Response to activated protein C decreases throughout pregnancy.

Abstract:

BACKGROUND:The possibility that changes in activated protein C anticoagulant activity may contribute to the hemostatic changes associated with pregnancy has been previously investigated, but the results of the studies are still controversial. METHODS:Nine hundred and sixty-one healthy nonpregnant and 711 normal pregnant women who were noncarriers of factor V Leiden at different weeks' gestation were included in a cross-sectional trial. Moreover, the APC ratio was repeatedly measured in 45 women throughout pregnancy. The activated protein C ratio was tested using the modified activated partial thromboplastin time-based assay. RESULTS:A significantly lower APC ratio was observed at 20-28 and 32-38 (p = 0.0001) weeks' gestation compared with nonpregnant values. The decrease in the APC ratio throughout pregnancy showed a significant trend (p = 0.014). In none of the subjects did the APC ratio reach the cut-off values for APC resistance. CONCLUSIONS:Our data confirm a reduction in the APC ratio throughout pregnancy. In our series, an APC ratio of less than 2.0 according to the cut-off point of our laboratory).

authors

Benedetto C,Marozio L,Tavella AM,Maulà V,Carmignani D,Curti A

doi

10.1034/j.1600-0412.2002.811106.x

subject

Has Abstract

pub_date

2002-11-01 00:00:00

pages

1028-32

issue

11

eissn

0001-6349

issn

1600-0412

pii

aog811106

journal_volume

81

pub_type

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