Left ventricular thrombosis and arterial embolism after thrombolysis in acute anterior myocardial infarction: predictors and effects of adjunctive antithrombotic therapy.

abstract：Aims:To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). Methods and results:SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding...

journal_title：European heart journal

authors： Pieske B,Maggioni AP,Lam CSP,Pieske-Kraigher E,Filippatos G,Butler J,Ponikowski P,Shah SJ,Solomon SD,Scalise AV,Mueller K,Roessig L,Gheorghiade M

更新日期：2017-04-14 00:00:00

abstract：AIMS:Thrombin plays a key role in the clinical syndrome of unstable angina. We investigated the safety and efficacy of five dose levels of efegatran sulphate, a direct thrombin inhibitor, compared to heparin in patients with unstable angina. METHODS:Four hundred and thirty-two patients with unstable angina were enroll...

journal_title：European heart journal

authors： Klootwijk P,Lenderink T,Meij S,Boersma H,Melkert R,Umans VA,Stibbe J,Müller EJ,Poortermans KJ,Deckers JW,Simoons ML

更新日期：1999-08-01 00:00:00

abstract：:The efficacy and safety of a single infusion of cibenzoline, a class I antiarrhythmic drug, were assessed in 86 patients presenting with a supraventricular tachyarrhythmia following heart surgery in a placebo-controlled double-blind parallel study. Cibenzoline was effective in 13 patients (30%) vs three patients (6.9%...

journal_title：European heart journal

authors： Ollitrault J,Quilliet L,Scheck F,Lelong B,Richard A,Jarry G,Guize L

更新日期：1994-09-01 00:00:00

abstract：:The efficacy of sustained-release diltiazem (diltiazem-SR) 120 mg b.i.d. was compared with metoprolol 100 mg b.i.d. in 12 patients with stable angina. Following a 1-week placebo period, patients received diltiazem-SR or metoprolol in two 3-week treatment periods, in a randomized double-blind crossover design. Total ex...

journal_title：European heart journal

authors： Posma JL,van Dijk RB,Lie KI

更新日期：1989-10-01 00:00:00

abstract：:Some studies provide a link between the width of QRS complexes and late potentials occurring at the end of the QRS complex in signal-averaged recordings. The purpose of this study was to compare three methods of QRS duration measurement: the conventional 12 lead ECG, the Frank vectorcardiogram (VCG) and the signal-ave...

journal_title：European heart journal

authors： Brembilla-Perrot B

更新日期：1994-01-01 00:00:00

abstract：AIM:It has recently been suggested that exercise testing may be more valuable prognostically than it is diagnostically in apparently healthy subjects. We wanted to compare the accuracy of CHD risk assessment based on classical risk factors with an assessment also based on multiple exercise test parameters. METHODS AND...

journal_title：European heart journal

authors： Erikssen G,Bodegard J,Bjørnholt JV,Liestøl K,Thelle DS,Erikssen J

更新日期：2004-06-01 00:00:00

abstract：:In the Danish Verapamil Infarction Trial II (DAVIT II) intervention with verapamil significantly decreased the first major event rate (i.e. reinfarction or death) in patients recovering from acute myocardial infarction. As calcium channel antagonists might have a detrimental effect in patients with heart failure, the ...

journal_title：European heart journal

authors： Jespersen CM

更新日期：1993-04-01 00:00:00

abstract：:Oxygen consumption was measured during 30 min of work in 16 patients, after a myocardial infarction (anterior or posterior), and compared with 16 normal subjects, of the same age, involved in the same activities, in a steel factory. The VO2 at work of the patients was a little lower than in normals. The mean heart rat...

journal_title：European heart journal

authors： Denolin H,Riviere A

更新日期：1988-11-01 00:00:00

abstract：AIMS:Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular (CV) risk estimation. Its application as a routine tool for clinical patient evaluation has been hampered by the absence of reference values. The aim of the present study is t...

journal_title：European heart journal

authors： Reference Values for Arterial Stiffness' Collaboration.

