Human Schlafen 5 (SLFN5) Is a Regulator of Motility and Invasiveness of Renal Cell Carcinoma Cells.

abstract：:Here, we demonstrate that SENP2, a desumoylating enzyme, plays a critical role in the control of adipogenesis. SENP2 expression was markedly increased upon the induction of adipocyte differentiation, and this increase was dependent on protein kinase A activation. Remarkably, knockdown of SENP2 led to a dramatic attenu...

journal_title：Molecular and cellular biology

authors： Chung SS,Ahn BY,Kim M,Choi HH,Park HS,Kang S,Park SG,Kim YB,Cho YM,Lee HK,Chung CH,Park KS

更新日期：2010-05-01 00:00:00

abstract：:SCF complexes are E3 ubiquitin-protein ligases that mediate degradation of regulatory and signaling proteins and control G1/S cell cycle progression by degradation of G1 cyclins and the cyclin-dependent kinase inhibitor, Sic1. Interchangeable F-box proteins bind the core SCF components; each recruits a specific subset...

journal_title：Molecular and cellular biology

authors： Ivantsiv Y,Kaplun L,Tzirkin-Goldin R,Shabek N,Raveh D

更新日期：2006-03-01 00:00:00

abstract：:In vitro experiments with cell extracts prepared from a mouse mammary epithelial cell line demonstrated that a cis-acting glucocorticoid response element (GRE) of the mouse mammary tumor virus represses transcription from its homologous promoter. Competition transcription experiments, in which a molar excess of a rest...

journal_title：Molecular and cellular biology

authors： Langer SJ,Ostrowski MC

更新日期：1988-09-01 00:00:00

abstract：:Saccharomyces mating-type switching occurs through a double-strand break-initiated gene conversion event at MAT, using one of two donors located distantly on the same chromosome, HMLalpha and HMRa. MATa cells preferentially choose HMLalpha, a decision that depends on the recombination enhancer (RE) that controls recom...

journal_title：Molecular and cellular biology

authors： Coïc E,Sun K,Wu C,Haber JE

更新日期：2006-07-01 00:00:00

abstract：:Gap junctions are membrane channels that permit the interchange of ions and other low-molecular-weight molecules between adjacent cells. Rous sarcoma virus (RSV)-induced transformation is marked by an early and profound disruption of gap-junctional communication, suggesting that these membrane structures may serve as ...

journal_title：Molecular and cellular biology

authors： Crow DS,Beyer EC,Paul DL,Kobe SS,Lau AF

更新日期：1990-04-01 00:00:00

abstract：:The c-Myc oncoprotein (Myc) controls cell fate by regulating gene transcription in association with a DNA-binding partner, Max. While Max lacks a transcription regulatory domain, the N terminus of Myc contains a transcription activation domain (TAD) that recruits cofactor complexes containing the histone acetyltransfe...

journal_title：Molecular and cellular biology

authors： Faiola F,Liu X,Lo S,Pan S,Zhang K,Lymar E,Farina A,Martinez E

更新日期：2005-12-01 00:00:00

abstract：:A mouse adenine phosphoribosyltransferase (aprt) pseudogene that had previously been recovered from a BALB/c sperm DNA library possessed several unusual features. Its nucleotide sequence, like that of other processed pseudogenes, was colinear with its corresponding mRNA, but it was truncated at its 3' end and lacked a...

journal_title：Molecular and cellular biology

authors： Dush MK,Tischfield JA,Khan SA,Feliciano E,Sikela JM,Kozak CA,Stambrook PJ

更新日期：1986-12-01 00:00:00

abstract：:O(6)-Methylguanine (m6G) is formed by the action of alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) on DNA. m6G is a highly mutagenic and carcinogenic lesion, and it presents a block to synthesis by DNA polymerases. Here, we provide genetic and biochemical evidence for the involvement of yeast an...

journal_title：Molecular and cellular biology

authors： Haracska L,Prakash S,Prakash L

更新日期：2000-11-01 00:00:00

abstract：:Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression is poorly understood. Here, we report that a major target of H1-mediated regulation in embryonic stem (ES) cells is the X-linked Rhox homeobox gene cluster. To address the underlying mechanism, we examined t...

journal_title：Molecular and cellular biology

authors： Maclean JA,Bettegowda A,Kim BJ,Lou CH,Yang SM,Bhardwaj A,Shanker S,Hu Z,Fan Y,Eckardt S,McLaughlin KJ,Skoultchi AI,Wilkinson MF

更新日期：2011-03-01 00:00:00

abstract：:Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and repair. Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzymes that catalyze deoxyribonucleoside diphosphate (dNDP) synthesis. We ...

