One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs.

abstract：:PC12 cells treated with nerve growth factor (NGF) or infected with Rous sarcoma virus differentiate into sympathetic, neuronlike cells. To compare the differentiation programs induced by NGF and v-src, we have established a PC12 cell line expressing a temperature-sensitive v-src protein. The v-src-expressing PC12 cell...

journal_title：Molecular and cellular biology

authors： Thomas SM,Hayes M,D'Arcangelo G,Armstrong RC,Meyer BE,Zilberstein A,Brugge JS,Halegoua S

更新日期：1991-09-01 00:00:00

abstract：:The numerous members of the steroid/nuclear hormone receptor superfamily act as direct transducers of circulating signals, such as steroids, thyroid hormone, and vitamin or lipid metabolites, and modulate the transcription of specific target genes, primarily as dimeric complexes. The receptors for 9-cis retinoic acid ...

journal_title：Molecular and cellular biology

authors： Lemon BD,Fondell JD,Freedman LP

更新日期：1997-04-01 00:00:00

abstract：:B52, an essential SR protein of Drosophila melanogaster, stimulates pre-mRNA splicing in splicing-deficient mammalian S100 extracts. Surprisingly, mutant larvae depleted of B52 were found to be capable of splicing at least several pre-mRNAs tested (H. Z. Ring and J. T. Lis, Mol. Cell. Biol. 14:7499-7506, 1994). In a h...

journal_title：Molecular and cellular biology

authors： Hoffman BE,Lis JT

更新日期：2000-01-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell proliferation, cell differentiation, and cell migration. Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 (AP-1). Integrin-linked kinas...

journal_title：Molecular and cellular biology

authors： Troussard AA,Tan C,Yoganathan TN,Dedhar S

更新日期：1999-11-01 00:00:00

abstract：:We have isolated new histone H3 mutants in Saccharomyces cerevisiae that confer phenotypes indicative of transcriptional defects. Here we describe the characterization of one such mutant, encoded by the hht2-11 allele, which contains the single amino acid change L61W in the globular domain of H3. Whole-genome expressi...

journal_title：Molecular and cellular biology

authors： Duina AA,Winston F

更新日期：2004-01-01 00:00:00

abstract：:The mSin3A-histone deacetylase corepressor is a multiprotein complex that is recruited by DNA binding transcriptional repressors. Sin3 has four paired amphipathic alpha helices (PAH1 to -4) that are protein-protein interaction motifs and is the scaffold upon which the complex assembles. We identified a novel mSin3A-in...

journal_title：Molecular and cellular biology

authors： Yochum GS,Ayer DE

更新日期：2001-07-01 00:00:00

abstract：:The cytokine gamma interferon (IFN-gamma) and the calcitropic steroid hormone 1,25-dihydroxyvitamin D (1,25D) are activators of macrophage immune function. In sarcoidosis, tuberculosis, and several granulomatoses, IFN-gamma induces 1,25D synthesis by macrophages and inhibits 1,25D induction of 24-hydroxylase, a key en...

journal_title：Molecular and cellular biology

authors： Vidal M,Ramana CV,Dusso AS

更新日期：2002-04-01 00:00:00

abstract：:Synonymous single nucleotide polymorphisms (SNPs) within a transcript's coding region produce no change in the amino acid sequence of the protein product and are therefore intuitively assumed to have a neutral effect on protein function. We report that two common variants of high-temperature requirement A1 (HTRA1) tha...

journal_title：Molecular and cellular biology

authors： Jacobo SM,Deangelis MM,Kim IK,Kazlauskas A

更新日期：2013-05-01 00:00:00

abstract：:Saccharomyces cerevisiae mating type switching is a gene conversion event that exhibits donor preference. MATa cells choose HMLalpha for recombination, and MATalpha cells choose HMRa. Donor preference is controlled by the recombination enhancer (RE), located between HMLalpha and MATa on the left arm of chromosome III....

journal_title：Molecular and cellular biology

authors： Ercan S,Reese JC,Workman JL,Simpson RT

更新日期：2005-09-01 00:00:00

abstract：:The FLP protein of the Saccharomyces cerevisiae plasmid 2 microns circle catalyzes site-specific recombination between two repeated segments present on the plasmid. In this paper we present results of experiments we performed to define more precisely the features of the FLP recognition target site, which we propose to...

journal_title：Molecular and cellular biology

authors： McLeod M,Craft S,Broach JR

更新日期：1986-10-01 00:00:00

abstract：:E2F and RB proteins regulate the expression of genes involved in cell cycle progression, apoptosis, differentiation, and development. Recent studies indicate that they function as part of an evolutionarily conserved multiprotein complex termed dREAM/DREAM/LINC. Here we characterize the role of the Drosophila complex, ...

