abnormalities of testicular tissue and male germ cells. PHGPx exists as a cytosolic form, mitochondrial form, ...

journal_title：Molecular and cellular biology

authors： Conrad M,Moreno SG,Sinowatz F,Ursini F,Kölle S,Roveri A,Brielmeier M,Wurst W,Maiorino M,Bornkamm GW

更新日期：2005-09-01 00:00:00

abstract：:mof6-1 was originally isolated as a recessive mutation in Saccharomyces cerevisiae which promoted increased efficiencies of programmed -1 ribosomal frameshifting and rendered cells unable to maintain the killer virus. Here, we demonstrate that mof6-1 is a unique allele of the histone deacetylase RPD3, that the deacety...

journal_title：Molecular and cellular biology

authors： Meskauskas A,Baxter JL,Carr EA,Yasenchak J,Gallagher JE,Baserga SJ,Dinman JD

更新日期：2003-03-01 00:00:00

abstract：:Plasmids containing the hormone regulatory element of mouse mammary tumor virus linked to the thymidine kinase promoter of herpes simplex virus and the reporter gene chloramphenicol acetyltransferase of Escherichia coli respond to glucocorticoids and progestins when transfected into appropriate cells. In the human mam...

journal_title：Molecular and cellular biology

authors： Piña B,Haché RJ,Arnemann J,Chalepakis G,Slater EP,Beato M

更新日期：1990-02-01 00:00:00

abstract：:Interleukin 1 (IL-1) induces the synthesis of kappa immunoglobulin light chains and the expression of surface immunoglobulin in the murine pre-B-cell line 70Z/3 (J. G. Giri, P. W. Kincade, and S. B. Mizel, J. Immunol. 132:223-228, 1984). In the present study, we found that these effects of IL-1 are mimicked by cyclic ...

journal_title：Molecular and cellular biology

authors： Shirakawa F,Chedid M,Suttles J,Pollok BA,Mizel SB

更新日期：1989-03-01 00:00:00

abstract：:Using a subtractive cloning scheme on cDNA prepared from primary pro-B and pre-B cells, we identified several genes whose products regulate apoptosis. We further characterized one of these genes, encoding protein kinase Ceta (PKCeta). PKCeta transcripts were readily detected in pro-B cells but were absent in pre-B cel...

journal_title：Molecular and cellular biology

authors： Morrow TA,Muljo SA,Zhang J,Hardwick JM,Schlissel MS

更新日期：1999-08-01 00:00:00

abstract：:Binding of the thyroid hormone receptor (TR) to thyroid hormone-responsive elements (TREs) is crucial for regulation of gene expression by thyroid hormone. The TR binds to each half-site of a palindromic TRE separately, as a monomer, or simultaneously, as a homodimer. In addition, the TR monomer interacts with a 42-kD...

journal_title：Molecular and cellular biology

authors： Lazar MA,Berrodin TJ,Harding HP

更新日期：1991-10-01 00:00:00

abstract：:We have previously proposed that the upstream regions of the human cardiac actin gene contain sequences that interact with muscle-specific factors with direct high-level transcription of this gene in differentiated muscle cells. In this study we showed that these factors already accumulate in the dividing myoblasts of...

journal_title：Molecular and cellular biology

authors： Minty A,Blau H,Kedes L

更新日期：1986-06-01 00:00:00

abstract：:Although the splicing of transcripts from most eukaryotic genes occurs in a constitutive fashion, some genes can undergo a process of alternative splicing. This is a genetically economical process which allows a single gene to give rise to several protein isoforms by the inclusion or exclusion of sequences into or fro...

journal_title：Molecular and cellular biology

authors： Bell MV,Cowper AE,Lefranc MP,Bell JI,Screaton GR

更新日期：1998-10-01 00:00:00

abstract：:The human 4F2 cell surface antigen is a 120-kilodalton (kDa) disulfide-linked heterodimer which is composed of an 80- to 90-kDa glycosylated heavy chain (4F2HC) and a 35- to 40-kDa nonglycosylated light chain (4F2LC). 4F2 belongs to a family of inducible cell surface molecules which are involved in T-lymphocyte activa...

journal_title：Molecular and cellular biology

authors： Gottesdiener KM,Karpinski BA,Lindsten T,Strominger JL,Jones NH,Thompson CB,Leiden JM

更新日期：1988-09-01 00:00:00

abstract：:CHIP is a cochaperone of Hsp70 that inhibits Hsp70-dependent refolding in vitro. However, the effect of altered expression of CHIP on the fate of unfolded proteins in mammalian cells has not been determined. Surprisingly, we found that overexpression of CHIP in fibroblasts increased the refolding of proteins after the...

