[The German HTA report: orchiectomy versus LH-RH analogues in the treatment of advanced prostate carcinoma: are there any consequences for the daily health service?].


PURPOSE:This systematic review evaluates international data on the medical effectiveness of orchiectomy and medical therapy with LH-RH analogues in patients with advanced prostate cancer. These results are discussed in the context of primary, neoadjuvant, adjuvant and intermittent hormone deprivation. MATERIALS AND METHODS:A systematic, diversified literature analysis in the common medical and HTA databases and further media was conducted. RESULTS:All identified, randomised and controlled studies concerning the application of LH-RH analogues showed the same medical effectiveness for orchiectomy and for treatment with LH-RH analogues. Four different studies regarding the quality of life revealed no significant difference between the treatment with LH-RH analogues and the therapy with orchiectomy. CONCLUSION:According to available studies, there is clear evidence for the equivalent effectiveness of LH-RH analogues and orchiectomy in the treatment of advanced prostate cancer. A change back to orchiectomy - even though it is more cost-efficient - cannot be recommended when taking the extended indications for temporary hormone deprivation into consideration.


Aktuelle Urol


Aktuelle Urologie


Rohde V,Grabein K,Weidner W,Wasem J,Hessel F




Has Abstract


2008-11-01 00:00:00












  • [Tuberculous orchiepididymitis and CNS complication].

    abstract:INTRODUCTION:Hydrocephalus as a complication of tuberculous orchiepididymitis is extremely rare. In this reported case, hydrocephalus was the consequence of a disseminated tuberculous process. CASE REPORT:A 28-year-old man was treated for a left-sided orchiepididymitis. He developed the signs of increased intracranial...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Miletic B,Morovic M,Tomic Z,Ticac B

    更新日期:2006-01-01 00:00:00

  • [Symptomatic renal tumours in metastatic renal cell carcinoma - surgical options].

    abstract::Between 15 and 20 % of patients diagnosed with renal cell carcinoma suffer from metastatic disease by the time of diagnosis. In addition to systemic therapy, there are various surgical strategies to treat the primary tumour, e. g. cytoreductive nephrectomy (CN) or palliative nephrectomy (PN). In the immunotherapy era,...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Gilbert N,Merseburger AS,Kramer M

    更新日期:2018-09-01 00:00:00

  • [Pediatric and adolescent varicocele - When, why and how to treat?]

    abstract::The treatment of a varicocele in childhood and adolescence is considered very controversial. In the past varicocele was often diagnosed during the medical examination for military purposes, but today varicocele is common in the J1 exam and is found rather frequently. However, we are still lacking evidence-based recomm...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Stein R,Zahn K,Younsi NF

    更新日期:2020-04-01 00:00:00

  • [Active surveillance for screen-detected prostate cancer - a strategy for the future?].

    abstract::For good reasons, newly detected prostate cancer must not necessarily be treated with curative -intent: Prostate-specific antigen screening leads to overdiagnosis in 54 %. Current international guidelines on the treatment of prostate cancer take this development into account by recommending "active surveillance" (AS) ...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Weissbach L,Schaefer C

    更新日期:2010-07-01 00:00:00

  • Quantitative analysis of testicular interstitial fibrosis after vasectomy in humans.

    abstract:PURPOSE:Germ cell differentiation, DNA synthesis, and apoptosis can be evaluated quantitatively. On the other hand, an interstitial lesion is difficult to examine. We have focused on the quantitative analysis of testicular interstitial fibrosis after vasectomy. MATERIALS AND METHODS:Forty testicular biopsy specimens f...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Shiraishi K,Takihara H,Naito K

    更新日期:2003-07-01 00:00:00

  • [Urinary tract infections].

    abstract::Urinary tract infections (UTI) are amongst the most frequent bacterial infections and therefore responsible for a great amount of antibiotic administration. UTI may present as benign, uncomplicated cystitis or severe, life-threatening urosepsis. Due to the heterogeneity of UTI the European Section of Infections in Uro...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Wagenlehner FM,Pilatz A,Naber K,Weidner W

    更新日期:2014-03-01 00:00:00

  • [Ultra-low-dose CT to search for stones in kidneys and collecting system].

