Quantitative analysis of testicular interstitial fibrosis after vasectomy in humans.

Abstract:

PURPOSE:Germ cell differentiation, DNA synthesis, and apoptosis can be evaluated quantitatively. On the other hand, an interstitial lesion is difficult to examine. We have focused on the quantitative analysis of testicular interstitial fibrosis after vasectomy. MATERIALS AND METHODS:Forty testicular biopsy specimens from twenty consecutive men were obtained at vasovasostomy. Johnsen's mean score was calculated from testicular biopsy specimens. Percent of interstitial fibrosis was determined quantitatively by the NIH-Image after Masson-trichrome staining. RESULTS:A significant increase in interstitial fibrosis was observed along with the obstructive interval (p < 0.001). Johnsen's mean score count did not associate with the obstructive interval. CONCLUSION:Interstitial lesions of testicular physiology and pathophysiology can be evaluated using the NIH-Image. Interstitial fibrosis, but not the intraseminiferous status, reflects the irreversible damage of vasectomized testes.

journal_name

Aktuelle Urol

journal_title

Aktuelle Urologie

authors

Shiraishi K,Takihara H,Naito K

doi

10.1055/s-2003-41612

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

262-4

issue

4

eissn

0001-7868

issn

1438-8820

journal_volume

34

pub_type

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