journal_title：Molecular and cellular biology

authors： Sanvisens N,Romero AM,An X,Zhang C,de Llanos R,Martínez-Pastor MT,Bañó MC,Huang M,Puig S

更新日期：2014-09-01 00:00:00

abstract：:The RGT1 gene of Saccharomyces cerevisiae plays a central role in the glucose-induced expression of hexose transporter (HXT) genes. Genetic evidence suggests that it encodes a repressor of the HXT genes whose function is inhibited by glucose. Here, we report the isolation of RGT1 and demonstrate that it encodes a bifu...

journal_title：Molecular and cellular biology

authors： Ozcan S,Leong T,Johnston M

更新日期：1996-11-01 00:00:00

abstract：:Ribosomes can be programmed to shift from one reading frame to another during translation. Hepatitis C virus (HCV) uses such a mechanism to produce F protein from the -2/+1 reading frame. We now report that the HCV frameshift signal can mediate the synthesis of the core protein of the zero frame, the F protein of the ...

journal_title：Molecular and cellular biology

authors： Choi J,Xu Z,Ou JH

更新日期：2003-03-01 00:00:00

abstract：:The human Ki-ras gene was previously reported to contain two alternative fourth exons which encode two distinct p21 proteins differing only at their carboxy termini. The present study shows that either p21 protein is able on its own to transform NIH 3T3 cells to a tumorigenic state. ...

journal_title：Molecular and cellular biology

authors： McCoy MS,Weinberg RA

更新日期：1986-04-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) Tat protein activates transcription elongation by stimulating the Tat-activated kinase (TAK/p-TEFb), a protein kinase composed of CDK9 and its cyclin partner, cyclin T1. CDK9 is able to hyperphosphorylate the carboxyl-terminal domain (CTD) of the large subunit of RNA pol...

journal_title：Molecular and cellular biology

authors： Bourgeois CF,Kim YK,Churcher MJ,West MJ,Karn J

更新日期：2002-02-01 00:00:00

abstract：:One of the central questions in eukaryotic transcription is how activators can transmit their signal to stimulate gene expression in the context of chromatin. The multisubunit SAGA coactivator complex has both histone acetyltransferase and deubiquitination activities and remodels chromatin to allow transcription. Whet...

journal_title：Molecular and cellular biology

authors： Nagy Z,Riss A,Romier C,le Guezennec X,Dongre AR,Orpinell M,Han J,Stunnenberg H,Tora L

更新日期：2009-03-01 00:00:00

abstract：:The nucleotide sequence of 5'-noncoding and N-terminal coding regions of two coordinately regulated, repressible acid phosphatase genes from Saccharomyces cerevisiae were determined. These unlinked genes encode different, but structurally related polypeptides of molecular weights 60,000 and 56,000. The DNA sequences o...

journal_title：Molecular and cellular biology

authors： Thill GP,Kramer RA,Turner KJ,Bostian KA

更新日期：1983-04-01 00:00:00

abstract：:The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular processes. Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is a prototypic target of the UPP and, as such, is stabilized under conditions of proteasomal inhibition. Using carbonic anhydrase IX (CAIX) and vascular endothelial growth fa...

journal_title：Molecular and cellular biology

authors： Kaluz S,Kaluzová M,Stanbridge EJ

更新日期：2006-08-01 00:00:00

abstract：:Spermatogonial stem cells (SSCs) are unipotent germ cells that are at the foundation of spermatogenesis and male fertility. However, the underlying molecular mechanisms governing SSC stemness and growth properties remain elusive. We have recently identified chromodomain helicase/ATPase DNA binding protein 1-like (Chd1...

journal_title：Molecular and cellular biology

authors： Liu SS,Maguire EM,Bai YS,Huang L,Liu Y,Xu L,Fauzi I,Zhang SQ,Xiao Q,Ma NF

更新日期：2019-02-04 00:00:00

abstract：:SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes in the T-cell lineage. SATB1 binds to the bases of chromatin loop domains in vivo, recognizing a special DNA context with strong base-unpairing propensity. The majority of thymocytes are eliminated by...

journal_title：Molecular and cellular biology

authors： Galande S,Dickinson LA,Mian IS,Sikorska M,Kohwi-Shigematsu T

更新日期：2001-08-01 00:00:00

abstract：:Mutations induced by UVB (313-nm) radiation, a wavelength in the region of peak effectiveness for sunlight-induced skin cancer in humans, have been analyzed at the sequence level in simian cells by using a plasmid shuttle vector (pZ189). We find that significant differences exist between the types of mutations induced...