    abstract::Unenhanced computed tomography (CT) has a sensitivity of 97.7 to 100 % for the detection of urolithiasis. Using a modified examination protocol, the radiation exposure of a CT examination can be reduced to the level of a single conventional radiographic view of the abdomen (ultra-low-dose CT), assuming the examination...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Rogalla P,Klüner C,Taupitz M

    更新日期:2004-08-01 00:00:00

  • [Potential for improvement by new resection and imaging techniques in TUR-B].

    abstract::Transurethral resection of bladder tumors (TURB) is the cornerstone in urological care of bladder cancer patients. Since the introduction of resectoscopes almost 100 years ago, little has changed in the basic resection technique. The further dissemination of the en-bloc resection (ERBT), which in contrast to fragmente...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Hennig MJP,Kramer MW

    更新日期:2020-08-01 00:00:00

  • [Terminology and Pathophysiology of Overactive Bladder (OAB)].

    abstract::In 2002, the International Continence Society defined the term overactive bladder (OAB) as a symptom syndrome that is accompanied by urgency with or without urge incontinence, frequency and nocturia. A proven urinary tract infection or other obvious pathologies must be excluded.The pathophysiology of OAB has not been ...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Höfner K

    更新日期:2016-12-01 00:00:00

  • [A retrospective analysis of functional and oncologic outcomes following surgical treatment of patients with pT1/pT2 renal cell carcinoma at a tertiary referral centre].

    abstract:INTRODUCTION:In patients with localised renal cell carcinoma, the only curative treatment option is surgical tumour excision. The aim of this study was to evaluate peri- and postoperative outcomes as well as oncologic and functional long-term results following surgical treatment of patients with renal cell carcinoma (p...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Ralla B,Buhl S,Goranova I,Maxeiner A,Friedersdorff F,Magheli A,Hinz S,Fuller TF,Miller K,Busch J

    更新日期:2020-06-01 00:00:00

  • [Monstrous scrotal leiomyoma: case report and literature survey].

    abstract::The scrotal leiomyoma is a rare benign tumour, deriving from the smooth muscle. This tumour entity constitutes a differential diagnosis to malignant testicular tumours. Up to now, only 8 cases have been reported in the literature. We report on a 63-year-old European patient, presenting in our clinic for further treatm...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Winkel A,Schmitz KJ,Kusche D

    更新日期:2014-07-01 00:00:00

  • [Current recommendations for the systemic treatment of metastatic renal cell carcinoma].

    abstract::Numerous substances are available for the treatment of metastatic renal cell carcinoma (mRCC). Therefore, medical treatment of patients with mRCC has become a very complex subject. This review summarises clinical studies and typical side-effects of currently available agents that have been approved in Germany. The aut...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Kröger N,Merseburger AS,Bedke J

    更新日期:2019-12-01 00:00:00

  • [Significance and Value of PSMA Ligands in Prostate Cancer].

    abstract::In recent years, PSMA-targeting PET tracers such as 68Ga-PSMA-11 have shown promising results, thus contributing to a better management of prostate cancer patients. At the present time, 68Ga-PSMA-11 is most frequently used for diagnostic evaluation in the setting of biochemical recurrence of prostate cancer. In this c...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Gasch C,Körber S,Kremer C,Eiber M,Kratochwil C,Haberkorn U,Hohenfellner M,Hadaschik B,Giesel FL

    更新日期:2017-04-01 00:00:00

  • [Bladder wall tension with physiological bladder emptying in patients with detrusor hyperactivity and infravesical obstruction].

    abstract:PURPOSE:The range of maximum bladder smooth muscle tension in the published literature varies between 1.3 and 59 N/cm (2) depending on the experimental setup. Based on own animal trials, we attempted to determine bladder wall tension during detrusor contraction in physiological and obstructed voiding and during detruso...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Bross S,Braun PM,Michel MS,Knoll T,Martinez Portillo FJ,Jünemann KP,Alken P

    更新日期:2003-01-01 00:00:00

  • [Physician health: What makes us ill? What keeps us healthy?]

    abstract::The medical profession is a particular health risk. Internal reasons for this are the common practice of self-diagnosis and self-therapy, presenteeism (work despite illness), and increased risks of addiction and suicide. External reasons include infectious diseases, violence against health professionals, the increasin...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Braun J,Jocham D

