Abstract:
:The most exciting data presented at the 2017 ASCO Annual Meeting included the results of the LATITUDE and STAMPEDE trials, which evaluated abiraterone plus prednisone combined with androgen-deprivation therapy (ADT) as a first-line treatment in men with newly diagnosed high-risk metastatic hormone-sensitive prostate cancer (mHSPC), demonstrating a practice-changing alternative to chemo-hormonal treatment with docetaxel plus ADT. In both trials, the addition of abiraterone plus prednisone to ADT significantly prolonged both progression-free survival and overall survival. In the absence of head-to-head evidence, it remains unclear if abiraterone plus prednisone and ADT should be the new gold standard for patients with newly diagnosed high-risk mHSPC. However, the results of indirect comparisons demonstrate that abiraterone plus prednisone is similarly or even more effective compared with chemotherapy and better tolerated overall. :Die Ergebnisse der beiden Studien LATITUDE 1 und STAMPEDE 2 zur Kombinationstherapie von Abirateron plus Prednison (Abirateron/P) mit konventioneller ADT haben eine praxisverändernde Alternative zur kombinierten Hormon-Chemotherapie mit ADT plus Docetaxel in der Erstlinientherapie des neu diagnostizierten Hochrisiko-metastasierten hormonsensitiven Prostatakarzinoms (mHSPC) aufgezeigt. In beiden Studien führte Abirateron/P zu einer deutlichen Verlängerung des progressionsfreien und Gesamtüberlebens. Ob Abirateron/P plus ADT als neuer Goldstandard beim neu diagnostizierten Hochrisiko-mHSPC anzusehen ist, kann derzeit nicht sicher beurteilt werden, da direkte Vergleichsstudien noch fehlen. Die vorliegenden indirekten Daten zeigen aber, dass Abirateron/P eine mindestens vergleichbare, wenn nicht sogar etwas höhere Effektivität aufweist, bei einer insgesamt besseren Verträglichkeit.
journal_name
Aktuelle Uroljournal_title
Aktuelle Urologieauthors
Miller Kdoi
10.1055/a-0852-3405subject
Has Abstractpub_date
2019-12-01 00:00:00pages
625-628issue
6eissn
0001-7868issn
1438-8820journal_volume
50pub_type
杂志文章,评审abstract::The urethral syndrome with urethral pain and bladder voiding disorders is a diagnosis of exclusion. Possible aetiologies are diverse and include organic, functional and inflammatory pathologies of the urethra. Infections, inflammation of the paraurethral glands, spasms of the sphincter muscle and/or of the pelvic floo...
journal_title:Aktuelle Urologie
pub_type: 评论,杂志文章
doi:10.1055/s-0042-106662
更新日期:2016-08-01 00:00:00
abstract::Pharmacological treatment of BPS is often considered the first therapeutic approach for patients who experience progression in lower urinary tract symptoms (LUTS).α1-adrenoceptor antagonists are often chosen as the first line pharmacological treatment, due to their rapid onset of action, as well as their significant i...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0649-0702
更新日期:2018-08-01 00:00:00
abstract:AIM:The aim of the present study was to evaluate the initiated consecutive diagnostic course after measurement of an elevated PSA value by the general practitioner. PATIENTS AND METHODS:406 patients who underwent ultrasound-guided transrectal biopsy of the prostate were assessed retrospectively. Using a standardised q...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0028-1098883
更新日期:2009-05-01 00:00:00
abstract::At present medical castration employing luteinising hormone releasing hormone (LHRH) agonists is the standard of care for patients with advanced prostate cancer. LHRH agonists suppress the synthesis of testosterone to a castration level. In contrast to surgical castration, medical castration is reversible. However LHR...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0028-1098882
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:This systematic review evaluates international data on the medical effectiveness of orchiectomy and medical therapy with LH-RH analogues in patients with advanced prostate cancer. These results are discussed in the context of primary, neoadjuvant, adjuvant and intermittent hormone deprivation. MATERIALS AND ME...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1038282
更新日期:2008-11-01 00:00:00
abstract::Osteosarcoma of the prostate is a rare finding. These tumours usually occur years after radiotherapy for prostate cancer. We report the case of a 74-year-old man with prostate cancer who had been treated with radiotherapy and androgen deprivation therapy. The man presented with urinary retention and his prostate was t...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0032-1323744
更新日期:2012-12-01 00:00:00
abstract::Although ureteroarterial fistulas are rare, they result in a high mortality because of the massive urogenital haemorrhage. The diagnosis is often difficult even when invasive measures are applied. Including the ureteroarterial fistula in the diagnostic process in cases of macrohaematuria with a positive medical histor...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0034-1376953
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Throughout the past years, several studies have shown that fluorescence cystoscopy with ALA (5-aminolevulinic acid) improves the detection rate of superficial bladder tumors by approximately 20 % compared to standard white light cystoscopy. These results suggest a reduced rate of residual/recurrent tumors with ...