更新日期：2010-10-01 00:00:00

abstract：Aims:Inhalation of nitric oxide (iNO) during myocardial ischaemia and after reperfusion confers cardioprotection in preclinical studies via enhanced cyclic guanosine monophosphate (cGMP) signalling. We tested whether iNO reduces reperfusion injury in patients with ST-elevation myocardial infarction (STEMI; NCT01398384)...

journal_title：European heart journal

authors： Janssens SP,Bogaert J,Zalewski J,Toth A,Adriaenssens T,Belmans A,Bennett J,Claus P,Desmet W,Dubois C,Goetschalckx K,Sinnaeve P,Vandenberghe K,Vermeersch P,Lux A,Szelid Z,Durak M,Lech P,Zmudka K,Pokreisz P,Vranckx

更新日期：2018-08-01 00:00:00

abstract：:The benefits of exercise are irrefutable. Individuals engaging in regular exercise have a favourable cardiovascular risk profile for coronary artery disease and reduce their risk of myocardial infarction by 50%. Exercise promotes longevity of life, reduces the risk of some malignancies, retards the onset of dementia, ...

journal_title：European heart journal

authors： Sharma S,Merghani A,Mont L

更新日期：2015-06-14 00:00:00

abstract：:MitraClip therapy consists of percutaneous edge-to-edge coaptation of the mitral leaflets that is analogous to the surgical Alfieri technique. The safety profile of the MitraClip device is favourable, and survival outcomes in high-surgical-risk patients are superior to historical controls. However, questions remain re...

journal_title：European heart journal

authors： Rogers JH,Franzen O

更新日期：2011-10-01 00:00:00

abstract：AIMS:Patients with chronic heart failure (CHF) exhibit detrimental changes in skeletal muscle that contribute to their impaired physical performance. This study investigates the possibility of counteracting these changes by chronic low-frequency electrical stimulation (CLFS) of left and right thigh muscles. METHODS AN...

journal_title：European heart journal

authors： Nuhr MJ,Pette D,Berger R,Quittan M,Crevenna R,Huelsman M,Wiesinger GF,Moser P,Fialka-Moser V,Pacher R

更新日期：2004-01-01 00:00:00

abstract：:Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs assessing serious outcomes in cardiovascular disease have grown, with 'megatrials' becoming more common with the realization that wrong conclusions resulted from random error in inadequately sized trials. Simple design a...

journal_title：European heart journal

authors： Hilbrich L,Sleight P

更新日期：2006-09-01 00:00:00

abstract：AIMS:To compare the precursor of atrial and brain natriuretic peptide (N-ANP, N-BNP), brain natriuretic peptide (BNP), big endothelin-1, the 6-min walk test and the Minnesota Living with Heart Failure Questionnaire (LHFQ) with regard to short-term outcome in an ambulatory heart failure population. METHODS AND RESULTS:...

journal_title：European heart journal

authors： Hülsmann M,Berger R,Sturm B,Bojic A,Woloszczuk W,Bergler-Klein J,Pacher R

更新日期：2002-06-01 00:00:00

abstract：:Orally active angiotensin converting enzyme (ACE) inhibitors have been successfully used in the treatment of congestive heart failure and hypertension. However, adverse skin reactions, such as angioneurotic oedema have been reported following such medication. Furthermore, these drugs have been associated with a persis...

journal_title：European heart journal

authors： Andersson RG,Persson K

更新日期：1994-08-01 00:00:00

abstract：:To evaluate gender-related differences in left ventricular (LV) structure and function in aortic stenosis, LV biplane cineangiography, micromanometry and endomyocardial biopsies were carried out in 56 patients with aortic stenosis and normal coronary arteries. Patients were divided into males (M: n = 35), and females ...

journal_title：European heart journal

authors： Villari B,Campbell SE,Schneider J,Vassalli G,Chiariello M,Hess OM

更新日期：1995-10-01 00:00:00

abstract：:Clinical management of refractory heart failure remains challenging, with a high rate of rehospitalizations despite advances in medical and device therapy. Care can be provided in person, via telehomecare (by telephone), or telemonitoring, which involves wireless technology for remote follow-up. Telemonitoring wireles...

journal_title：European heart journal

authors： Hasan A,Paul V

更新日期：2011-06-01 00:00:00

abstract：:Supraventricular tachycardia is due to altered automaticity, triggered activity or most commonly, reentry. Atrial flutter is most frequently due to reentry with counterclockwise activation in the right atrium with the left atrium acting as a bystander. The small wavefronts demonstrated during atrial fibrillation are l...

journal_title：European heart journal

authors： Shakespeare CF,Anderson M,Camm AJ

更新日期：1993-09-01 00:00:00

abstract：:This case report describes the delayed improvement of left ventricular function by recanalization of an occluded coronary artery in a patient with intractable heart failure and three-vessel disease. The left anterior descending coronary artery was occluded distal to the first septal branch, the dominant right coronary...

journal_title：European heart journal

authors： Klein HH,Neuhaus KL

更新日期：1990-03-01 00:00:00

abstract：AIMS:Aldosterone plays a crucial role in cardiovascular disease. 'Systemic' inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important cardiovascular risk factor, is an inflammatory disease associated with increased plasma aldosterone...

