Abstract:
:Epigenetic modification controls gene activity without changes in the DNA sequence. The genome undergoes several phases of epigenetic programming during gametogenesis and early embryo development, coinciding with assisted reproductive technologies (ART) treatments. Imprinting disorders have been associated with ART techniques, but disentangling the influence of the ART procedures per se from the effect of the reproductive disease of the parents is a challenge. Epidemiological human studies have shown altered birthweight profiles in ART compared with spontaneously conceived singletons. Conception with cryopreserved/thawed embryos results in a higher risk of large-for-gestational-age babies, which may be due to epigenetic modification. Further animal studies have shown altered gene expression profiles in offspring conceived by ART related to altered glucose metabolism. It is controversial whether human adolescents conceived by ART have altered lipid and glucose profiles and thereby a higher long-term risk of cardiovascular disease and diabetes. This commentary describes the basic concepts of epigenetics and gives a short overview of the existing literature on the association between imprinting disorders, epigenetic modification and ART.
journal_name
Acta Obstet Gynecol Scandjournal_title
Acta obstetricia et gynecologica Scandinavicaauthors
Pinborg A,Loft A,Romundstad LB,Wennerholm UB,Söderström-Anttila V,Bergh C,Aittomäki Kdoi
10.1111/aogs.12799subject
Has Abstractpub_date
2016-01-01 00:00:00pages
10-5issue
1eissn
0001-6349issn
1600-0412journal_volume
95pub_type
杂志文章,评审abstract:OBJECTIVE:To compare maternal and neonatal outcomes of term large for gestational age (LGA) pregnancies and adequate for gestational age (AGA) pregnancies. DESIGN:Retrospective analysis. SETTING:Large university research medical center. POPULATION:All term singleton LGA (birthweight ≥ 90th percentile) and AGA pregna...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.1600-0412.2012.01412.x
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:To compare neonatal and maternal outcomes for breech first twins according to whether vaginal or cesarean delivery was planned and to verify that in appropriate selected cases, attempted vaginal delivery is a reasonable choice. METHODS:A retrospective study of all twin pregnancies with the first twin in bre...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,多中心研究
doi:10.1080/00016340601089594
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To describe developments in reproductive long-term prognosis in women with a first ectopic pregnancy as compared with two control cohorts. DESIGN:Controlled cohort study. SETTING:Data were collected from four national Danish registries. POPULATION:All Danish women of reproductive age (15-49 years) through ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.12377
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The effect of physical training on bone mineral density (BMD) in women with endometriosis treated with gonadotropin-releasing hormone (GnRH) analogs was studied. METHODS:Nineteen Caucasian premenopausal women aged 23-38 years were included in the study. The subjects were all treated with 21.6 mg goserelin d...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.0001-6349.2005.00558.x
更新日期:2005-04-01 00:00:00
abstract::A case of benign Müllerian tumor of the ovary in a 53-year old woman is reported. The stromal element consisted of rhabdomyoblasts which clearly indicate that this tumor belongs to the Müllerian family. She remains free of disease 12 months following an abdominal hysterectomy and bilateral salpingo-oophorectomy. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349209021101
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Emergent cervical cerclage is often unsuccessful in patients with severely protruding fetal membranes for the following reasons: (1) difficulty in pushing the bulging membranes into the cervix; (2) risk of premature rupture of membranes during the operative procedures; and (3) displacement of the cerclage ta...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Aortic stenosis (AS) is an uncommon complication during pregnancy, but when it occurs it results in significant maternal and fetal morbidity and mortality. We present a gravida with severe AS in which aortic valve replacement was performed in the 3rd trimester of her pregnancy. She had severe AS with mild aortic regur...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349009028713
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:Massive hemorrhage due to placenta previa with placenta accreta spectrum is associated with high maternal mortality and morbidity. Therefore, accurate prediction of placenta previa with placenta accreta spectrum is essential; magnetic resonance imaging (MRI) is a useful tool for this purpose. This study in...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13937
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The influence of the restrictive use of episiotomy at perineal tears judged to be imminent on the urethral pressure profile, analmanometric, and other pelvic floor findings is unknown. METHODS:Follow-up study of a randomized controlled trial with two perineal management policies includes the use of episioto...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.0001-6349.2005.00585.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Open multidisciplinary centers were operated in the mid 1990s for victims of sexual assaults in Oslo and Reykjavik. However, in Copenhagen and Helsinki forensic medical examination was only available to victims who reported directly to the police. One of the main aims of this study was to compare the effect ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/j.0001-6349.2005.00641.x
更新日期:2005-02-01 00:00:00
abstract::We studied vaginal erotic sensitivity by vaginal sexological examinations as part of the evaluation and treatment process of couples complaining of female coital anorgasmia but readily orgasmic at female self--or partner-performed external genital stimulation. The existence on the anterior vaginal wall of an anatomica...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609161498
更新日期:1986-01-01 00:00:00
abstract::Tumors of the fallopian tube are extremely rare. A case of a papilloma occluding the right fallopian tube of a woman with primary sterility is reported. ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348809004177
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To analyze human papillomavirus (HPV) DNA in umbilical cord blood and in placenta, including its cellular localization. DESIGN:Longitudinal prospective study. SETTING:Maternity Unit of Turku University Hospital, and MediCity, University of Turku. SAMPLES:Placental and cord blood samples obtained at deliver...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340802468308
更新日期:2008-01-01 00:00:00