journal_title：Molecular and cellular biology

authors： Keyse SM,Amaudruz F,Tyrrell RM

更新日期：1988-12-01 00:00:00

abstract：:In self-fertile strains of the fission yeast Schizosaccharomyces pombe, nitrogen starvation initiates a program of sexual development in which cells express mating pheromones and receptors, arrest cell cycle progression in G1, and conjugate. This process is dependent on Rum1, an inhibitor of the Cdc2-Cdc13 and Cdc2-Ci...

journal_title：Molecular and cellular biology

authors： Wu L,Russell P

更新日期：1997-01-01 00:00:00

abstract：:Major histocompatibility complex class II (MHCII) molecules play a pivotal role in the immune system because they direct the development and activation of CD4(+) T cells. There are three human MHCII isotypes, HLA-DR, HLA-DQ, and HLA-DP. Key transcription factors controlling MHCII genes have been identified by virtue o...

journal_title：Molecular and cellular biology

authors： Peretti M,Villard J,Barras E,Zufferey M,Reith W

更新日期：2001-09-01 00:00:00

abstract：:Mammalian MEK1 and MEK2 contain a proline-rich (PR) sequence that is absent both from the yeast homologs Ste7 and Byr1 and from a recently cloned activator of the JNK/stress-activated protein kinases, SEK1/MKK4. Since this PR sequence occurs in MEKs that are regulated by Raf family enzymes but is missing from MEKs and...

journal_title：Molecular and cellular biology

authors： Catling AD,Schaeffer HJ,Reuter CW,Reddy GR,Weber MJ

更新日期：1995-10-01 00:00:00

abstract：:Eukaryotic elongation factor 1 alpha 2 (eEF1A2) is a transforming gene product that is highly expressed in human tumors of the ovary, lung, and breast. eEF1A2 also stimulates actin remodeling, and the expression of this factor is sufficient to induce the formation of filopodia, long cellular processes composed of bund...

journal_title：Molecular and cellular biology

authors： Jeganathan S,Morrow A,Amiri A,Lee JM

更新日期：2008-07-01 00:00:00

abstract：:Sequence blocks within the core region were swapped among RNA polymerase II promoters to explore effects on transcription in vitro. The pair of blocks flanking TATA strongly influenced general transcription, with an additional effect on promoter activation. These flanking elements induced a change in the ratio of acti...

journal_title：Molecular and cellular biology

authors： Wolner BS,Gralla JD

更新日期：2000-05-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell proliferation, cell differentiation, and cell migration. Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 (AP-1). Integrin-linked kinas...

journal_title：Molecular and cellular biology

authors： Troussard AA,Tan C,Yoganathan TN,Dedhar S

更新日期：1999-11-01 00:00:00

abstract：:The int-1 proto-oncogene is a target for insertional activation of transcription by mouse mammary tumor virus in many murine mammary tumors. Whereas no expression of int-1 is seen in normal mammary tissue, int-1 RNA can be detected in normal mice in the neural tubes of midgestation embryos and in postmeiotic spermatoc...

journal_title：Molecular and cellular biology

authors： Papkoff J

更新日期：1989-08-01 00:00:00

abstract：:Monoclonal antibodies to fibrillin 1 (MP340), a component of elastin-associated microfibrils, were used to screen cDNA libraries made from bovine nuchal ligament mRNA. One of the selected clones (cL9; 1.2 kb) hybridized on Northern (RNA) blotting with nuchal ligament mRNA to two abundant mRNAs of 9.0 and 7.5 kb, which...

journal_title：Molecular and cellular biology

authors： Gibson MA,Hatzinikolas G,Davis EC,Baker E,Sutherland GR,Mecham RP

更新日期：1995-12-01 00:00:00

abstract：:USF is a family of basic helix-loop transcriptional factors that recognizes DNA-binding sites similar to those of the Myc oncoproteins. Here, various functional domains in the mouse USF2 protein were identified and characterized. Indirect immunofluorescence studies with transiently transfected cells revealed that both...

journal_title：Molecular and cellular biology

authors： Luo X,Sawadogo M

更新日期：1996-04-01 00:00:00

abstract：:We have studied intrachromosomal gene conversion in mouse Ltk- cells with a substrate designed to provide genetic evidence for heteroduplex DNA. Our recombination substrate consists of two defective chicken thymidine kinase genes arranged so as to favor the selection of gene conversion products. The gene intended to s...

journal_title：Molecular and cellular biology

authors： Bollag RJ,Elwood DR,Tobin ED,Godwin AR,Liskay RM

更新日期：1992-04-01 00:00:00