journal_title：Molecular and cellular biology

authors： Kampinga HH,Kanon B,Salomons FA,Kabakov AE,Patterson C

更新日期：2003-07-01 00:00:00

abstract：:The tumor suppressor protein ARF inhibits MDM2 to activate and stabilize p53. Recent studies provided evidence for p53-independent tumor suppression functions of ARF. For example, it has been shown that ARF induces proteolysis of certain E2F species, including E2F1. In addition, ARF relocalizes E2F1 from the nucleopla...

journal_title：Molecular and cellular biology

authors： Datta A,Nag A,Raychaudhuri P

更新日期：2002-12-01 00:00:00

abstract：:Expression of the yeast pyrimidine biosynthetic gene, URA3, is induced three- to fivefold in response to uracil starvation, and this regulation is mediated by the transcriptional activator PPR1 (pyrimidine pathway regulator 1). In this study, we have analyzed the regulatory elements of the URA3 promoter by DNase I foo...

journal_title：Molecular and cellular biology

authors： Roy A,Exinger F,Losson R

更新日期：1990-10-01 00:00:00

abstract：:In the present study we have analyzed the genetic regulation of increased expression of transformation-associated traits, a process termed progression, in adenovirus type 5 (Ad5)-transformed secondary rat embryo cells. Somatic cell hybrids were formed between a highly progressed neomycin-resistant Ad5-transformed clon...

journal_title：Molecular and cellular biology

authors： Duigou GJ,Babiss LE,Iman DS,Shay JW,Fisher PB

更新日期：1990-05-01 00:00:00

abstract：:The functional receptor for insect ecdysteroid hormones is a heterodimer consisting of two nuclear hormone receptors, ecdysteroid receptor (EcR) and the retinoid X receptor homologue Ultraspiracle (USP). Although ecdysone is commonly thought to be a hormone precursor and 20-hydroxyecdysone (20E), the physiologically a...

journal_title：Molecular and cellular biology

authors： Wang SF,Ayer S,Segraves WA,Williams DR,Raikhel AS

更新日期：2000-06-01 00:00:00

abstract：:macroH2A histone variants have been implicated to function in gene silencing by several studies, including ones showing a preferential association of macroH2A on the inactive X chromosome. To examine macroH2A function in vivo, we knocked out macroH2A1. macroH2A1 knockout mice are viable and fertile. A broad screen of ...

journal_title：Molecular and cellular biology

authors： Changolkar LN,Costanzi C,Leu NA,Chen D,McLaughlin KJ,Pehrson JR

更新日期：2007-04-01 00:00:00

abstract：:Five mouse alpha-tubulin isotypes are described, each distinguished by the presence of unique amino acid substitutions within the coding region. Most, though not all of these isotype-specific amino acids, are clustered at the carboxy terminus. One of the alpha-tubulin isotypes described is expressed exclusively in tes...

journal_title：Molecular and cellular biology

authors： Villasante A,Wang D,Dobner P,Dolph P,Lewis SA,Cowan NJ

更新日期：1986-07-01 00:00:00

abstract：:A molecular karyotype of Neurospora crassa was obtained by using an alternating-field gel electrophoresis system which employs contour-clamped homogeneous electric fields. The migration of all seven N. crassa chromosomal DNAs was defined, and five of the seven molecules were separated from one another. The estimated s...

journal_title：Molecular and cellular biology

authors： Orbach MJ,Vollrath D,Davis RW,Yanofsky C

更新日期：1988-04-01 00:00:00

abstract：:The canonical Notch signaling pathway mediated by Delta- and Jagged-like Notch ligands determines a variety of cell fates in metazoa. In Caenorhabditis elegans and sea urchins, canonical Notch signaling is essential for different cell fate specifications during early embryogenesis or the formation of endoderm, mesoder...

journal_title：Molecular and cellular biology

authors： Shi S,Stahl M,Lu L,Stanley P

更新日期：2005-11-01 00:00:00

abstract：:Keratin 6 (K6) expression in the epidermis has two components: constitutive expression in the innermost layer of the outer root sheath (ORS) of hair follicles and inducible expression in the interfollicular epidermis in response to stressful stimuli such as wounding. Mice express two K6 isoforms, MK6a and MK6b. To gai...

