Abstract:
PURPOSE:Gap junctions are intercellular contacts important for the synchronization of muscle cell activity through electrical coupling. Since the role of gap junctions for the function of smooth bladder muscle is still a matter of debate, we investigated the occurrence of gap junctions and the gap junctional protein connexin (Cx) 45 in the detrusor of the nonobstructed stable human bladder. MATERIALS AND METHODS:Detrusor biopsies from 6 patients aged 64 (55-72) years with stable nonobstructed bladders were investigated for the occurrence of gap junctions by electron microscopy, molecular biological techniques and immunohistochemistry. RESULTS:Transmission electron microscopy and freeze fracture showed the presence of gap junction at plasma membranes of detrusor smooth muscle cells. By reverse transcriptase (RT) polymerase chain reaction (PCR) and in situ hybridization, we found an expression of Cx45 in the detrusor. These data were confirmed by immunolocalization of Cx45 on smooth muscle cells. CONCLUSIONS:This study provides morphological as well as molecular biological and immunohistochemical evidence that bladder smooth muscle cells are electrically coupled.
journal_name
Aktuelle Uroljournal_title
Aktuelle Urologieauthors
John H,Wang X,Hauri D,Maake Cdoi
10.1055/s-2003-42001subject
Has Abstractpub_date
2003-09-01 00:00:00pages
328-32issue
5eissn
0001-7868issn
1438-8820journal_volume
34pub_type
杂志文章abstract:INTRODUCTION:Ovarian metastases of renal cell cancer (RCC) are extremely rare with less than 20 cases reported to date. These metastases occur in the majority of cases metachronous (i. e. prior to or after identification of the primary tumour) or--such as in our case--synchronous. CASE REPORT:A 42-year-old women was d...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2006-932159
更新日期:2007-01-01 00:00:00
abstract::Unenhanced computed tomography (CT) has a sensitivity of 97.7 to 100 % for the detection of urolithiasis. Using a modified examination protocol, the radiation exposure of a CT examination can be reduced to the level of a single conventional radiographic view of the abdomen (ultra-low-dose CT), assuming the examination...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-2004-830031
更新日期:2004-08-01 00:00:00
abstract::Numerous substances are available for the treatment of metastatic renal cell carcinoma (mRCC). Therefore, medical treatment of patients with mRCC has become a very complex subject. This review summarises clinical studies and typical side-effects of currently available agents that have been approved in Germany. The aut...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0972-0788
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:Hematogenous spread of BCG after intravesical instillation against bladder cancer is rare, but may result in systemic infection and hypersensitivity reaction. We investigated fluoroquinolones and steroids in an animal model to improve the therapeutic options in local and systemic BCG infection. Furthermore, we ...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2004-818541
更新日期:2004-09-01 00:00:00
abstract::Transurethral resection of bladder tumors (TURB) is the cornerstone in urological care of bladder cancer patients. Since the introduction of resectoscopes almost 100 years ago, little has changed in the basic resection technique. The further dissemination of the en-bloc resection (ERBT), which in contrast to fragmente...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-1171-1137
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Testicular trauma can be classified into blunt or penetrating injury. While every case of penetrating trauma is subjected to surgical treatment, the decision between surgery and conservative treatment must be made for each case of blunt injury. Inspection, palpation and duplex sonography may be helpful in ...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-40234
更新日期:2003-05-01 00:00:00
abstract::Faced with the dilemma of choosing between the extremes of standard whole gland therapy and active surveillance, those affected by prostate cancer have recently been on the lookout for less invasive alternatives. Particularly the question of whether it would be possible in low risk cancer to treat only the tumour itse...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1396803
更新日期:2015-01-01 00:00:00
abstract::Urolithiasis is an urologist's daily business. This article provides an overview of the developments in the management of urinary stone disease since the 1970s. While conventional KUB X-rays and intravenous pyelography were standard imaging procedures in the past, computed tomography is the first choice today. Conserv...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0828-9936
更新日期:2019-04-01 00:00:00
abstract:INTRODUCTION:Pasqualini's syndrome is an isolated, incretory functional disorder of the testes with a secondary Leydig cell insufficiency but, unlike Klinefelder's syndrome, with normal spermiogenesis and fertility. This unusual form of hypogonadism is caused by an inherent LH secretion disorder of the pituitary gland....