journal_title：Molecular and cellular biology

authors： Lee H,Ragusano L,Martinez A,Gill J,Dimova DK

更新日期：2012-06-01 00:00:00

abstract：:Previous characterization of GLI, a gene found to be amplified and expressed in a subset of human brain tumors, revealed the presence of five tandem zinc fingers related to those of Krüppel (Kr), a Drosophila segmentation gene of the gap class. We have used the GLI cDNA as a molecular probe to isolate related sequence...

journal_title：Molecular and cellular biology

authors： Ruppert JM,Kinzler KW,Wong AJ,Bigner SH,Kao FT,Law ML,Seuanez HN,O'Brien SJ,Vogelstein B

更新日期：1988-08-01 00:00:00

abstract：:The product of the retinoblastoma susceptibility gene, pRB, is a nuclear phosphoprotein that controls cell growth by binding to and suppressing the activities of transcription factors such as the E2F family. Transactivation activity is inhibited when E2F is bound to hypophosphorylated pRB and released when pRB is phos...

journal_title：Molecular and cellular biology

authors： Brown VD,Phillips RA,Gallie BL

更新日期：1999-05-01 00:00:00

abstract：:We have examined the possible role of adenosine 3',5'-phosphate (cAMP) in functions associated with the plasma membranes of Saccharomyces cerevisiae. Purified membranes from this source contained an adenylate cyclase which was insensitive to activation by fluoride or guanine nucleotides, only weakly responsive to chan...

journal_title：Molecular and cellular biology

authors： Jaynes PK,McDonough JP,Mahler HR

更新日期：1982-12-01 00:00:00

abstract：:We provide evidence that human SLFN5, an interferon (IFN)-inducible member of the Schlafen (SLFN) family of proteins, exhibits key roles in controlling motility and invasiveness of renal cell carcinoma (RCC) cells. Our studies define the mechanism by which this occurs, demonstrating that SLFN5 negatively controls expr...

journal_title：Molecular and cellular biology

authors： Sassano A,Mavrommatis E,Arslan AD,Kroczynska B,Beauchamp EM,Khuon S,Chew TL,Green KJ,Munshi HG,Verma AK,Platanias LC

更新日期：2015-08-01 00:00:00

abstract：:During mammalian vascular development, endothelial cells form a complex array of vessels that differ markedly in structure and function, but the molecular basis for this vascular complexity is poorly understood. Recent insights into endothelial diversity have come from the identification of molecular markers expressed...

journal_title：Molecular and cellular biology

authors： Xu B,deWaal RM,Mor-Vaknin N,Hibbard C,Markovitz DM,Kahn ML

更新日期：2004-10-01 00:00:00

abstract：:The estrogen receptor (ER) modulates transcription by forming complexes with other proteins and then binding to the estrogen response element (ERE). We have identified a novel interaction of this receptor with the POU transcription factors Brn-3a and Brn-3b which was independent of ligand binding. By pull-down assays ...

journal_title：Molecular and cellular biology

authors： Budhram-Mahadeo V,Parker M,Latchman DS

更新日期：1998-02-01 00:00:00

abstract：:Saccharomyces mating-type switching occurs through a double-strand break-initiated gene conversion event at MAT, using one of two donors located distantly on the same chromosome, HMLalpha and HMRa. MATa cells preferentially choose HMLalpha, a decision that depends on the recombination enhancer (RE) that controls recom...

journal_title：Molecular and cellular biology

authors： Coïc E,Sun K,Wu C,Haber JE

更新日期：2006-07-01 00:00:00

abstract：:p53 promotes apoptosis in response to death stimuli by transactivation of target genes and by transcription-independent mechanisms. We recently showed that wild-type p53 rapidly translocates to mitochondria in response to multiple death stimuli in cultured cells. Mitochondrial p53 physically interacts with antiapoptot...

journal_title：Molecular and cellular biology

authors： Erster S,Mihara M,Kim RH,Petrenko O,Moll UM

更新日期：2004-08-01 00:00:00

abstract：:Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these no...

journal_title：Molecular and cellular biology

authors： Kulshreshtha R,Ferracin M,Wojcik SE,Garzon R,Alder H,Agosto-Perez FJ,Davuluri R,Liu CG,Croce CM,Negrini M,Calin GA,Ivan M

更新日期：2007-03-01 00:00:00

abstract：:White adipose tissue (WAT) serves as a reversible energy storage depot in the form of lipids in response to nutritional status. Cavin-1, an essential component in the biogenesis of caveolae, is a positive regulator of lipolysis in adipocytes. However, molecular mechanisms of cavin-1 in the modulation of lipolysis rema...

