MAT1-modulated CAK activity regulates cell cycle G(1) exit.

abstract：:Neurite outgrowth is key to the formation of functional circuits during neuronal development. Neurotrophins, including nerve growth factor (NGF), increase neurite outgrowth in part by altering the function and expression of Ca(2+)-permeable cation channels. Here we report that transient receptor potential vanilloid 2 ...

journal_title：Molecular and cellular biology

authors： Cohen MR,Johnson WM,Pilat JM,Kiselar J,DeFrancesco-Lisowitz A,Zigmond RE,Moiseenkova-Bell VY

更新日期：2015-12-01 00:00:00

abstract：:Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac...

journal_title：Molecular and cellular biology

authors： Kedzierski RM,Grayburn PA,Kisanuki YY,Williams CS,Hammer RE,Richardson JA,Schneider MD,Yanagisawa M

更新日期：2003-11-01 00:00:00

abstract：:CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain uncle...

journal_title：Molecular and cellular biology

authors： Wang P,Luo Y,Duan H,Xing S,Zhang J,Lu D,Feng J,Yang D,Song L,Yan X

更新日期：2013-09-01 00:00:00

abstract：:Multiple organ systems require epithelial barriers for normal function, and barrier loss is a hallmark of diseases ranging from inflammation to epithelial cancers. However, the molecular processes regulating epithelial barrier maturation are not fully elucidated. After contact, epithelial cells undergo size-reductive ...

journal_title：Molecular and cellular biology

authors： Bolinger MT,Ramshekar A,Waldschmidt HV,Larsen SD,Bewley MC,Flanagan JM,Antonetti DA

更新日期：2016-07-14 00:00:00

abstract：:Immunoglobulin (Ig) mu heavy-chain gene enhancer activity is mediated by multiple DNA binding proteins. Mutations of several protein binding sites in the enhancer do not affect enhancer activity significantly. This feature, termed redundancy, is thought to be due to functional compensation of the mutated sites by othe...

journal_title：Molecular and cellular biology

authors： Dang W,Nikolajczyk BS,Sen R

更新日期：1998-11-01 00:00:00

abstract：:Mdm2, a regulator of the tumor suppressor p53, is frequently overexpressed in human malignancies. Mdm2 also has unresolved, p53-independent functions that contribute to tumorigenesis. Here, we show that increased Mdm2 expression induced chromosome/chromatid breaks and delayed DNA double-strand break repair in cells la...

journal_title：Molecular and cellular biology

authors： Bouska A,Lushnikova T,Plaza S,Eischen CM

更新日期：2008-08-01 00:00:00

abstract：:Sporulation in Saccharomyces cerevisiae normally occurs only in MATa/MAT alpha diploids. We show that mutations in RME1 bypassed the requirements for both a and alpha mating type information in sporulation and therefore allowed MATa/MATa and MAT alpha/MAT alpha diploids to sporulate. RME1 was located on chromosome VII...

journal_title：Molecular and cellular biology

authors： Rine J,Sprague GF Jr,Herskowitz I

更新日期：1981-10-01 00:00:00

abstract：:Autosomal dominant polycystic kidney disease (ADPKD) constitutes the most inherited kidney disease. Mutations in the PKD1 and PKD2 genes, encoding the polycystin 1 and polycystin 2 Ca2+ ion channels, respectively, result in tubular epithelial cell-derived renal cysts. Recent clinical studies demonstrate oxidative stre...

journal_title：Molecular and cellular biology

authors： Ishimoto Y,Inagi R,Yoshihara D,Kugita M,Nagao S,Shimizu A,Takeda N,Wake M,Honda K,Zhou J,Nangaku M

更新日期：2017-11-28 00:00:00

abstract：:Stage-specific transcriptional programs are an integral feature of cell cycle regulation. In the budding yeast Saccharomyces cerevisiae, over 120 genes are coordinately induced in late G(1) phase by two heterodimeric transcription factors called SBF and MBF. Activation of SBF and MBF is an upstream initiator of key ce...

journal_title：Molecular and cellular biology

authors： Costanzo M,Schub O,Andrews B

更新日期：2003-07-01 00:00:00

abstract：:With the murine retinoblastoma (RB) cDNA, a series of RB mutants were expressed in COS-1 cells and the pRB products were assessed for their ability (i) to bind to large T antigen (large T), (ii) to become modified by phosphorylation, and (iii) to localize in the nucleus. All point mutations and deletions introduced in...

journal_title：Molecular and cellular biology

authors： Hamel PA,Cohen BL,Sorce LM,Gallie BL,Phillips RA

更新日期：1990-12-01 00:00:00

abstract：:The Ace2p and Swi5p zinc finger proteins have nearly identical DNA-binding domains, yet in vivo they activate transcription of different genes, CTS1 and HO. We now demonstrate that Ace2p and Swi5p recognize sites in the CTS1 and HO promoters with the same affinities, raising the question of how promoter specificity is...

