Abstract:
:Mice lacking neuroD2, a basic helix-loop-helix transcription factor involved in brain development, show growth retardation and other abnormalities consistent with hypothalamic-pituitary-thyroid (HPT) axis dysfunction. neuroD2 is expressed in the paraventricular hypothalamic nuclei, the anterior lobe of pituitary, and the thyroid gland. In neuroD2-deficient mice, thyrotropin-releasing hormone, thyroid-stimulating hormone, and thyroid hormone are decreased in these three regions, respectively. neuroD2-null mice typically die 2 to 3 weeks after birth, but those treated with replacement doses of thyroxine survived more than 8 weeks. These data indicate that neuroD2 is expressed throughout the HPT axis and that all levels of the axis are functionally affected by its absence in mice.
journal_name
Mol Cell Bioljournal_title
Molecular and cellular biologyauthors
Lin CH,Tapscott SJ,Olson JMdoi
10.1128/MCB.02158-05subject
Has Abstractpub_date
2006-06-01 00:00:00pages
4311-5issue
11eissn
0270-7306issn
1098-5549pii
26/11/4311journal_volume
26pub_type
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