    更新日期:2019-04-01 00:00:00

  • [Abiraterone plus prednisone in patients with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC)].

    abstract::The most exciting data presented at the 2017 ASCO Annual Meeting included the results of the LATITUDE and STAMPEDE trials, which evaluated abiraterone plus prednisone combined with androgen-deprivation therapy (ADT) as a first-line treatment in men with newly diagnosed high-risk metastatic hormone-sensitive prostate c...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Miller K

    更新日期:2019-12-01 00:00:00

  • Imperative and elective indications for nephron-sparing surgery for renal tumors: long-term oncological follow-up.

    abstract:INTRODUCTION:Nephron-sparing surgery (NSS) is mandatory for patients with renal tumors in both kidneys or in a solitary kidney in order to preserve renal function (imperative indication). NSS has also become the gold standard (elective indication) for small unilateral renal tumors (< 4 cm) with a normal contralateral k...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Roos FC,Pahernik S,Brenner W,Thüroff JW

    更新日期:2010-01-01 00:00:00

  • [Asymptomatic kidney stones: active surveillance vs. treatment].

    abstract::The prevalence of kidney stones is increasing worldwide. Asymptomatic non-obstructing kidney stones are increasingly detected as an incidental finding on radiologic imaging, which has been performed more frequently over the last decades. Beside the current interventional treatment modalities such as extracorporeal sho...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Neisius A,Thomas C,Roos FC,Hampel C,Fritsche HM,Bach T,Thüroff JW,Knoll T

    更新日期:2015-09-01 00:00:00

  • [Bladder hernia: report of a case series and review of the literature].

    abstract::Inguinal bladder hernia accounts for only 1 - 4 % of all inguinal hernias. It may be difficult to diagnose due to the atypical symptoms. In most cases, the diagnosis is only made intraoperatively. However, a preoperative diagnosis is important to avoid possible iatrogenic complications. We report a case series of five...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Trenti E,Palermo S,Huqi D,Ladurner C,Krause P,Pycha A,Comploj E

    更新日期:2020-06-18 00:00:00

  • [Synchronous bilateral renal cell cancer with a single ovarian metastasis and a fibromuscular dysplasia of the renal artery].

    abstract:INTRODUCTION:Ovarian metastases of renal cell cancer (RCC) are extremely rare with less than 20 cases reported to date. These metastases occur in the majority of cases metachronous (i. e. prior to or after identification of the primary tumour) or--such as in our case--synchronous. CASE REPORT:A 42-year-old women was d...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Madersbacher S,Ponholzer A,Franz K,Höltl W

    更新日期:2007-01-01 00:00:00

  • [Intravesical salpingiosis: case report and review of the literature].

    abstract::Endosalpingiosis of the urinary bladder is a rare benign condition characterised by the presence of ectopic endosalpingeal tissue in the bladder. If histology shows two or more Müllerian-derived components, this condition is referred to as Müllerianosis.To our knowledge less than 20 cases of Müllerianosis and 5 cases ...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Gilbert N,Guo X,Bauer J,Hennig M,Kümpers C,Merseburger AS

    更新日期:2018-06-01 00:00:00

  • [Partial Nephrectomy in cT1 Renal Tumours: Conventional Laparoscopic Partial Nephrectomy Compared with LESS Partial Nephrectomy in SITUS Technique].

    abstract:BACKGROUND:Partial nephrectomy is the treatment of choice for clinical stage 1 renal tumours. Open partial nephrectomy is the standard operative technique. The use of minimally-invasive strategies such as laparoscopic, robot-assisted partial nephrectomy or laparoendoscopic single site (LESS) partial nephrectomy has inc...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Wolters M,Wohlatz L,Neumann T,Jutzi S,Peters I,von Klot C,Imkamp F,Lutze B,Kuczyk MA,Nagele U,Herrmann TR

    更新日期:2015-11-01 00:00:00

  • [Percutaneous Stone Treatment Today: Standard-, Mini-, Micro-, Ultramini-PCNL].

    abstract:BACKGROUND:Percutaneous nephrolithotripsy (PCNL) is one of the main interventional treatment modalities for large kidney stones (> 2 cm diameter). With the implementation of miniaturised techniques the indications for PCNL have been broadened to smaller stones. Especially for urologists without emphasis on endourology ...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Wilhelm K,Fritsche HM,Netsch C,AG „Endourologie und Urolithiasis“ der GeSRU Academics.

