[Abiraterone plus prednisone in patients with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC)].

Abstract:

:The most exciting data presented at the 2017 ASCO Annual Meeting included the results of the LATITUDE and STAMPEDE trials, which evaluated abiraterone plus prednisone combined with androgen-deprivation therapy (ADT) as a first-line treatment in men with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC), demonstrating a practice-changing alternative to chemo-hormonal treatment with docetaxel plus ADT. In both trials, the addition of abiraterone plus prednisone to ADT significantly prolonged both progression-free survival and overall survival. In the absence of head-to-head evidence, it remains unclear if abiraterone plus prednisone and ADT should be the new gold standard for patients with newly diagnosed high-risk mHSPC. However, the results of indirect comparisons demonstrate that abiraterone plus prednisone is similarly or even more effective compared with chemotherapy and better tolerated overall. :Die Ergebnisse der beiden Studien LATITUDE 1 und STAMPEDE 2 zur Kombinationstherapie von Abirateron plus Prednison (Abirateron/P) mit konventioneller ADT haben eine praxisverändernde Alternative zur kombinierten Hormon-Chemotherapie mit ADT plus Docetaxel in der Erstlinientherapie des neu diagnostizierten Hochrisiko-metastasierten hormonsensitiven Prostatakarzinoms (mHSPC) aufgezeigt. In beiden Studien führte Abirateron/P zu einer deutlichen Verlängerung des progressionsfreien und Gesamtüberlebens. Ob Abirateron/P plus ADT als neuer Goldstandard beim neu diagnostizierten Hochrisiko-mHSPC anzusehen ist, kann derzeit nicht sicher beurteilt werden, da direkte Vergleichsstudien noch fehlen. Die vorliegenden indirekten Daten zeigen aber, dass Abirateron/P eine mindestens vergleichbare, wenn nicht sogar etwas höhere Effektivität aufweist, bei einer insgesamt besseren Verträglichkeit.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Miller K

doi

10.1055/a-0852-3405

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

625-628

issue

6

eissn

0001-7868

issn

1438-8820

journal_volume

50

pub_type

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