Abstract:
:Transurethral resection of bladder tumors (TURB) is the cornerstone in urological care of bladder cancer patients. Since the introduction of resectoscopes almost 100 years ago, little has changed in the basic resection technique. The further dissemination of the en-bloc resection (ERBT), which in contrast to fragmented removal preserves the tumor's integrity, might re-adjust the surgical landscape. Benefits attributed to ERBT are better histopathological judgment and higher detrusor muscle rate. In addition, trends for a lower rate of so-called "in-field" recurrences as well as a reduced complication rate have been described. However, randomised, controlled studies with appropriate case numbers and methodology are pending. Few innovations in improved endoscopic tumor diagnostics have been added in recent years. Worth mentioning is the multiparametric magnetic resonance imaging of the bladder, which is intended to improve the accuracy of local tumor propagation compared to conventional imaging alone, as well as techniques in the field of artificial intelligence. The intention of this article is to provide an up-to-date status on EBRT as well as the local diagnostics for urinary bladder tumors. :Die transurethrale Resektion von Harnblasentumoren (TURB) ist ein Grundpfeiler in der urologischen Versorgung von Harnblasenkarzinompatienten. Seit der initialen Einführung von Resektoskopen vor knapp 100 Jahren hat sich an der grundlegenden Resektionstechnik wenig geändert. Erst mit der Verbreitung der sog. En-Bloc-Resektion (ERBT), welche im Gegensatz zur fragmentierten Abtragung die Tumorintegrität erhält, findet eine zögerliche Neujustierung der Technik statt. Vorteile, die der ERBT zugeschrieben werden, sind die bessere histopathologische Beurteilbarkeit und die höhere Detrusormuskulaturrate. Zudem sind Tendenzen für eine geringere Rate an sog. „in-field“ Rezidiven sowie eine verminderte Komplikationsrate beschrieben worden. Randomisierte, kontrollierte Studien mit geeigneter Fallzahl und Methodik stehen allerdings aus. Nur wenige Neuerungen hinsichtlich verbesserter endoskopischer Tumordiagnostik sind in den letzten Jahren hinzugekommen. Erwähnenswert ist die multiparametrische Magnetresonanztomografie der Blase, welche die Genauigkeit der lokalen Tumorausbreitung im Vergleich zur alleinigen konventionellen Bildgebung verbessern soll, sowie Verfahren aus dem Bereich der künstlichen Intelligenz. Die Intention dieses Artikels ist es einen aktuellen Stand über die ERBT sowie die lokale Diagnostik bei Harnblasentumoren zu geben.
journal_name
Aktuelle Uroljournal_title
Aktuelle Urologieauthors
Hennig MJP,Kramer MWdoi
10.1055/a-1171-1137subject
Has Abstractpub_date
2020-08-01 00:00:00pages
348-352issue
4eissn
0001-7868issn
1438-8820journal_volume
51pub_type
杂志文章abstract:PURPOSE:In order to assess the efficacy and toxicity of oral estramustine phosphate (EMP) administration, low-dose EMP monotherapy (study 1) and very low-dose EMP therapy with luteinizing hormone-releasing hormone (LH-RH) agonist (study 2) were conducted in previously untreated prostate cancer and long-term outcomes we...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0029-1224657
更新日期:2010-01-01 00:00:00
abstract::This article reports on the effective and quick treatment of angioceratoma scroti sive vulvae Fordyce using a 940-nm diode laser. Up to now the usage of this laser has not been described for this indication and we show that it provides a successful therapeutic alternative with few side effects. ...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0031-1283790
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION: Virtual reality (VR) is an artificially simulated environment permitting interaction. On the other hand, augmented reality (AR) is an enhanced version of reality created by the use of technology to overlay digital information on an image of something being viewed through a device. Both technologies have p...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-0759-0029
更新日期:2018-12-01 00:00:00
abstract:MATERIAL AND METHODS:100 consecutive cases after radical prostatectomy with a bacterial count of 10(4) CFU/ml in midstream urine were followed during urological inpatient rehabilitation without antibiotic treatment. Before discharge, a follow-up examination with a urine dipstick and a second urine culture were performe...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0042-103198
更新日期:2016-05-01 00:00:00
abstract::Testicular and paratesticular cystadenomas arise from an oviduct-like structure, which, morphologically, is almost identical with the ovarian surface epithelium. These are very rare benign tumours of adults. They present as asymptomatic cystic lesions. Bilateral paratesticular cystadenomas are associated with the Von-...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0043-101214