journal_title：Molecular and cellular biology

authors： Wojcik SM,Bundman DS,Roop DR

更新日期：2000-07-01 00:00:00

abstract：:The gastrointestinal glutathione peroxidase (GI-GPx, GPx2) is a selenoprotein that was suggested to act as barrier against hydroperoxide absorption but has also been implicated in the control of inflammation and malignant growth. In CaCo-2 cells, GI-GPx was induced by t-butyl hydroquinone (tBHQ) and sulforaphane (SFN)...

journal_title：Molecular and cellular biology

authors： Banning A,Deubel S,Kluth D,Zhou Z,Brigelius-Flohé R

更新日期：2005-06-01 00:00:00

abstract：:The mouse urokinase-type plasminogen activator (uPA) gene was used as a model macrophage colony-stimulating factor 1 (CSF-1)-inducible gene to investigate CSF-1 signalling pathways. Nuclear run-on analysis showed that induction of uPA mRNA by CSF-1 and phorbol myristate acetate (PMA) was at the transcriptional level i...

journal_title：Molecular and cellular biology

authors： Stacey KJ,Fowles LF,Colman MS,Ostrowski MC,Hume DA

更新日期：1995-06-01 00:00:00

abstract：:The cyclin-dependent kinase (CDK)-activating kinase (CAK) is involved in cell cycle control, transcription, and DNA repair (E. A. Nigg, Curr. Opin. Cell. Biol. 8:312-317, 1996). However, the mechanisms of how CAK is integrated into these signaling pathways remain unknown. We previously demonstrated that abrogation of ...

journal_title：Molecular and cellular biology

authors： Wu L,Chen P,Shum CH,Chen C,Barsky LW,Weinberg KI,Jong A,Triche TJ

更新日期：2001-01-01 00:00:00

abstract：:The connections between various nuclear processes and specific histone posttranslational modifications are dependent to a large extent on the acquisition of those modifications after histone synthesis. The reestablishment of histone posttranslational modifications after S phase is especially critical for H3K9 and H3K2...

journal_title：Molecular and cellular biology

authors： Zee BM,Britton LM,Wolle D,Haberman DM,Garcia BA

更新日期：2012-07-01 00:00:00

abstract：:Independent of its antiapoptotic function, Bcl-2 can, through an undetermined mechanism, retard entry into the cell cycle. Cell cycle progression requires the phosphorylation by cyclin-dependent kinases (Cdks) of retinoblastoma protein (pRB) family members to free E2F transcription factors. We have explored whether re...

journal_title：Molecular and cellular biology

authors： Vairo G,Soos TJ,Upton TM,Zalvide J,DeCaprio JA,Ewen ME,Koff A,Adams JM

更新日期：2000-07-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) play key roles in differentiation, growth, proliferation, and apoptosis. Although MAPKs have been extensively studied, the precise function, specific substrates, and target genes of each MAPK are not known. These issues could be addressed by sole activation of a given MAPK, e....

journal_title：Molecular and cellular biology

authors： Yaakov G,Bell M,Hohmann S,Engelberg D

更新日期：2003-07-01 00:00:00

abstract：:The ETS transcription factor complex GABP consists of the GABPalpha protein, containing an ETS DNA binding domain, and an unrelated GABPbeta protein, containing a transactivation domain and nuclear localization signal. GABP has been shown in vitro to regulate the expression of nuclear genes involved in mitochondrial r...

journal_title：Molecular and cellular biology

authors： Ristevski S,O'Leary DA,Thornell AP,Owen MJ,Kola I,Hertzog PJ

更新日期：2004-07-01 00:00:00

abstract：:Insults to cellular health cause p53 protein accumulation, and loss of p53 function leads to tumorigenesis. Thus, p53 has to be tightly controlled. Here we report that the BTB/POZ domain transcription factor PATZ1 (MAZR), previously known for its transcriptional suppressor functions in T lymphocytes, is a crucial regu...

journal_title：Molecular and cellular biology

authors： Keskin N,Deniz E,Eryilmaz J,Un M,Batur T,Ersahin T,Cetin Atalay R,Sakaguchi S,Ellmeier W,Erman B

更新日期：2015-05-01 00:00:00

abstract：:Epidermal growth factor (EGF) induces tyrosine phosphorylation of the Shc adapter protein, which plays an important role in EGF-stimulated mitogenesis. Shc stimulates Ras/mitogen-activated protein kinase (MAPK) through forming a complex with Grb2 at the phosphorylated tyrosine (Y) residue 317. In this study, we identi...

journal_title：Molecular and cellular biology

authors： Gotoh N,Toyoda M,Shibuya M

更新日期：1997-04-01 00:00:00