abstract::A prospective study has been performed on the use of psychopharmaca during 6 376 pregnancies and its correlation to certain socio-medical variables and pregnancy outcome. An association between drug use and later miscarriage or legal abortion was demonstrated and is conceivably due to an increased use of such drugs in...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016347609156779
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:Early mother-infant relationships in preterm populations were evaluated in the context of a systematic review of the literature. DESIGN AND SETTING:A systematic search of three electronic databases (PsychINFO, PubMed and Cochrane Library) was undertaken. Three studies of maternal attachment, 18 studies of mo...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1600-0412.2011.01304.x
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:A major goal of Finnish family planning policy since the 1970s has been to minimize unintended pregnancies by providing equal contraception and abortion services throughout the country. This report looks at how this policy has succeeded among teenagers. METHODS:The data on childbirths, induced abortions and...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349609054668
更新日期:1996-07-01 00:00:00
abstract::Normal pregnancy leads to a state of chronically increased intra-abdominal pressure. Obstetric and non-obstetric conditions may increase intra-abdominal pressure further, causing intra-abdominal hypertension and abdominal compartment syndrome, which leads to maternal organ dysfunction and a compromised fetal state. Li...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,评审
doi:10.1111/aogs.13638
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:The advantages of non-closure of the visceral and parietal peritoneum at lower segment cesarean section seems to be evident but in the reports published so far, the number of patients studied has been relatively small and the follow-up periods short. It is obviously of value to reconfirm such important obser...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1034/j.1600-0412.1998.770123.x
更新日期:1998-01-01 00:00:00
abstract:INTRODUCTION:There is little evidence to guide the timing of delivery of women with early-onset severe preeclampsia. We hypothesize that immediate delivery is not inferior for neonatal outcome but reduces maternal complications compared with temporizing management. MATERIAL AND METHODS:This Dutch multicenter open-labe...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13976
更新日期:2021-01-01 00:00:00
abstract::A prospective study of the clinical value of the symphysis-fundus (SF) distance was performed on 528 women, all at risk for developing intrauterine growth retardation (IUGR). Four different types of SF curves were observed and denoted as normal, static, catch-up and low. A normal or static SF curve predicted a normal ...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348409155527
更新日期:1984-01-01 00:00:00
abstract::One hundred and five consecutive pregnancies in 79 women affected by hyperthyroidism were observed during an 8-year period. All had received treatment either with carbimazole alone (Group I) or with the combination of carbimazole and propranolol (Group II). There were 72 pregnancies in Group I, 33 in Group II. Seventy...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016349109007160
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:We conducted a prospective health service evaluation to assess the feasibility and acceptability of routinely offering insertion of intrauterine contraception at cesarean section in a maternity setting in the UK. MATERIAL AND METHODS:One month before scheduled cesarean section, women were sent information...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1111/aogs.13178
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:To study the effect of single-dose prophylactic Augmentin on patients undergoing cesarean section. METHODS AND MATERIAL:Three hundred and twenty women undergoing cesarean section were randomized into two groups in a prospective, double-blind, placebo-controlled study. One hundred and sixty women were alloca...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/00016349709024581
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:This study was carried out to evaluate the efficacy of HPV-DNA (Human Papilloma Virus) testing as a triage strategy for persistent borderline and mild cytological abnormalities. METHODS:A prospective cross-sectional study involving 321 women registered between January and December 2001 with two smears showi...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1034/j.1600-0412.2003.00155.x
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Possible effects of termination of pregnancy (TOP) on mental health are a matter of debate. MATERIAL AND METHODS:We assessed anxiety and quality of life during a one-year follow up after first-trimester TOP using the State-Trait Anxiety Inventory (STAI) Scale and EuroQoL Quality of Life Questionnaire (EQ-...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章,随机对照试验
doi:10.1111/aogs.12959
更新日期:2016-10-01 00:00:00
abstract::Four patients with endometrial foam cells are described. In one the endometrium was obtained after parturition. It showed decidua and endometritis, whereas in the second patient, who had received birth control medication in the past, the endometrium was proliferative. In both cases there was a considerable amount of e...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309155791
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The aim of this retrospective study is to verify whether some maternal features are related to pregnancy outcome in cases of emergency mid-trimester cerclage when membranes are protruding through the dilated cervix. METHODS:Between 1988 and 1996 twenty-three pregnant patients with dilated cervix and protrud...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Midwives in Sweden are responsible for taking Papanicolaou (Pap) smears as part of the cervical cancer screening program. The aim of this study was to investigate midwives knowledge, experience and management of the cervical cancer screening program, and their apprehension of women's knowledge about Pap-smea...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.1080/00016340701371272
更新日期:2007-01-01 00:00:00
abstract::Ninety-nine consecutive diabetic pregnancies (101 infants) were monitored with altogether 2672 nonstress tests (NSTs) from about 30 weeks of gestation until parturition. In 96% of the women the last NST was performed within 2 days of delivery. Fifty-nine percent had normal NSTs throughout pregnancy. Only 3.7% of the 2...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348609155178
更新日期:1986-01-01 00:00:00
abstract::Amniotic fluid from 207 women in labor was analysed at the time of artificial rupture of membranes or by amniocentesis. The following organisms were identified in concentrations of more than 1 000/ml: Staphylococcus aureus (1), Propionibacterium (1), E. coli (1), group B Streptococci (3), Lactobacilli (16). The 6 pati...
journal_title:Acta obstetricia et gynecologica Scandinavica
pub_type: 杂志文章
doi:10.3109/00016348309156257
更新日期:1983-01-01 00:00:00