    更新日期:2015-07-01 00:00:00

  • [The impact of ALA (5-aminolevulinic acid)-fluorescence detection on the prognosis of superficial bladder cancer].

    abstract:PURPOSE:Throughout the past years, several studies have shown that fluorescence cystoscopy with ALA (5-aminolevulinic acid) improves the detection rate of superficial bladder tumors by approximately 20 % compared to standard white light cystoscopy. These results suggest a reduced rate of residual/recurrent tumors with ...

    journal_title:Aktuelle Urologie

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Daniltchenko D,Riedl C,Koenig F,Daha LK,Sachs M,Schnorr D

    更新日期:2004-11-01 00:00:00

  • [Prevention of Catheter-Associated Urinary Tract Infections].

    abstract::With a share of 22.4%, nosocomial urinary tract infections (nUTIs) are among the most frequent infections acquired in hospitals, along with surgical site infections (24.7%), pneumonia (21.5%), clostridium difficile infections (6.6%) and primary sepsis (6%) 1. 80% of all nUTIs are associated with indwelling urinary cat...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Piechota H

    更新日期:2016-05-01 00:00:00

  • [Cancer control in focus insights and future perspectives for the focal treatment of prostate cancer].

    abstract::Faced with the dilemma of choosing between the extremes of standard whole gland therapy and active surveillance, those affected by prostate cancer have recently been on the lookout for less invasive alternatives. Particularly the question of whether it would be possible in low risk cancer to treat only the tumour itse...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Schostak M,Köllermann J,Hadaschik B,Blana A,Ganzer R,Henkel T,Köhrmann KU,Liehr UB,Machtens S,Roosen A,Salomon G,Sentker L,Witzsch U,Schlemmer HP,Baumunk D

    更新日期:2015-01-01 00:00:00

  • [Extended salvage pelvic and retroperitoneal lymph node dissection due to prostate cancer relapse].

    abstract::Treatment of a biochemical prostate cancer relapse represents a difficult clinical dilemma, which has remained without a definitive solution so far. Based on clinical studies, we combine radical prostatectomy with extended pelvic lymph node dissection in intermediate and high risk patients as a routine procedure at ou...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Osmonov DK,Aksenov AV,Jünemann KP

    更新日期:2013-01-01 00:00:00

  • [Current Aspects of Epididymo-Orchitis].

    abstract:BACKGROUND:Acute epididymitis is an inflammation of the epididymis. It mostly occurs unilaterally and may spread to the testis ('epididymo-orchitis') if untreated. Increasing technological advances allow for an even more detailed examination of concurrent symptoms such as ejaculate changes and the whole spectrum of pat...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Pilatz A,Boecker M,Schuppe HC,Wagenlehner F

    更新日期:2016-05-01 00:00:00

  • Final report on low-dose estramustine phosphate (EMP) monotherapy and very low-dose EMP therapy combined with LH-RH agonist for previously untreated advanced prostate cancer.

    abstract:PURPOSE:In order to assess the efficacy and toxicity of oral estramustine phosphate (EMP) administration, low-dose EMP monotherapy (study 1) and very low-dose EMP therapy with luteinizing hormone-releasing hormone (LH-RH) agonist (study 2) were conducted in previously untreated prostate cancer and long-term outcomes we...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章


    authors: Kitamura T,Suzuki M,Nishimatsu H,Kurosaki T,Enomoto Y,Fukuhara H,Kume H,Takeuchi T,Miao L,Jiangang H,Xiaoqiang L

    更新日期:2010-01-01 00:00:00

  • [Tomatoes and lycopene in prevention and therapy--is there an evidence for prostate diseases?].

    abstract::Tomatoes are discussed to have an important role in the prevention of and therapy for prostate cancer (PCA). Whether or not they are also useful in the primary and secondary prevention of benign prostate hyperplasia (BPH) is not clear. This review summarises the results of original contributions with a focus on interv...

    journal_title:Aktuelle Urologie

    pub_type: 杂志文章,评审


    authors: Ellinger S,Ellinger J,Müller SC,Stehle P

    更新日期:2009-01-01 00:00:00