journal_title:Aktuelle Urologie
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1055/s-2004-818544
更新日期:2004-11-01 00:00:00
abstract:PURPOSE:The optimal treatment options for lower pole stones with a diameter below 15 mm are controversially discussed. Extracorporeal shock wave lithotripsy (ESWL) is non-invasive but is hampered by low stone-free rates and a significant retreatment rate. Flexible ureterorenoscopy (URS) has been demonstrated to have hi...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0029-1224680
更新日期:2009-11-01 00:00:00
abstract::Endosalpingiosis of the urinary bladder is a rare benign condition characterised by the presence of ectopic endosalpingeal tissue in the bladder. If histology shows two or more Müllerian-derived components, this condition is referred to as Müllerianosis.To our knowledge less than 20 cases of Müllerianosis and 5 cases ...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0043-110039
更新日期:2018-06-01 00:00:00
abstract::Patients with metastatic renal cell carcinoma have a life-limiting prognosis. Therefore, the aim of therapy is normally palliative care. Nevertheless, substantial achievements have been made in the past years. Cytokines as long-term standard therapy have been more and more replaced by new targeted therapies. Sunitinib...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1363228
更新日期:2014-01-01 00:00:00
abstract::The online marketing of physicians must be measured against the same advertising regulations as conventional marketing. In this context, the Medical Professional Code of Conduct, the Medical Products Advertising Act ("Heilmittelwerbegesetz") and the Law against Unfair Competition are particularly relevant. In addition...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-0893-6315
更新日期:2019-08-01 00:00:00
abstract::The prevalence of kidney stones is increasing worldwide. Asymptomatic non-obstructing kidney stones are increasingly detected as an incidental finding on radiologic imaging, which has been performed more frequently over the last decades. Beside the current interventional treatment modalities such as extracorporeal sho...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1559651
更新日期:2015-09-01 00:00:00
abstract::Pain is a cardinal symptom in 70 % of cancer patients. Even in developed countries, 30 to 80 % of these patients are inadequately treated. The main cause for this lack of care is not pain refractory to treatment but inadequate or incorrect use of analgesic drugs. A sufficient treatment of pain requires knowledge of th...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2004-830208
更新日期:2005-06-01 00:00:00
abstract:INTRODUCTION:Peritoneal carcinomatosis is a rare finding in metastatic prostate cancer. In the literature peritoneal carcinomatosis is usually reported in its final stages with multiple metastases. A single peritoneal carcinomatosis with no further metastases is a very rare finding. CASE REPORT:We report the case of a...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2007-959185
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Percutaneous nephrolithotripsy (PCNL) is one of the main interventional treatment modalities for large kidney stones (> 2 cm diameter). With the implementation of miniaturised techniques the indications for PCNL have been broadened to smaller stones. Especially for urologists without emphasis on endourology ...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1555863
更新日期:2015-07-01 00:00:00
abstract::Faced with the dilemma of choosing between the extremes of standard whole gland therapy and active surveillance, those affected by prostate cancer have recently been on the lookout for less invasive alternatives. Particularly the question of whether it would be possible in low risk cancer to treat only the tumour itse...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1396803
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have p...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-0759-0029
更新日期:2018-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to prove the efficacy of antegrade sclerotherapy for varicocele testis in patients with azoospermia and in patients with cryptozoospermia (less than 0.1 million spermatozoons/mL ejaculate). We have investigated the induction of spermatogenesis in patients with non-obstructive azoosperm...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2005-915619
更新日期:2006-03-01 00:00:00
