[Tomatoes and lycopene in prevention and therapy--is there an evidence for prostate diseases?].

Abstract:

:Tomatoes are discussed to have an important role in the prevention of and therapy for prostate cancer (PCA). Whether or not they are also useful in the primary and secondary prevention of benign prostate hyperplasia (BPH) is not clear. This review summarises the results of original contributions with a focus on interventional studies. Whereas epidemiological studies on BPH prevention provide no evidence for a preventive potential of tomatoes and tomato products, the majority of interventional trials points to an increased DNA resistance against oxidative-induced damage. Even though their effect on a surrogate marker of the IGF pathway cannot be evaluated so far due to insufficient data, the consumption of tomatoes and tomato products may probably protect from PCA--at least when considering low-grade PCA. Thus, regular consumption of these foods can be recommended for the prevention of PCA. Tomato products might also be useful in the therapy for BPH and PCA. The intake of isolated lycopene does not protect from the development of PCA. However, in the doses achieved by consumption of tomato products, lycopene ingestion might also be effective in PCA therapy.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Ellinger S,Ellinger J,Müller SC,Stehle P

doi

10.1055/s-2008-1077031

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

37-43

issue

1

eissn

0001-7868

issn

1438-8820

journal_volume

40

pub_type

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