journal_title：Molecular and cellular biology

authors： Zhou SR,Guo L,Wang X,Liu Y,Peng WQ,Liu Y,Wei XB,Dou X,Ding M,Lei QY,Qian SW,Li X,Tang QQ

更新日期：2017-07-28 00:00:00

abstract：:The members of the Sp1 transcription factor family can act as both negative and positive regulators of gene expression. Here we show that Sp1 can be a target for histone deacetylase 1 (HDAC1)-mediated transcriptional repression. The histone deacetylase inhibitor trichostatin A activates the chromosomally integrated mu...

journal_title：Molecular and cellular biology

authors： Doetzlhofer A,Rotheneder H,Lagger G,Koranda M,Kurtev V,Brosch G,Wintersberger E,Seiser C

更新日期：1999-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae RAD18 gene is essential for postreplication repair but is not required for homologous recombination (HR), which is the major double-strand break (DSB) repair pathway in yeast. Accordingly, yeast rad18 mutants are tolerant of camptothecin (CPT), a topoisomerase I inhibitor, which induces DS...

journal_title：Molecular and cellular biology

authors： Saberi A,Hochegger H,Szuts D,Lan L,Yasui A,Sale JE,Taniguchi Y,Murakawa Y,Zeng W,Yokomori K,Helleday T,Teraoka H,Arakawa H,Buerstedde JM,Takeda S

更新日期：2007-04-01 00:00:00

abstract：:Drosophila sine oculis and eyes absent genes synergize in compound-eye formation. The murine homologues of these genes, Six and Eya, respectively, show overlapping expression patterns during development. We hypothesized that Six and Eya proteins cooperate to regulate their target genes. Cotransfection assays were perf...

journal_title：Molecular and cellular biology

authors： Ohto H,Kamada S,Tago K,Tominaga SI,Ozaki H,Sato S,Kawakami K

更新日期：1999-10-01 00:00:00

abstract：:The liver-enriched transcription factor C/EBP alpha has been implicated in the regulation of numerous liver-specific genes. It was previously reported that mice carrying a homozygous null mutation at the c/ebp alpha locus died as neonates due to the absence of hepatic glycogen and the resulting hypoglycemia. However, ...

journal_title：Molecular and cellular biology

authors： Lee YH,Sauer B,Johnson PF,Gonzalez FJ

更新日期：1997-10-01 00:00:00

abstract：:The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely resc...

journal_title：Molecular and cellular biology

authors： Grier JD,Xiong S,Elizondo-Fraire AC,Parant JM,Lozano G

更新日期：2006-01-01 00:00:00

abstract：:The alpha-myosin heavy-chain (alpha-MHC) gene is the major structural protein in the adult rodent myocardium. Its expression is restricted to the heart by a complex interplay of trans-acting factors and their cis-acting sites. However, to date, the factors that have been shown to regulate expression of this gene have ...

journal_title：Molecular and cellular biology

authors： Molkentin JD,Kalvakolanu DV,Markham BE

更新日期：1994-07-01 00:00:00

abstract：:The role of chromatin-remodeling factors in transcription is well established, but the link between chromatin-remodeling complexes and DNA repair remains unexplored. Human Rvb1 and Rvb2 are highly conserved AAA(+) ATP binding proteins that are part of various chromatin-remodeling complexes, such as Ino80, SNF2-related...

journal_title：Molecular and cellular biology

authors： Jha S,Shibata E,Dutta A

更新日期：2008-04-01 00:00:00

abstract：:In the accompanying report (C. F. Webb, C. Das, S. Eaton, K. Calame, and P. Tucker, Mol. Cell. Biol. 11:5197-5205, 1991), we characterize B-cell-specific protein-DNA interactions at -500 and -200 bp upstream of the mu immunoglobulin heavy chain promoter whose abundances were increased by interleukin-5 plus antigen. Be...

journal_title：Molecular and cellular biology

authors： Webb CF,Das C,Eneff KL,Tucker PW

更新日期：1991-10-01 00:00:00

abstract：:Intestinal gene regulation involves mechanisms that direct temporal expression along the vertical and horizontal axes of the alimentary tract. Sucrase-isomaltase (SI), the product of an enterocyte-specific gene, exhibits a complex pattern of expression. Generation of transgenic mice with a mutated SI transgene showed ...

journal_title：Molecular and cellular biology

authors： Boudreau F,Rings EH,Swain GP,Sinclair AM,Suh ER,Silberg DG,Scheuermann RH,Traber PG

更新日期：2002-08-01 00:00:00