abstract::Urinary tract infections (UTI) are amongst the most frequent bacterial infections and therefore responsible for a great amount of antibiotic administration. UTI may present as benign, uncomplicated cystitis or severe, life-threatening urosepsis. Due to the heterogeneity of UTI the European Section of Infections in Uro...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1368176
更新日期:2014-03-01 00:00:00
abstract::We report on a male newborn with urinary ascites and perirenal urinoma due to calyceal rupture caused by bladder outlet obstruction and posterior urethral valves. Despite the presence of left-sided high-grade reflux, the "pop-off" mechanism occurred in the non-refluxing right kidney. Impressive normalization of the up...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-43175
更新日期:2003-10-01 00:00:00
abstract::Testicular and paratesticular cystadenomas arise from an oviduct-like structure, which, morphologically, is almost identical with the ovarian surface epithelium. These are very rare benign tumours of adults. They present as asymptomatic cystic lesions. Bilateral paratesticular cystadenomas are associated with the Von-...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0043-101214
更新日期:2018-06-01 00:00:00
abstract::Leiomyomas are benign neoplasms arising from smooth muscle cells. We describe the case of a 17-year-old boy admitted with progressive severe obstructive voiding symptoms. Retrograde urethrography showed a bulbous urethral stricture which was resected with primary urethral anastomosis. Histopathological examination con...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2007-993038
更新日期:2008-03-01 00:00:00
abstract::Abiraterone acetate (in combination with prednisone/prednisolone (abiraterone/P)), enzalutamide or docetaxel may all be used for the first-line treatment of asymptomatic or mildly symptomatic mCRPC. As treatment with docetaxel can result in the emergence of considerable adverse events, the less toxic substances abirat...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-1036-1568
更新日期:2020-12-01 00:00:00
abstract::The outpatient forensic aftercare department of the Charité Berlin treated 32 paraphilic sex offenders with GnRH analogues within the past 5 years. Out of those patients, three men suffered from urolithiasis and were in need of treatment. All 3 patients had previously developed osteopenia/osteoporosis while on antiand...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0042-112999
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Acute epididymitis is an inflammation of the epididymis. It mostly occurs unilaterally and may spread to the testis ('epididymo-orchitis') if untreated. Increasing technological advances allow for an even more detailed examination of concurrent symptoms such as ejaculate changes and the whole spectrum of pat...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-104803
更新日期:2016-05-01 00:00:00
abstract::c-Met plays a significant role in multiple cellular processes. Being encoded by a proto-oncogene, tyrosine kinase supports aggressive tumour behaviour such as tumour invasiveness and formation of metastases. For some subtypes of renal cell carcinoma studies have shown a association between c-Met expression and clinica...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-115401
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:The range of maximum bladder smooth muscle tension in the published literature varies between 1.3 and 59 N/cm (2) depending on the experimental setup. Based on own animal trials, we attempted to determine bladder wall tension during detrusor contraction in physiological and obstructed voiding and during detruso...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-37558
更新日期:2003-01-01 00:00:00
abstract::Transurethral resection of bladder tumors (TURB) is the cornerstone in urological care of bladder cancer patients. Since the introduction of resectoscopes almost 100 years ago, little has changed in the basic resection technique. The further dissemination of the en-bloc resection (ERBT), which in contrast to fragmente...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-1171-1137
更新日期:2020-08-01 00:00:00
abstract::Tomatoes are discussed to have an important role in the prevention of and therapy for prostate cancer (PCA). Whether or not they are also useful in the primary and secondary prevention of benign prostate hyperplasia (BPH) is not clear. This review summarises the results of original contributions with a focus on interv...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1077031
更新日期:2009-01-01 00:00:00