The significance of myocardial ischaemia and verapamil treatment on the prevalence of supraventricular tachyarrhythmias in patients recovering from acute myocardial infarction. Danish Study Group on Verapamil in Myocardial Infarction.

Abstract:

:Twenty-four hour Holter monitoring and symptom-limited exercise testing were carried out prior to discharge in 157 patients recovering from acute myocardial infarction. Supraventricular arrhythmias (SVT) during Holter monitoring were recorded in 15%, and ST segment depression during exercise in 27%. No association between exercise-provoked ischaemia and SVT was found in the late hospital phase of myocardial infarction. After the tests, patients were double-blindly randomized to treatment with verapamil 120 mg t.i.d. or placebo. One month after randomization 24 h Holter monitoring was repeated in 125 patients (verapamil = 63, placebo = 62). At one month a significantly increased incidence of SVT was found in the placebo group (25%) compared to the verapamil-treated patients (9%) (P = 0.04). The increased prevalence in the placebo group was mainly due to an increased incidence of SVT in patients with exercise-induced ischaemia (P = 0.03). This increment was blurred in the verapamil group. In conclusion, the prevalence of SVT increases during the first month after myocardial infarction. The increase is most pronounced in patients with residual myocardial ischaemia and seemed to be prevented by treatment with verapamil.

journal_name

Eur Heart J

journal_title

European heart journal

authors

Jespersen CM,Vaage-Nilsen M,Hansen JF

doi

10.1093/oxfordjournals.eurheartj.a060078

subject

Has Abstract

pub_date

1992-10-01 00:00:00

pages

1427-30

issue

10

eissn

0195-668X

issn

1522-9645

journal_volume

13

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    pub_type: 杂志文章,多中心研究,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1990-11-01 00:00:00

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    pub_type: 杂志文章,评审

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验,评审

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    authors: Herrman JP,Simon R,Umans VA,Peerboom PF,Keane D,Rijnierse JJ,Bach D,Kobi P,Kerry R,Close P

    更新日期:1995-11-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2004-07-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a061637

    authors: von Essen R,Hinsen R,Louis R,Merx W,Silny J,Rau G,Effert S

    更新日期:1984-03-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1988-11-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章,评审

    doi:

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    pub_type: 杂志文章

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    更新日期:2001-09-01 00:00:00

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    pub_type: 新闻

    doi:

    authors: Shurlock B

    更新日期:2014-04-01 00:00:00

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    pub_type: 杂志文章,meta分析,评审

    doi:10.1093/eurheartj/ehx437

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    更新日期:2017-11-07 00:00:00

  • Spinal electrical stimulation for intractable angina--long-term clinical outcome and safety.

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    pub_type: 杂志文章

    doi:10.1093/oxfordjournals.eurheartj.a060589

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    更新日期:1994-06-01 00:00:00

  • A multicentre, double-blind randomized crossover comparative study on the efficacy and safety of dofetilide vs sotalol in patients with inducible sustained ventricular tachycardia and ischaemic heart disease.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    authors: Schoemaker RG,Smits JF

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    doi:10.1093/eurheartj/ehy310

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    pub_type: 杂志文章,评审

    doi:10.1093/eurheartj/ehm634

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    更新日期:2008-03-01 00:00:00