[The German HTA report: orchiectomy versus LH-RH analogues in the treatment of advanced prostate carcinoma: are there any consequences for the daily health service?].

Abstract:

PURPOSE:This systematic review evaluates international data on the medical effectiveness of orchiectomy and medical therapy with LH-RH analogues in patients with advanced prostate cancer. These results are discussed in the context of primary, neoadjuvant, adjuvant and intermittent hormone deprivation. MATERIALS AND METHODS:A systematic, diversified literature analysis in the common medical and HTA databases and further media was conducted. RESULTS:All identified, randomised and controlled studies concerning the application of LH-RH analogues showed the same medical effectiveness for orchiectomy and for treatment with LH-RH analogues. Four different studies regarding the quality of life revealed no significant difference between the treatment with LH-RH analogues and the therapy with orchiectomy. CONCLUSION:According to available studies, there is clear evidence for the equivalent effectiveness of LH-RH analogues and orchiectomy in the treatment of advanced prostate cancer. A change back to orchiectomy - even though it is more cost-efficient - cannot be recommended when taking the extended indications for temporary hormone deprivation into consideration.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Rohde V,Grabein K,Weidner W,Wasem J,Hessel F

doi

10.1055/s-2008-1038282

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

448-55

issue

6

eissn

0001-7868

issn

1438-8820

journal_volume

39

pub_type

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