[Sequential therapy for asymptomatic or mildly symptomatic metastatic castration-resistant prostate cancer].

Abstract:

:Abiraterone acetate (in combination with prednisone/prednisolone (abiraterone/P)), enzalutamide or docetaxel may all be used for the first-line treatment of asymptomatic or mildly symptomatic mCRPC. As treatment with docetaxel can result in the emergence of considerable adverse events, the less toxic substances abiraterone/P and enzalutamide are important alternatives. Apart from the safety and clinical effectiveness of these therapies, their optimal sequencing can play a significant role when choosing a mCRPC first-line therapy. Until recently, only retrospective trials were conducted, investigating the sequential use of abiraterone/P and enzalutamide in asymptomatic or mildly symptomatic mCRPC. However, the British Columbia Cancer Agency (BCCA) has now published results from a phase II randomised cross-over trial, which directly compared the safety and efficacy of abiraterone/P and enzalutamide in the first and second line. :Beim nicht oder mild symptomatischen metastasierten kastrationsresistenten Prostatakarzinom (mCRPC) können sowohl die modernen antihormonellen Wirkstoffe Abirateronacetat plus Prednison/Prednisolon (Abirateron/P) und Enzalutamid als auch eine Chemotherapie mit Docetaxel zum Einsatz kommen. Da die Behandlung mit Docetaxel teils ausgeprägte Nebenwirkungen haben kann, ist eine wichtige Therapiealternative die insgesamt besser verträgliche antihormonelle Therapie. Neben der Wirksamkeit und Verträglichkeit kann bei der Wahl der mCRPC-Erstlinientherapie zudem der Einfluss auf die Wirksamkeit von Folgetherapien eine wichtige Rolle spielen. Bisher lagen nur retrospektive Studien zum sequenziellen Einsatz von Abirateron/P und Enzalutamid bei dieser Indikation vor. In einer prospektiven, randomisierten Phase-II-Studie der British Columbia Cancer Agency (BCCA) wurden Abirateron/P und Enzalutamid nun erstmals bez. ihrer Wirksamkeit und Verträglichkeit in der Erstlinientherapie des nicht oder mild symptomatischen mCRPC sowie der Folgetherapie miteinander verglichen.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Miller K

doi

10.1055/a-1036-1568

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

557-561

issue

6

eissn

0001-7868

issn

1438-8820

journal_volume

51

pub_type

杂志文章
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    更新日期:2017-04-01 00:00:00

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    更新日期:2018-08-01 00:00:00

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    更新日期:2016-08-01 00:00:00

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    更新日期:2014-03-01 00:00:00

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    更新日期:2019-08-01 00:00:00

  • Final report on low-dose estramustine phosphate (EMP) monotherapy and very low-dose EMP therapy combined with LH-RH agonist for previously untreated advanced prostate cancer.

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    更新日期:2010-01-01 00:00:00

  • [The pediatric pelvic kidney--a retrospective analysis].

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    pub_type: 杂志文章

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    authors: Engelhardt PF,Lusuardi L,Riedl CR,Riccabona M

    更新日期:2006-07-01 00:00:00

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    更新日期:2015-07-01 00:00:00

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    更新日期:2018-02-01 00:00:00

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  • [Tuberculous orchiepididymitis and CNS complication].

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    更新日期:2006-01-01 00:00:00

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    更新日期:2016-12-01 00:00:00

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  • [Augmented reality and virtual reality in the operating theatre status quo und quo vadis].

    abstract:INTRODUCTION: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have p...

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    更新日期:2018-12-01 00:00:00

  • [Enhanced endoscopic imaging for urothelial cancer].

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  • [Ureteroarterial fistula - pathogenesis, diagnostics, and therapeutic outcome].

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    更新日期:2014-05-01 00:00:00

  • [Interdisciplinary recommendations for the treatment of metastatic renal cell carcinoma].

    abstract::Patients with metastatic renal cell carcinoma have a life-limiting prognosis. Therefore, the aim of therapy is normally palliative care. Nevertheless, substantial achievements have been made in the past years. Cytokines as long-term standard therapy have been more and more replaced by new targeted therapies. Sunitinib...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1363228

    authors: Miller K,Bergmann L,Gschwend J,Keilholz U,Kuczyk M

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  • [Induction of spermatogenesis in patients with non-obstructive azoospermia after antegrade sclerotherapy].

    abstract:PURPOSE:The aim of this study was to prove the efficacy of antegrade sclerotherapy for varicocele testis in patients with azoospermia and in patients with cryptozoospermia (less than 0.1 million spermatozoons/mL ejaculate). We have investigated the induction of spermatogenesis in patients with non-obstructive azoosperm...

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    更新日期:2006-03-01 00:00:00

  • [Prevention of Catheter-Associated Urinary Tract Infections].

    abstract::With a share of 22.4%, nosocomial urinary tract infections (nUTIs) are among the most frequent infections acquired in hospitals, along with surgical site infections (24.7%), pneumonia (21.5%), clostridium difficile infections (6.6%) and primary sepsis (6%) 1. 80% of all nUTIs are associated with indwelling urinary cat...

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    pub_type: 杂志文章,评审

    doi:10.1055/s-0042-101845

    authors: Piechota H

    更新日期:2016-05-01 00:00:00