journal_title：Molecular and cellular biology

authors： Dohrmann PR,Voth WP,Stillman DJ

更新日期：1996-04-01 00:00:00

abstract：:A transcriptional initiator (Inr) for mammalian RNA polymerase II can be defined as a DNA sequence element that overlaps a transcription start site and is sufficient for (i) determining the start site location in a promoter that lacks a TATA box and (ii) enhancing the strength of a promoter that contains a TATA box. W...

journal_title：Molecular and cellular biology

authors： Javahery R,Khachi A,Lo K,Zenzie-Gregory B,Smale ST

更新日期：1994-01-01 00:00:00

abstract：:Saccharomyces cerevisiae contains several prion elements, which are epigenetically transmitted as self-perpetuating protein conformations. One such prion is [SWI + ], whose protein determinant is Swi1, a subunit of the SWI/SNF chromatin-remodeling complex. We previously rep...

journal_title：Molecular and cellular biology

authors： Valtierra S,Du Z,Li L

更新日期：2017-09-26 00:00:00

abstract：:In Saccharomyces cerevisiae, the protein phosphatase type 1 (PP1)-binding protein Reg1 is required to maintain complete repression of ADH2 expression during growth on glucose. Surprisingly, however, mutant forms of the yeast PP1 homologue Glc7, which are unable to repress expression of another glucose-regulated gene, ...

journal_title：Molecular and cellular biology

authors： Dombek KM,Voronkova V,Raney A,Young ET

更新日期：1999-09-01 00:00:00

abstract：:Mice lacking neuroD2, a basic helix-loop-helix transcription factor involved in brain development, show growth retardation and other abnormalities consistent with hypothalamic-pituitary-thyroid (HPT) axis dysfunction. neuroD2 is expressed in the paraventricular hypothalamic nuclei, the anterior lobe of pituitary, and ...

journal_title：Molecular and cellular biology

authors： Lin CH,Tapscott SJ,Olson JM

更新日期：2006-06-01 00:00:00

abstract：:During mammalian vascular development, endothelial cells form a complex array of vessels that differ markedly in structure and function, but the molecular basis for this vascular complexity is poorly understood. Recent insights into endothelial diversity have come from the identification of molecular markers expressed...

journal_title：Molecular and cellular biology

authors： Xu B,deWaal RM,Mor-Vaknin N,Hibbard C,Markovitz DM,Kahn ML

更新日期：2004-10-01 00:00:00

abstract：:Interleukin-6 (IL-6) and leukemia inhibitory factor (LIF), two multifunctional cytokines, recently have been identified as physiological inducers of hematopoietic cell differentiation which also induce terminal differentiation and growth arrest of the myeloblastic leukemic M1 cell line. In this work, it is shown that ...

journal_title：Molecular and cellular biology

authors： Hoffman-Liebermann B,Liebermann DA

更新日期：1991-05-01 00:00:00

abstract：:The Drosophila dopa decarboxylase gene, Ddc, is expressed in the hypoderm and in a small number of cells in the central nervous system (CNS). The unique Ddc primary transcript is alternatively spliced in these two tissues. We investigated whether Ddc splicing in the CNS is a general property of the CNS or a unique pro...

journal_title：Molecular and cellular biology

authors： Shen J,Beall CJ,Hirsh J

更新日期：1993-08-01 00:00:00

abstract：:RNA interference (RNAi) in animals, cosuppression in plants, and quelling in fungi are homology-dependent gene silencing mechanisms in which the introduction of either double-stranded RNA (dsRNA) or transgenes induces sequence-specific mRNA degradation. These phenomena share a common genetic and mechanistic basis. The...

journal_title：Molecular and cellular biology

authors： Catalanotto C,Pallotta M,ReFalo P,Sachs MS,Vayssie L,Macino G,Cogoni C

更新日期：2004-03-01 00:00:00

abstract：:The protein kinase Akt plays a critical role in heart function and is activated by phosphorylation of threonine 308 (T308) and serine 473 (S473). While phosphoinositide-dependent kinase 1 (PDK1) is responsible for Akt T308 phosphorylation, the identities of the kinases for Akt S473 phosphorylation in the heart remain ...

journal_title：Molecular and cellular biology

authors： Zhao X,Lu S,Nie J,Hu X,Luo W,Wu X,Liu H,Feng Q,Chang Z,Liu Y,Cao Y,Sun H,Li X,Hu Y,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:The Capn5 gene was inactivated by homologous recombination in ES cells that subsequently colonized the germ line of mice. The targeted mutation integrated a lacZ expression cassette into the Capn5 gene, allowing the expression of Capn5 mRNA to be examined in detail in heterozygous animals. Expression was observed in e...