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to prove the efficacy of antegrade sclerotherapy for varicocele testis in patients with azoospermia and in patients with cryptozoospermia (less than 0.1 million spermatozoons/mL ejaculate). We have investigated the induction of spermatogenesis in patients with non-obstructive azoosperm...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2005-915619
更新日期:2006-03-01 00:00:00
abstract::Urinary tract infections (UTI) are amongst the most frequent bacterial infections and therefore responsible for a great amount of antibiotic administration. UTI may present as benign, uncomplicated cystitis or severe, life-threatening urosepsis. Due to the heterogeneity of UTI the European Section of Infections in Uro...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1368176
更新日期:2014-03-01 00:00:00
abstract::Unenhanced computed tomography (CT) has a sensitivity of 97.7 to 100 % for the detection of urolithiasis. Using a modified examination protocol, the radiation exposure of a CT examination can be reduced to the level of a single conventional radiographic view of the abdomen (ultra-low-dose CT), assuming the examination...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-2004-830031
更新日期:2004-08-01 00:00:00
abstract:INTRODUCTION:Ovarian metastases of renal cell cancer (RCC) are extremely rare with less than 20 cases reported to date. These metastases occur in the majority of cases metachronous (i. e. prior to or after identification of the primary tumour) or--such as in our case--synchronous. CASE REPORT:A 42-year-old women was d...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2006-932159
更新日期:2007-01-01 00:00:00
abstract::The precise identification and detection of bladder tumours is a prerequisite for complete transurethral resection and, thus, the reduction of recurrence. White-light cystoscopy remains the gold standard and has been further improved by the introduction of digital HD techniques. New digital techniques such as narrow-b...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0731-0008
更新日期:2019-02-01 00:00:00
abstract::Inguinal bladder hernia accounts for only 1 - 4 % of all inguinal hernias. It may be difficult to diagnose due to the atypical symptoms. In most cases, the diagnosis is only made intraoperatively. However, a preoperative diagnosis is important to avoid possible iatrogenic complications. We report a case series of five...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/a-1190-3186
更新日期:2020-06-18 00:00:00
abstract:PURPOSE:Gap junctions are intercellular contacts important for the synchronization of muscle cell activity through electrical coupling. Since the role of gap junctions for the function of smooth bladder muscle is still a matter of debate, we investigated the occurrence of gap junctions and the gap junctional protein co...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-42001
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to integrate and validate an additional post-treatment module including improvement and satisfaction scales to the validated German pelvic floor questionnaire. METHODS:The questionnaire contained the domains bladder, bowel prolapse, and sexual symptoms. It was completed by 55 patie...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0031-1271544
更新日期:2011-09-01 00:00:00
abstract::Between 15 and 20 % of patients diagnosed with renal cell carcinoma suffer from metastatic disease by the time of diagnosis. In addition to systemic therapy, there are various surgical strategies to treat the primary tumour, e. g. cytoreductive nephrectomy (CN) or palliative nephrectomy (PN). In the immunotherapy era,...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0658-0832
更新日期:2018-09-01 00:00:00
abstract::In this narrative review, we give an overview of contemporary conservative treatment concepts for urinary incontinence in female patients. Hereby, we focus on pure stress urinary incontinence, urge incontinence and mixed urinary incontinence. We emphasise the value of rationally used diagnostic methods to be able to d...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0043-121483
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:Throughout the past years, several studies have shown that fluorescence cystoscopy with ALA (5-aminolevulinic acid) improves the detection rate of superficial bladder tumors by approximately 20 % compared to standard white light cystoscopy. These results suggest a reduced rate of residual/recurrent tumors with ...