journal_title：European heart journal

authors： Schäfer N,Lohmann C,Winnik S,van Tits LJ,Miranda MX,Vergopoulos A,Ruschitzka F,Nussberger J,Berger S,Lüscher TF,Verrey F,Matter CM

更新日期：2013-12-01 00:00:00

abstract：AIMS:Combined quantitative coronary angiography and intracoronary Doppler flow velocity measurements were performed to study the underlying haemodynamic mechanisms leading to myocardial ischaemia in patients with myocardial bridging in the absence of coronary artery disease. METHODS AND RESULTS:In 42 symptomatic patie...

journal_title：European heart journal

authors： Schwarz ER,Klues HG,vom Dahl J,Klein I,Krebs W,Hanrath P

更新日期：1997-03-01 00:00:00

abstract：AIMS:We investigated the role of asymmetric dimethylarginine (ADMA) for clinical outcome of patients with unstable angina. METHODS AND RESULTS:Forty-five patients with stable angina, 36 patients with unstable angina, and 40 healthy controls were included in this study. Coronary artery disease (CAD) patients were prosp...

journal_title：European heart journal

authors： Krempl TK,Maas R,Sydow K,Meinertz T,Böger RH,Kähler J

更新日期：2005-09-01 00:00:00

abstract：AIMS:To investigate whether the benefit of thrombolytic therapy was sustained beyond the first decade. We report the 10-14 year outcome of 533 patients who were randomized to treatment with intracoronary streptokinase or to conventional therapy during the years 1980-1985. METHODS AND RESULTS:Details of survival and ca...

journal_title：European heart journal

authors： Maas AC,van Domburg RT,Deckers JW,Vermeer F,Remme WJ,Kamp O,Manger Cats V,Simoons ML

更新日期：1999-06-01 00:00:00

abstract：AIMS:Migration, urbanization, and change in socio-economic factors have potentially profound effects on heart disease in low-to-middle income countries. METHODS AND RESULTS:Chris Hani Baragwanath Hospital in Soweto, South Africa, provides health care to >1 million Africans. We systematically captured data from all de ...

journal_title：European heart journal

authors： Stewart S,Carrington M,Pretorius S,Methusi P,Sliwa K

更新日期：2011-02-01 00:00:00

abstract：AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

journal_title：European heart journal

authors： Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

更新日期：2014-04-01 00:00:00

abstract：AIMS:To test the hypothesis that increasing age in patients presenting with high-risk non-ST-segment elevation acute coronary syndromes (NSTE-ACS) does not adversely influence the benefit of an early invasive strategy on major adverse events at 6 months. METHODS AND RESULTS:We report clinical outcomes in young (<70), ...

journal_title：European heart journal

authors： Devlin G,Gore JM,Elliott J,Wijesinghe N,Eagle KA,Avezum A,Huang W,Brieger D,GRACE Investigators.

更新日期：2008-05-01 00:00:00

abstract：AIM:Few epidemiological data are available describing the sudden death of persons in their prime. This study aims to elucidate when and how sudden death occurs among employees. METHODS:A total of 196775 employees from 10 workplaces in Central Japan were surveyed for non-traumatic sudden death during 1989-1995. Demogra...

journal_title：European heart journal

authors： Kawamura T,Kondo H,Hirai M,Wakai K,Tamakoshi A,Terazawa T,Osugi S,Ohno M,Okamoto N,Tsuchida T,Ohno Y,Toyama J

更新日期：1999-03-01 00:00:00

abstract：:Coronary revascularization procedures by means of percutaneous coronary interventions or coronary artery bypass graft surgeries are performed worldwide daily for the symptomatic treatment of patients with myocardial ischaemia. Nevertheless, angina remains a significant clinical problem. Management of angina recurring ...

journal_title：European heart journal

authors： Abbate A,Biondi-Zoccai GG,Agostoni P,Lipinski MJ,Vetrovec GW

更新日期：2007-05-01 00:00:00

abstract：AIM:Unstable coronary artery disease (CAD) is a multifactorial disease involving both thrombotic and inflammatory processes. We have assessed the time-course and the influence of thrombin inhibitors on changes in fibrinogen and C-reactive protein levels, and their relation to myocardial ischaemia in unstable CAD. METH...

journal_title：European heart journal

authors： Oldgren J,Wallentin L,Grip L,Linder R,Nørgaard BL,Siegbahn A

更新日期：2003-01-01 00:00:00