[c-MET Oncogene in Renal Cell Carcinomas].

Abstract:

:c-Met plays a significant role in multiple cellular processes. Being encoded by a proto-oncogene, tyrosine kinase supports aggressive tumour behaviour such as tumour invasiveness and formation of metastases. For some subtypes of renal cell carcinoma studies have shown a association between c-Met expression and clinical outcome or prognosis. Therefore, c-Met represents a prognostic marker in renal cell carcinoma.Furthermore, c-MET will play a decisive role as a possible target for targeted therapies in the era of personalised medicine. Especially for RCC, the dual inhibition of VEGF and c-MET tyrosine kinase in cases of metastatic, treatment-resistant tumours is gaining clinical relevance. The role of c-Met has not been fully elucidated for all subtypes of renal cell carcinomas. The relevance of c-Met for the remaining subtypes of renal tumours has yet to be clarified.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Erlmeier F,Weichert W,Autenrieth M,Ivanyi P,Hartmann A,Steffens S

doi

10.1055/s-0042-115401

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

475-479

issue

6

eissn

0001-7868

issn

1438-8820

journal_volume

47

pub_type

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