journal_title：Molecular and cellular biology

authors： Franz T,Winckler L,Boehm T,Dear TN

更新日期：2004-02-01 00:00:00

abstract：:Hypoxia promotes stem cell maintenance and tumor progression, but it remains unclear how it regulates long-term adaptation toward these processes. We reveal a striking downregulation of the hypoxia-inducible histone H3 lysine 9 (H3K9) demethylase JMJD1A as a hallmark of clinical human germ cell-derived tumors, such as...

journal_title：Molecular and cellular biology

authors： Ueda J,Ho JC,Lee KL,Kitajima S,Yang H,Sun W,Fukuhara N,Zaiden N,Chan SL,Tachibana M,Shinkai Y,Kato H,Poellinger L

更新日期：2014-10-01 00:00:00

abstract：:Welander distal myopathy (WDM) is a muscle dystrophy characterized by adult-onset distal muscle weakness, prevalently impacting the distal long extensors of the hands and feet. WDM is an autosomal dominant disorder caused by a missense mutation (c.1362G>A; p.E384K) in the TIA1 (T-cell intracellular antigen 1) gene, wh...

journal_title：Molecular and cellular biology

authors： Carrascoso I,Sánchez-Jiménez C,Silion E,Alcalde J,Izquierdo JM

更新日期：2018-12-11 00:00:00

abstract：:The product of the EUG1 gene of Saccharomyces cerevisiae is a soluble endoplasmic reticulum protein with homology to both the mammalian protein disulfide isomerase (PDI) and the yeast PDI homolog encoded by the essential PDI1 gene. Deletion or overexpression of EUG1 causes no growth defects under a variety of conditio...

journal_title：Molecular and cellular biology

authors： Tachibana C,Stevens TH

更新日期：1992-10-01 00:00:00

abstract：:Cytoplasmic poly(A) elongation is one mechanism that regulates translational recruitment of maternal mRNA in early development. In Xenopus laevis, poly(A) elongation is controlled by two cis elements in the 3' untranslated regions of responsive mRNAs: the hexanucleotide AAUAAA and a U-rich structure with the general s...

journal_title：Molecular and cellular biology

authors： Stebbins-Boaz B,Richter JD

更新日期：1994-09-01 00:00:00

abstract：:The niaD and niiA genes of Aspergillus nidulans, which code, respectively, for nitrate and nitrite reductases, are divergently transcribed, and their ATGs are separated by 1,200 bp. The genes are under the control of the positively acting NirA transcription factor, which mediates nitrate induction. The DNA binding dom...

journal_title：Molecular and cellular biology

authors： Punt PJ,Strauss J,Smit R,Kinghorn JR,van den Hondel CA,Scazzocchio C

更新日期：1995-10-01 00:00:00

abstract：:When exposed to 5-azacytidine, marrow stromal cells from active long-term marrow cultures and cell lines derived from simian virus 40-transformed stromal cells rapidly upregulated c-abl and interleukin-6 transcripts while downregulating the expression of collagen I, a major matrix protein. Similar effects occurred wit...

journal_title：Molecular and cellular biology

authors： Andrews DF 3rd,Nemunaitis J,Tompkins C,Singer JW

更新日期：1989-06-01 00:00:00

abstract：:PC12 cells treated with nerve growth factor (NGF) or infected with Rous sarcoma virus differentiate into sympathetic, neuronlike cells. To compare the differentiation programs induced by NGF and v-src, we have established a PC12 cell line expressing a temperature-sensitive v-src protein. The v-src-expressing PC12 cell...

journal_title：Molecular and cellular biology

authors： Thomas SM,Hayes M,D'Arcangelo G,Armstrong RC,Meyer BE,Zilberstein A,Brugge JS,Halegoua S

更新日期：1991-09-01 00:00:00

abstract：:The relationship between chromatin remodeling and histone acetylation at the yeast CUP1 gene was addressed. CUP1 encodes a metallothionein required for cell growth at high copper concentrations. Induction of CUP1 with copper resulted in targeted acetylation of both H3 and H4 at the CUP1 promoter. Nucleosomes containin...

journal_title：Molecular and cellular biology

authors： Shen CH,Leblanc BP,Neal C,Akhavan R,Clark DJ

更新日期：2002-09-01 00:00:00

abstract：:Using several actin isotype-specific cDNA probes, we found actin mRNA of two size classes, 2.1 and 1.5 kilobases (kb), in extracts of polyadenylated and nonpolyadenylated RNA from sexually mature CD-1 mouse testes. Although the 2.1-kb sequence was present in both meiotic and postmeiotic testicular cell types, it decre...

journal_title：Molecular and cellular biology

authors： Waters SH,Distel RJ,Hecht NB

更新日期：1985-07-01 00:00:00