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2006-932206
更新日期:2007-07-01 00:00:00
abstract::The outpatient forensic aftercare department of the Charité Berlin treated 32 paraphilic sex offenders with GnRH analogues within the past 5 years. Out of those patients, three men suffered from urolithiasis and were in need of treatment. All 3 patients had previously developed osteopenia/osteoporosis while on antiand...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0042-112999
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:In clinical practice the tumour size measured in the histopathological examination of the operative specimen is used both to determine tumour stage. We have investigated the agreement between tumour size determined by preoperative computed tomography (CT) and pathological tumour size. MATERIAL AND METHODS:Betw...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0031-1271392
更新日期:2011-07-01 00:00:00
abstract::At present medical castration employing luteinising hormone releasing hormone (LHRH) agonists is the standard of care for patients with advanced prostate cancer. LHRH agonists suppress the synthesis of testosterone to a castration level. In contrast to surgical castration, medical castration is reversible. However LHR...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0028-1098882
更新日期:2009-05-01 00:00:00
abstract::Osteosarcoma of the prostate is a rare finding. These tumours usually occur years after radiotherapy for prostate cancer. We report the case of a 74-year-old man with prostate cancer who had been treated with radiotherapy and androgen deprivation therapy. The man presented with urinary retention and his prostate was t...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0032-1323744
更新日期:2012-12-01 00:00:00
abstract::The field of urogynaecology represents an interdisciplinary subspecialty which is dedicated to qualified diagnostics and effective treatment of functional, static, endocrine and urological pelvic floor disorders. Core areas of the surgical uro-gynaecology are pelvic floor reconstruction for the treatment of urinary an...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0031-1271571
更新日期:2011-07-01 00:00:00
abstract::Patients with metastatic renal cell carcinoma have a life-limiting prognosis. Therefore, the aim of therapy is normally palliative care. Nevertheless, substantial achievements have been made in the past years. Cytokines as long-term standard therapy have been more and more replaced by new targeted therapies. Sunitinib...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1363228
更新日期:2014-01-01 00:00:00
abstract::The scrotal leiomyoma is a rare benign tumour, deriving from the smooth muscle. This tumour entity constitutes a differential diagnosis to malignant testicular tumours. Up to now, only 8 cases have been reported in the literature. We report on a 63-year-old European patient, presenting in our clinic for further treatm...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1385898
更新日期:2014-07-01 00:00:00
abstract:PURPOSE:In order to assess the efficacy and toxicity of oral estramustine phosphate (EMP) administration, low-dose EMP monotherapy (study 1) and very low-dose EMP therapy with luteinizing hormone-releasing hormone (LH-RH) agonist (study 2) were conducted in previously untreated prostate cancer and long-term outcomes we...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0029-1224657
更新日期:2010-01-01 00:00:00
abstract::c-Met plays a significant role in multiple cellular processes. Being encoded by a proto-oncogene, tyrosine kinase supports aggressive tumour behaviour such as tumour invasiveness and formation of metastases. For some subtypes of renal cell carcinoma studies have shown a association between c-Met expression and clinica...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-115401
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The laparoscopic technique is now applied to radical prostatectomy. However, even in laparoscopic prostatectomy, we need a small open wound to remove the prostate from the abdomen. We have developed a modified technique of extraperitoneal laparoscopic radical prostatectomy, exploiting this small open wound as a...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-41602
更新日期:2003-07-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the initiated consecutive diagnostic course after measurement of an elevated PSA value by the general practitioner. PATIENTS AND METHODS:406 patients who underwent ultrasound-guided transrectal biopsy of the prostate were assessed retrospectively. Using a standardised q...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0028-1098883
更新日期:2009-05-01 00:00:00
abstract::The most exciting data presented at the 2017 ASCO Annual Meeting included the results of the LATITUDE and STAMPEDE trials, which evaluated abiraterone plus prednisone combined with androgen-deprivation therapy (ADT) as a first-line treatment in men with newly diagnosed high-risk metastatic hormone-sensitive prostate c...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0852-3405
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:This systematic review evaluates international data on the medical effectiveness of orchiectomy and medical therapy with LH-RH analogues in patients with advanced prostate cancer. These results are discussed in the context of primary, neoadjuvant, adjuvant and intermittent hormone deprivation. MATERIALS AND ME...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1038282
更新日期:2008-11-01 00:00:00
abstract::Leiomyomas are benign neoplasms arising from smooth muscle cells. We describe the case of a 17-year-old boy admitted with progressive severe obstructive voiding symptoms. Retrograde urethrography showed a bulbous urethral stricture which was resected with primary urethral anastomosis. Histopathological examination con...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2007-993038
更新日期:2008-03-01 00:00:00
abstract:INTRODUCTION:Hydrocephalus as a complication of tuberculous orchiepididymitis is extremely rare. In this reported case, hydrocephalus was the consequence of a disseminated tuberculous process. CASE REPORT:A 28-year-old man was treated for a left-sided orchiepididymitis. He developed the signs of increased intracranial...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2004-830255
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:The aim of this study was to prove the efficacy of antegrade sclerotherapy for varicocele testis in patients with azoospermia and in patients with cryptozoospermia (less than 0.1 million spermatozoons/mL ejaculate). We have investigated the induction of spermatogenesis in patients with non-obstructive azoosperm...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2005-915619
更新日期:2006-03-01 00:00:00
abstract::The online marketing of physicians must be measured against the same advertising regulations as conventional marketing. In this context, the Medical Professional Code of Conduct, the Medical Products Advertising Act ("Heilmittelwerbegesetz") and the Law against Unfair Competition are particularly relevant. In addition...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-0893-6315
更新日期:2019-08-01 00:00:00
abstract::Stress urinary incontinence in women is a common problem in Germany, with approx. 5 million women suffering from incontinence symptoms. These numbers are increasing, due to demographic changes; the suspected numbers are even higher. Prior to treatment, an extended diagnostic approach - including urodynamics and cystos...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0043-121479
更新日期:2018-02-01 00:00:00
abstract::Between 15 and 20 % of patients diagnosed with renal cell carcinoma suffer from metastatic disease by the time of diagnosis. In addition to systemic therapy, there are various surgical strategies to treat the primary tumour, e. g. cytoreductive nephrectomy (CN) or palliative nephrectomy (PN). In the immunotherapy era,...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0658-0832
更新日期:2018-09-01 00:00:00
abstract::Pain is a cardinal symptom in 70 % of cancer patients. Even in developed countries, 30 to 80 % of these patients are inadequately treated. The main cause for this lack of care is not pain refractory to treatment but inadequate or incorrect use of analgesic drugs. A sufficient treatment of pain requires knowledge of th...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2004-830208
更新日期:2005-06-01 00:00:00
abstract::Urinary tract infections (UTI) are amongst the most frequent bacterial infections and therefore responsible for a great amount of antibiotic administration. UTI may present as benign, uncomplicated cystitis or severe, life-threatening urosepsis. Due to the heterogeneity of UTI the European Section of Infections in Uro...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1368176
更新日期:2014-03-01 00:00:00