Difficulties in the antenatal assessment of neonatal alloimmune thrombocytopenia.

Abstract:

:In this paper we present a patient with an initially questionable history of neonatal alloimmune thrombocytopenia (NAT) due to materno-fetal HPA-1a (PLA1) incompatibility. No circulating antibodies were detectable in untreated maternal serum, but an adsorption/elution technique enabled the demonstration of the platelet-specific anti-HPA-1a (anti-PLA1) in maternal serum. Cordocentesis at 35 weeks of gestation revealed a fetal platelet count of 18 x 10(9)/l. Intrauterine platelet transfusion with HPA-1a (PLA1)-negative donor platelets was performed prior to cesarean section.

authors

Marzusch K,Fischer J,Dietl J,Wiest E,Völklein K,Schnaidt M

doi

10.3109/00016349309058169

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

583-5

issue

7

eissn

0001-6349

issn

1600-0412

journal_volume

72

pub_type

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