journal_title:Aktuelle Urologie
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1055/s-2004-818544
更新日期:2004-11-01 00:00:00
abstract::The scrotal leiomyoma is a rare benign tumour, deriving from the smooth muscle. This tumour entity constitutes a differential diagnosis to malignant testicular tumours. Up to now, only 8 cases have been reported in the literature. We report on a 63-year-old European patient, presenting in our clinic for further treatm...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1385898
更新日期:2014-07-01 00:00:00
abstract::The prevalence of kidney stones is increasing worldwide. Asymptomatic non-obstructing kidney stones are increasingly detected as an incidental finding on radiologic imaging, which has been performed more frequently over the last decades. Beside the current interventional treatment modalities such as extracorporeal sho...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0035-1559651
更新日期:2015-09-01 00:00:00
abstract::The outpatient forensic aftercare department of the Charité Berlin treated 32 paraphilic sex offenders with GnRH analogues within the past 5 years. Out of those patients, three men suffered from urolithiasis and were in need of treatment. All 3 patients had previously developed osteopenia/osteoporosis while on antiand...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0042-112999
更新日期:2016-12-01 00:00:00
abstract::At present medical castration employing luteinising hormone releasing hormone (LHRH) agonists is the standard of care for patients with advanced prostate cancer. LHRH agonists suppress the synthesis of testosterone to a castration level. In contrast to surgical castration, medical castration is reversible. However LHR...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0028-1098882
更新日期:2009-05-01 00:00:00
abstract::Although ureteroarterial fistulas are rare, they result in a high mortality because of the massive urogenital haemorrhage. The diagnosis is often difficult even when invasive measures are applied. Including the ureteroarterial fistula in the diagnostic process in cases of macrohaematuria with a positive medical histor...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-0034-1376953
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Germ cell differentiation, DNA synthesis, and apoptosis can be evaluated quantitatively. On the other hand, an interstitial lesion is difficult to examine. We have focused on the quantitative analysis of testicular interstitial fibrosis after vasectomy. MATERIALS AND METHODS:Forty testicular biopsy specimens f...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2003-41612
更新日期:2003-07-01 00:00:00
abstract::The urethral syndrome with urethral pain and bladder voiding disorders is a diagnosis of exclusion. Possible aetiologies are diverse and include organic, functional and inflammatory pathologies of the urethra. Infections, inflammation of the paraurethral glands, spasms of the sphincter muscle and/or of the pelvic floo...
journal_title:Aktuelle Urologie
pub_type: 评论,杂志文章
doi:10.1055/s-0042-106662
更新日期:2016-08-01 00:00:00
abstract::Numerous substances are available for the treatment of metastatic renal cell carcinoma (mRCC). Therefore, medical treatment of patients with mRCC has become a very complex subject. This review summarises clinical studies and typical side-effects of currently available agents that have been approved in Germany. The aut...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/a-0972-0788
更新日期:2019-12-01 00:00:00
abstract::Leiomyomas are benign neoplasms arising from smooth muscle cells. We describe the case of a 17-year-old boy admitted with progressive severe obstructive voiding symptoms. Retrograde urethrography showed a bulbous urethral stricture which was resected with primary urethral anastomosis. Histopathological examination con...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2007-993038
更新日期:2008-03-01 00:00:00
abstract::Patients with metastatic renal cell carcinoma have a life-limiting prognosis. Therefore, the aim of therapy is normally palliative care. Nevertheless, substantial achievements have been made in the past years. Cytokines as long-term standard therapy have been more and more replaced by new targeted therapies. Sunitinib...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1363228
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Acute epididymitis is an inflammation of the epididymis. It mostly occurs unilaterally and may spread to the testis ('epididymo-orchitis') if untreated. Increasing technological advances allow for an even more detailed examination of concurrent symptoms such as ejaculate changes and the whole spectrum of pat...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0042-104803
更新日期:2016-05-01 00:00:00
abstract::In recent years, PSMA-targeting PET tracers such as 68Ga-PSMA-11 have shown promising results, thus contributing to a better management of prostate cancer patients. At the present time, 68Ga-PSMA-11 is most frequently used for diagnostic evaluation in the setting of biochemical recurrence of prostate cancer. In this c...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0043-100269
更新日期:2017-04-01 00:00:00
abstract::Faced with the dilemma of choosing between the extremes of standard whole gland therapy and active surveillance, those affected by prostate cancer have recently been on the lookout for less invasive alternatives. Particularly the question of whether it would be possible in low risk cancer to treat only the tumour itse...
journal_title:Aktuelle Urologie
pub_type: 杂志文章,评审
doi:10.1055/s-0034-1396803
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Hydrocephalus as a complication of tuberculous orchiepididymitis is extremely rare. In this reported case, hydrocephalus was the consequence of a disseminated tuberculous process. CASE REPORT:A 28-year-old man was treated for a left-sided orchiepididymitis. He developed the signs of increased intracranial...
journal_title:Aktuelle Urologie
pub_type: 杂志文章
doi:10.1055/s-2004-830255
更新日期:2006-01-01 00:00:00